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About the Test

What Does the Genetic Health Screen Test Include?

  • Cancer - A look at 47 genes (23 conditions) to better guide a screening and prevention plan for breast, ovarian, uterine, colon, melanoma, pancreatic, stomach, and prostate cancers.
    • APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, FH, FLCN, GREM1, HOXB13, KIT, MAX, MEN1, MET, MITF, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PDGFRA, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, STK11, TMEM127, TP53, VHL

  • Heart - A look at 54 genes (20 conditions) associated with genetic forms of heart disease, such as inherited high cholesterol, that may be managed differently from heart conditions without a genetic cause.
    • ACTA2, ACTC1, ACTN2, ACVRL1, APOB, BAG3, COL3A1, DES, DSC2, DSG2, DSP, ENG, F2, F5, FBN1, FLNC, GLA, HCN4, JUP, KCNE1, KCNE2, KCNJ2, KCNQ1, LAMP2, LDLR, LMNA, LOX, MYBPC3, MYH11, MYH7, MYL2, MYL3, MYLK, PCSK9, PKP2 PLN, PRKAG2, PRKG1, PROC, RBM20, RYR2, SCN5A, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2, TMEM43, TNNI3, TNNT2, TPM1, TTR

  • Medications - Analysis of genes associated with medication response that impact how the body may process certain medications.*
    • ABCB1, ACE, ADRB2, ANKK1, COMT, CYP1A2, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, DRD2, F2, F5, GRIK4, HTR2A KIF6, MTHFR, NAT2, NUDT15, OPRM1, SLC6A4, SLCO1B1, TPMT, TYMS, UGT1A1, UGT2B15, VKORC1

  • Additional Insights - Analysis of inherited risk for other rare conditions, including Maturity-onset Diabetes of the Young (MODY), Hemochromatosis and Malignant Hyperthermia.
    • CACNA1S, G6PD, GCK, HFE, HNF1A, HNF4, RYR, SERPINA1

What Does the Hereditary Cancer Panel Include?

  • Hereditary Cancer - A look at 36 genes to better guide a screening and prevention plan for breast, ovarian, uterine, colon, renal, pancreatic, prostate cancers and other cancers.  All genes either guideline-driven or have well-established evidence of increased risk for common cancers.  Majority of genes are clinically actionable.
    • APC, ATM, AXIN2, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, DICER1, EPCAM, GREM1, HOXB13, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, RAD51D, SMAD4, SMARCA4, STK11, TSC1, TSC2, TP53, VHL

Your clinical results will be integrated into your NorthShore Electronic Medical Record. This allows your physicians to access your genetic testing results to help design your care plan for now and your future care needs.

*Do not change or stop taking any medicine based on a genetic test report without consulting your healthcare provider. This test is not intended to inform you about your current state of health, including whether or not you should take a medication or how much you should take. This test does not diagnose any health conditions and is not a substitute for visiting your health care provider. Discuss the results of the genetic test with your healthcare provider, including whether the medication label includes information on how to use genetic information to determine dosage. Medicine should always be taken as prescribed by your healthcare provider.