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Home » Research Institute » Investigators » Simon W. Hayward, PhD

Simon William Hayward , PhD

Jean Ruggles Romoser Chair of Cancer Research
Director, Cancer Biology

Clinician Researcher
University of Chicago, Pritzker School of Medicine

Contact Information

 224.364.7672
mailto:shayward@northshore.org

Education

BSc (Hons) - Biochemistry and Biology: Westfield College (University of London) 

MSc - Biomolecular Organisation: Birkbeck College (University of London)

PhD - Cell Biology: Imperial Cancer Research Fund (London)

Research and Academic Interests

  • Prostate Cancer and Benign Prostatic Hyperplasia
  • Tumor Microenvironment
  • Cellular Heterogeneity
  • Effects of Inflammatory Co-morbidities on Prostate Pathobiology
  • Application of Mathematical Modeling to Cancer Biology

Career Summary

Dr. Hayward performed his doctoral work at the Imperial Cancer Research Fund laboratories in London (now Cancer Research UK) where he worked on the development of models of human prostate biology. In 1992 he moved to the University of Californina, San Francisco to perform postdoctoral work under the guidance of Dr. Gerald Cunha. 

Dr. Hayward moved to Vanderbilt University Medical Center in 2001 as an Assistant Professor of Urologic Surgery and Cancer Biology. He was promoted to Associate Professor in 2005 and to Professor in 2011. Dr. Hayward was also the director of the Vanderbilt Benign Urologic Disease Center, which attempts to integrate research in the field of benign urology with the obesity and diabetes research communities on the Vanderbilt campus. He was also a member of the NCI Integrated Cancer Biology Program and the Tumor Microenvironment Network.

Dr. Hayward moved to NorthShore to take up a position as the Director of Cancer Biology in 2015. He brings many years of experience with in vitro and in vivo models of prostate cancer and benign prostatic hyperplasia, including use of tissue recombination models. Work in his laboratory is focused upon understanding the role of the tumor microenvironment, in particular fibroblasts and inflammatory cells, in prostate cancer progression and in dissecting the microenvironmental paracrine signaling pathways leading to benign prostatic hyperplasia and associated symptoms.

His work has been funded by grants from the NCI, NIDDK and the DOD-PCRP, with continuous personal research funding since 1997. He has served on many research panels, study sections and advisoryt boards.  

Honors and Awards

Dr. Hayward is a past-President of the Society for Basic Urologic Research.

 

Scholarly Work

Publications

  1. Hobbs FDR, Dorward J, Hayward G, Yu LM, Saville BR The PRINCIPLE randomised controlled open label platform trial of hydroxychloroquine for treating COVID19 in community based patients at high risk. Scientific reports 2025 Jul 04 PMID: 40615618
  2. Lau JS, Kusumoputro S, Tran AT, Fort V, Lee HC, Pierce LS, Timm JA, Yadav N, Villarta MC, Lebow J Implementation of Family-Based Treatment for Primary Care in a novel healthcare system: description of the adaptation process. Eating disorders 2025 Jul 03 PMID: 40611545
  3. Evans W Enhancing care coordination for neurofibromatosis type 1 in primary care: insights and applications for rare diseases. Journal of community genetics 2025 Jul 03 PMID: 40608210
  4. Narendorf SC Study protocol for a feasibility evaluation of Charge Up!: an adaptation of Critical Time Intervention for young adults moving from homelessness to housing. Pilot and feasibility studies 2025 Jul 02 PMID: 40605122
  5. Font MB, Woolford L Biochemical Reference Intervals of Free-Ranging Koalas (Phascolarctos cinereus) in South Australia. Veterinary clinical pathology 2025 Jul 02 PMID: 40600275
  6. Little JL, Fealy JCM, Kobayashi K, Roth S How note-taking and note-using affects the benefit of interleaving over blocking. Memory & cognition 2025 Jul 01 PMID: 40593279
  7. Albery GF, Sweeny AR, Corripio-Miyar Y, Evans MJ, Hayward A, Pemberton JM, Pilkington JG, Nussey DH Local and global density have distinct and parasite-dependent effects on infection in wild sheep. Parasitology 2025 Jul 01 PMID: 40589062
  8. George J Using population risk prediction for healthcare planning: a qualitative study of healthcare planners' experiences and views. Journal of public health (Oxford, England) 2025 Jul 01 PMID: 40588809
  9. Lessels NS Gastric gastrinoma in a dog: a case report, application of current WHO criteria for prognostication and validation of a local gastrin immunohistochemistry assay. Australian veterinary journal 2025 Jun 30 PMID: 40586294
  10. McCall B Sense of personal agency towards mitigating the threat of antibiotic resistance: a focus group study with parents of children under 5 years old, conducted mid-pandemic. F1000Research 2022 PMID: 40584142
View more results at PubMed.gov