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Maternal-Fetal Medicine Trials

Part of the Maternal Fetal Medicine Units (MFMU) Network

Prescription After Cesarean Trial (PACT)
Aims: This study examines two different methods of pain management at home after cesarean delivery. Researchers are comparing an individualized opioid prescription with shared decision making to a fixed opioid prescription.
Eligibility: Cesarean delivery at Evanston Hospital. Enrollment must occur prior to hospital discharge.
Principal Investigator: Beth Plunkett, MD, MPH
IRB Approval Number: EH20-280
Sponsor: The NIH Helping to End Addiction Long-Term Initiative and the Eunice Kennedy Striver National Institute of Child Health and Human Development (NICHD)
Contact: Interested patients can contact Kathy Kearns, RN, by calling 847.570.4253 or emailing kkearns@northshore.org
Open to Enrollment: Yes

Activity in Women at Risk for Early Delivery (AWARE)
Aims: The purpose of this research study is to find out whether reduced physical activity increases time to delivery among women with a short cervix who are at risk of delivering a baby too soon.
Diagnosis: Enrolled in the TOPS study or the PROSPECT study
Principal Investigator: Beth Plunkett, MD, MPH
IRB Approval Number: EH19-279
Sponsor: Eunice Kennedy Striver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (NIH)
Contact: Interested patients can contact Kathy Kearns, RN, by calling 847.570.4253 or emailing kkearns@northshore.org
Open to Enrollment: Yes

A Randomization Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy (SLEEP)
Aims: The purpose of this study is to understand how CPAP for sleep apnea may affect hypertensive disorders of pregnancy and other complication of pregnancy such as gestational diabetes.
Diagnosis: To qualify for this study, women with body mass index of 30 or greater are given a home sleep monitor to wear for one night to see if they have mild to moderate sleep apnea.
Principal Investigator: Beth Plunkett, MD, MPH
IRB Approval Number: EH18-344
Sponsor: Eunice Kennedy Striver National Institute of Child Health and Human Development (NICHD) and National Heart, Lung, and Blood Institute (NHLBI)
Contact: Interested patients can contact Kathy Kearns, RN, by calling 847.570.4253 or emailing kkearns@northshore.org
Open to Enrollment: Yes

Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean Delivery: A Randomized Controlled Trial (TXA)
Aims: This study is being done to find out if a drug called tranexamic acid will prevent severe bleeding (hemorrhage) after a cesarean delivery.
Principal Investigator: Beth Plunkett, MD, MPH
IRB Approval Number: EH18-127
Sponsor: Eunice Kennedy Striver National Institute of Child Health and Human Development (NICHD)
Contact: Interested patients can contact Kathy Kearns, RN, by calling 847.570.4253 or emailing kkearns@northshore.org
Open to Enrollment: No

A Randomized Trial of Pessary in Singleton Pregnancies with a Short Cervix (TOPS)
Aims: The purpose of this research study is to find out whether a pessary lowers the risk of a baby being born too soon to a woman with a short cervix.
Diagnosis: Short cervix diagnosed by transvaginal ultrasound performed by a certified ultrasound technician with NorthShore’s Fetal Diagnostics
Principal Investigator: Beth Plunkett, MD, MPH
IRB Approval Number: EH17-169
Sponsor: Eunice Kennedy Striver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (NIH)
Contact: Interested patients can contact Kathy Kearns, RN, by calling 847.570.4253 or emailing kkearns@northshore.org
Open to Enrollment: Yes

A Randomized Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation with a Short Cervix (PROSPECT)
Aims: The purpose of this research study is to find out whether pessary or vaginal progesterone lowers the risk of babies being born preterm to women who are carrying twins and have a short cervix.
Diagnosis: Short cervix diagnosed by transvaginal ultrasound performed by a certified ultrasound technician with NorthShore’s Fetal Diagnostics
Principal Investigator: Beth Plunkett, MD, MPH
IRB Approval Number: EH16-041
Sponsor: Eunice Kennedy Striver National Institute of Child Health and Human Development (NICHD)
Contact: Interested patients can contact Kathy Kearns, RN, by calling 847.570.4253 or emailing kkearns@northshore.org
Open to Enrollment: Yes