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Gynecologic Cancer Trials

GOG 0238: A Randomized Trial of Pelvic Irradiation with or without Concurrent Weekly Cisplatin in Patients with Pelvic-Only Recurrence of Carcinoma of the Uterine Corpus
Aims: The purpose of this study is to compare a combination of radiation therapy and weekly treatment of the chemotherapy drug cisplatin to the standard treatment for this type of cancer which is radiation therapy alone. This study will also evaluate the side effects of combining radiation therapy and chemotherapy with cisplatin. 
Diagnosis: Recurrent Endometrial Cancer 
Principal Investigator: Mary Tilley Jenkins-Vogel, MD 
IRB Approval Number: EH09-122
Sponsor: Gynecologic Oncology Group (GOG) 
Contact: Interested patients should contact study nurse Tara Flanagan, RN at 847.570.1768
Open to Enrollment: Yes 

UC13-1235: A Randomized Placebo Controlled Phase II Trial of Metformin in Conjunction with Chemotherapy
Aims: The purpose of this study is to see if participants who receive 6 cycles of carboplatin plus either paclitaxel or docetaxel (standard chemotherapy ) plus metformin followed by metformin alone continued after the chemotherapy will have an improved outcome compared to those receiving 6 cycles of carboplatin plus either paclitaxel or docetaxel (standard chemotherapy) plus placebo followed by placebo alone continued after chemotherapy.  
Diagnosis: Ovarian, fallopian tube or primary peritoneal cancer (cancer of the lining of the abdomen) for which you have already undergone surgery
Principal Investigator: Gustavo Rodriguez, MD
IRB Approval Number: EH14-274
Sponsor: University of Chicago
Contact: Interested patients should contact research nurse Michele Britto, RN at 847.570.2109
Open to Enrollment: Yes

Pilot Study of the Impact of Early Palliative Care on Quality of Life in Recurrent Ovarian, Fallopian Tube and Primary Peritoneal Cancer
Aims: The purpose of this study is to see if participants who see Palliative Care physicians at an earlier timepoint have a better quality of life.  
Diagnosis: Ovarian, fallopian tube or primary peritoneal cancer (cancer of the lining of the abdomen) for which you have already had treatment
Principal Investigator: Elena Moore, MD
IRB Approval Number: EH15-193
Sponsor: NorthShore
Contact: Interested patients should contact research nurse Michele Britto, RN at 847.570.2109
Open to Enrollment: Yes

NRG-GY005: A Randomized Phase II/III Study of the Combination of Cediranib and Olaparib compared to Cediranib or Olaparib alone, or Standard of Care Chemotherapy in Women with Recurrent Platinum-Resistant or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (COCOS)
Aims: The purpose of this study is to see if the combination of cediranib and olaparib, or each drug on it's own is as good or better than standard chemotherapy.  
Diagnosis: Ovarian, fallopian tube or primary peritoneal cancer (cancer of the lining of the abdomen) for which you have already had prior treatment
Principal Investigator: Mary Tilley Jenkins-Vogel, MD
IRB Approval Number: EH16-273
Sponsor: NRG Oncology
Contact: Interested patients should contact research nurse Tara Flangan at 847.570.1768 or e-mail tflanagan@northshore.org
Open to Enrollment: Suspended

AGCT-1531: A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
Aims: The purpose of this study is if active surveillance is an acceptable method of monitoring patients wtih germ cell tumors. If the cancer is standard risk, the trial is testing which chemotherapy is better.
Diagnosis: Germ Cell tumors
Principal Investigator: Mary Tilley Jenkins-Vogel, MD
IRB Approval Number: EH17-350
Sponsor: Children's Oncology Group
Contact: Interested patients should contact research nurse Tara Flangan at 847.570.1768 or e-mail tflanagan@northshore.org
Open to Enrollment: Yes

GOG 0264:A Randomized Phase III Trial of Paclitaxel and Carboplatin vs. Bleomycin, Etoposide, and Cisplatin for Newly Diagnosed Advanced Stage and Recurrent Chemonaive Sex-Cord Stomal Tumors of the Ovary
Aims: The purpose of the study is to compare the treatment with drugs, paclitaxel and carboplatin work better than treatment with the drugs bleomycin, etoposide and cisplatin, which is the standard of care treatment for this type of cancer.
Diagnosis: Sex-Cord Stromal tumors
Principal Investigator: Mary Tilley Jenkins-Vogel, MD
IRB Approval Number: EH15-271
Sponsor: NRG-GOG
Contact: Interested patients should contact research nurse Tara Flanagan, RN at 847.570.1768 or tflanagan@northshore.org
Open to Enrollment: Yes 

NRG-GY009: A Randomized Phase II/III Study of Pegylated Liposomal Doxorubicin and CTEP Supplied Atezolizumab Versus Pegylated Liposomal Doxorubicin/Bevacizumab and CTEP-Supplied Atezolizumab Versus Peglyated Liposomal Doxorubicin/Bevaciuzmab in Platinum Resistant Ovarian Cancer
Aims: The purpose of this study is to see if the addition of atezolizumab to standard therapy is better than standard therapy alone.
Diagnosis: Ovarian, fallopian tube or primary peritoneal cancer (cancer of the lining of the abdomen)
Principal Investigator: Mary Tilley Jenkins-Vogel, MD
IRB Approval Number: EH18-322
Sponsor: NRG Oncology
Contact: Interested patients should contact research nurse Tara Flangan at 847.570.1768 or e-mail tflanagan@northshore.org
Open to Enrollment: Open