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Simon William Hayward , PhD

Jean Ruggles Romoser Chair of Cancer Research
Director, Cancer Biology

Clinician Researcher
University of Chicago, Pritzker School of Medicine

Contact Information



BSc (Hons) - Biochemistry and Biology: Westfield College (University of London) 

MSc - Biomolecular Organisation: Birkbeck College (University of London)

PhD - Cell Biology: Imperial Cancer Research Fund (London)

Research and Academic Interests

  • Prostate Cancer and Benign Prostatic Hyperplasia
  • Tumor Microenvironment
  • Cellular Heterogeneity
  • Effects of Inflammatory Co-morbidities on Prostate Pathobiology
  • Application of Mathematical Modeling to Cancer Biology

Career Summary

Dr. Hayward performed his doctoral work at the Imperial Cancer Research Fund laboratories in London (now Cancer Research UK) where he worked on the development of models of human prostate biology. In 1992 he moved to the University of Californina, San Francisco to perform postdoctoral work under the guidance of Dr. Gerald Cunha. 

Dr. Hayward moved to Vanderbilt University Medical Center in 2001 as an Assistant Professor of Urologic Surgery and Cancer Biology. He was promoted to Associate Professor in 2005 and to Professor in 2011. Dr. Hayward was also the director of the Vanderbilt Benign Urologic Disease Center, which attempts to integrate research in the field of benign urology with the obesity and diabetes research communities on the Vanderbilt campus. He was also a member of the NCI Integrated Cancer Biology Program and the Tumor Microenvironment Network.

Dr. Hayward moved to NorthShore to take up a position as the Director of Cancer Biology in 2015. He brings many years of experience with in vitro and in vivo models of prostate cancer and benign prostatic hyperplasia, including use of tissue recombination models. Work in his laboratory is focused upon understanding the role of the tumor microenvironment, in particular fibroblasts and inflammatory cells, in prostate cancer progression and in dissecting the microenvironmental paracrine signaling pathways leading to benign prostatic hyperplasia and associated symptoms.

His work has been funded by grants from the NCI, NIDDK and the DOD-PCRP, with continuous personal research funding since 1997. He has served on many research panels, study sections and advisoryt boards.  

Honors and Awards

Dr. Hayward is a past-President of the Society for Basic Urologic Research.


Scholarly Work