Skip to Content

Ioannis Koktzoglou , PhD

Research Scientist II
Department of Radiology
Center for Advanced Imaging

Senior Clinician Researcher
University of Chicago, Pritzker School of Medicine

Contact Information

 847.570.2942 Fax


  • Undergraduate: BS, University of Illinois at Urbana-Champaign, 2002
  • Graduate: MS, Northwestern University, 2004
  • Post-Graduate: PhD, Northwestern University, 2006

Research and Academic Interests

  • Magnetic resonance imaging (MRI)
  • Imaging physics
  • Cardiovascular imaging
  • Neurovascular imaging
  • Angiography
  • Atherosclerosis
  • Novel imaging technologies

Career Summary

My research interests involve the development and application of next-generation magnetic resonance imaging (MRI) technologies for diagnosing and monitoring human disease. Areas of recent research focus include the development of accurate and robust MRI technologies for depicting cardiovascular disease without the use of injectible Gadolinium-based contrast agents, and approaches for quantifying cardiovascular disease and monitoring its response to therapy. I have served as faculty within the Feinberg School of Medicine at Northwestern University, as well as the Pritzker School of Medicine at the University of Chicago. 

Honors and Awards

  • Distinguished Reviewer, Magnetic Resonance in Medicine, 2011, 2014-2015, 2017
  • Distinguished Reviewer, Journal of Magnetic Resonance Imaging, 2012-2013, 2015, 2017
  • Early Career Reviewer Program, National Institutes of Health, 2015
  • Pohost Best Paper Award Finalist, Journal of Cardiovascular Magnetic Resonance, 2008
  • Research Scholar Award, The Auxiliary of Evanston Northwestern Healthcare, 2007-2009
  • Student Stipend Award, International Society for Magnetic Resonance in Medicine, 2004-2006
  • Invited Young Researcher, 55th Meeting of Nobel Prize Winners, Lindau, 2005
  • Dr. John N. Nicholson Fellowship, The Graduate School, Northwestern University, 2003-2006
  • Biomedical Engineering Departmental Fellowship, Northwestern University, 2002
  • High Honors Graduate, University of Illinois College of Engineering, 2002
  • Dad’s Association Book Award, University of Illinois at Urbana-Champaign, 2001
  • Accenture Outstanding Engineering Student Award, University of Illinois, 2001
  • Frank C. Mock Scholarship, University of Illinois at Urbana-Champaign, 2001
  • Jules D. Falzer Memorial Scholarship, University of Illinois at Urbana-Champaign, 2000-2001
  • AHEPA Scholarship, 1998-1999
  • Dean’s List, University of Illinois at Urbana-Champaign, 1998-2002

Professional Memberships/Affiliations/Activities

  • Member, International Society for Magnetic Resonance in Medicine, 2004-present
  • Member, Society for Cardiovascular Magnetic Resonance, 2007
  • Scientific Grant Reviewer, American Heart Association, 2013-2015

Scholarly Work

Peer-Reviewed Journal Publications:

  • Koktzoglou I, Edelman RR. Radial fast interrupted steady-state (FISS) magnetic resonance imaging. Magn Reson Med. 2018 Apr;79(4):2077-2086. doi: 10.1002/mrm.26881. Epub 2017 Aug 30. PubMed PMID: 28856788; PubMed Central PMCID: PMC5811387.
  • Edelman RR, Serhal A, Pursnani A, Pang J, Koktzoglou I. Cardiovascular cine imaging and flow evaluation using Fast Interrupted Steady-State (FISS) magnetic resonance. J Cardiovasc Magn Reson. 2018 Feb 19;20(1):12. doi: 10.1186/s12968-018-0433-3. PubMed PMID: 29458384; PubMed Central PMCID: PMC5819298.
  • Koktzoglou I, Edelman RR. Super-resolution intracranial quiescent interval slice-selective magnetic resonance angiography. Magn Reson Med. 2018 Feb;79(2):683-691. doi: 10.1002/mrm.26715. Epub 2017 May 3. PubMed PMID: 28470792; PubMed Central PMCID: PMC5670024.
  • Edelman RR, Carr M, Koktzoglou I. Advances in non-contrast quiescent-interval  slice-selective (QISS) magnetic resonance angiography. Clin Radiol. 2018 Jan 11.  pii: S0009-9260(17)30567-6. doi: 10.1016/j.crad.2017.12.003. [Epub ahead of print] Review. PubMed PMID: 29336780.
  • Lim RP, Trajcevska E, Al Rawi F, Gooneratne D, Ang W, Perchyonok Y, Fitt G, Kemp A, Giri S, Piccini D, Brodtmann A, Dewey H, Koktzoglou I. Noncontrast Hybrid Arterial Spin-Labeled Imaging of the Intracranial Arteries. J Comput Assist Tomogr. 2017 Nov/Dec;41(6):854-860. doi: 10.1097/RCT.0000000000000633. PubMed PMID: 28708731.
  • Edelman RR, Silvers RI, Thakrar KH, Metzl MD, Nazari J, Giri S, Koktzoglou I.  Nonenhanced MR angiography of the pulmonary arteries using single-shot radial quiescent-interval slice-selective (QISS): a technical feasibility study. J Cardiovasc Magn Reson. 2017 Jun 30;19(1):48. doi: 10.1186/s12968-017-0365-3. PubMed PMID: 28662717; PubMed Central PMCID: PMC5492118.
  • Ferreira Botelho MP, Koktzoglou I, Collins JD, Giri S, Carr JC, Gupta N, Edelman RR. MR imaging of iliofemoral peripheral vascular calcifications using proton density-weighted, in-phase three-dimensional stack-of-stars gradient echo. Magn Reson Med. 2017 Jun;77(6):2146-2152. doi: 10.1002/mrm.26295. Epub 2016 Jun 14. PubMed PMID: 27297954; PubMed Central PMCID: PMC5156593.
  • Hodnett PA, Koktzoglou I, Davarpanah AH, Scanlon TG, Collins JD, Sheehan JJ, Dunkle EE, Gupta N, Carr JC, Edelman RR. Evaluation of Peripheral Arterial Disease with Nonenhanced Quiescent-Interval Single-Shot MR Angiography. Radiology. 2017 Feb;282(2):614. doi: 10.1148/radiol.2017164042. PubMed PMID: 28099098.
  • Edelman RR, Botelho M, Pursnani A, Giri S, Koktzoglou I. Improved dark blood imaging of the heart using radial balanced steady-state free precession. J Cardiovasc Magn Reson. 2016 Oct 19;18(1):69. PubMed PMID: 27756330; PubMed Central PMCID: PMC5069874.
  • Koktzoglou I, Murphy IG, Giri S, Edelman RR. Quiescent interval low angle shot magnetic resonance angiography of the extracranial carotid arteries. Magn Reson Med. 2016 May;75(5):2072-7. doi: 10.1002/mrm.25791. Epub 2015 Jun 15. PubMed PMID: 26072706.
  • Koktzoglou I, Walker MT, Meyer JR, Murphy IG, Edelman RR. Nonenhanced hybridized arterial spin labeled magnetic resonance angiography of the extracranial carotid arteries using a fast low angle shot readout at 3 Tesla. J Cardiovasc Magn Reson. 2016 Apr 12;18:18. doi: 10.1186/s12968-016-0238-1. PubMed  PMID: 27067840; PubMed Central PMCID: PMC4828773.
  • Koktzoglou I, Giri S, Piccini D, Grodzki DM, Flanagan O, Murphy IG, Gupta N,  Collins JD, Edelman RR. Arterial spin labeled carotid MR angiography: A phantom study examining the impact of technical and hemodynamic factors. Magn Reson Med.  2016 Jan;75(1):295-301. doi: 10.1002/mrm.25611. Epub 2015 Feb 13. PubMed PMID: 25684192.
  • Edelman RR, Giri S, Pursnani A, Botelho MP, Li W, Koktzoglou I. Breath-hold imaging of the coronary arteries using Quiescent-Interval Slice-Selective (QISS)  magnetic resonance angiography: pilot study at 1.5 Tesla and 3 Tesla. J Cardiovasc Magn Reson. 2015 Nov 23;17:101. doi: 10.1186/s12968-015-0205-2. PubMed PMID: 26597281; PubMed Central PMCID: PMC4655490.
  • Edelman RR, Flanagan O, Grodzki D, Giri S, Gupta N, Koktzoglou I. Projection  MR imaging of peripheral arterial calcifications. Magn Reson Med. 2015 May;73(5):1939-45. doi: 10.1002/mrm.25320. Epub 2014 Jun 24. PubMed PMID: 24957402.
  • Lim RP, Koktzoglou I. Noncontrast magnetic resonance angiography: concepts and clinical applications. Radiol Clin North Am. 2015 May;53(3):457-76. doi: 10.1016/j.rcl.2014.12.003. Review. PubMed PMID: 25953284.
  • Koktzoglou I, Meyer JR, Ankenbrandt WJ, Giri S, Piccini D, Zenge MO, Flanagan O, Desai T, Gupta N, Edelman RR. Nonenhanced arterial spin labeled carotid MR angiography using three-dimensional radial balanced steady-state free precession  imaging. J Magn Reson Imaging. 2015 Apr;41(4):1150-6. doi: 10.1002/jmri.24640. Epub 2014 Apr 16. PubMed PMID: 24737420.
  • Edelman RR, Giri S, Murphy IG, Flanagan O, Speier P, Koktzoglou I. Ungated radial quiescent-inflow single-shot (UnQISS) magnetic resonance angiography using optimized azimuthal equidistant projections. Magn Reson Med. 2014 Dec;72(6):1522-9. doi: 10.1002/mrm.25477. Epub 2014 Sep 24. PubMed PMID: 25257379; PubMed Central PMCID: PMC4229423.
  • Koktzoglou I, Mistretta CA, Giri S, Dunkle EE, Amin P, Edelman RR. Simultaneous static and cine nonenhanced MR angiography using radial sampling and highly constrained back projection reconstruction. Magn Reson Med. 2014 Oct;72(4):1079-86. doi: 10.1002/mrm.25008. Epub 2013 Nov 11. PubMed PMID: 24407879; PubMed Central PMCID: PMC4016994.
  • Amin P, Collins JD, Koktzoglou I, Molvar C, Markl M, Edelman RR, Carr JC. Evaluating peripheral arterial disease with unenhanced quiescent-interval single-shot MR angiography at 3 T. AJR Am J Roentgenol. 2014 Apr;202(4):886-93. doi: 10.2214/AJR.13.11243. PubMed PMID: 24660721.
  • Tan H, Koktzoglou I, Prasad PV. Renal perfusion imaging with two-dimensional  navigator gated arterial spin labeling. Magn Reson Med. 2014 Feb;71(2):570-9. doi: 10.1002/mrm.24692. PubMed PMID: 23447145; PubMed Central PMCID: PMC4429520.
  • Edelman RR, Giri S, Dunkle E, Galizia M, Amin P, Koktzoglou I. Quiescent-inflow single-shot magnetic resonance angiography using a highly undersampled radial k-space trajectory. Magn Reson Med. 2013 Dec;70(6):1662-8. doi: 10.1002/mrm.24596. Epub 2013 Jan 24. PubMed PMID: 23348595; PubMed Central PMCID: PMC3638057.
  • Koktzoglou I. Gray blood magnetic resonance for carotid wall imaging and visualization of deep-seated and superficial vascular calcifications. Magn Reson  Med. 2013 Jul;70(1):75-85. doi: 10.1002/mrm.24445. Epub 2012 Aug 8. PubMed PMID:  22887594.
  • Koktzoglou I. 4D Dark blood arterial wall magnetic resonance imaging: methodology and demonstration in the carotid arteries. Magn Reson Med. 2013 Apr;69(4):956-65. doi: 10.1002/mrm.24647. Epub 2013 Feb 11. PubMed PMID: 23400824.
  • Offerman EJ, Koktzoglou I, Glielmi C, Sen A, Edelman RR. Prospective self-gated nonenhanced magnetic resonance angiography of the peripheral arteries. Magn Reson Med. 2013 Jan;69(1):158-62. doi: 10.1002/mrm.24240. Epub 2012 Mar 5. PubMed PMID: 22392645; PubMed Central PMCID: PMC3376657.
  • Mordini FE, Koktzoglou I, Edelman RR. Time-resolved spin-labeled balanced steady-state free precession cineangiography for visualizing intracardiac shunt:  technical considerations and clinical feasibility. Magn Reson Med. 2012 Dec;68(6):1798-806. doi: 10.1002/mrm.24191. Epub 2012 Mar 27. PubMed PMID: 22457224.
  • Tan H, Koktzoglou I, Glielmi C, Galizia M, Edelman RR. Optimization of single shot 3D breath-hold non-enhanced MR angiography of the renal arteries. J Cardiovasc Magn Reson. 2012 May 19;14:30. doi: 10.1186/1532-429X-14-30. PubMed PMID: 22607351; PubMed Central PMCID: PMC3419127.
  • Hodnett PA, Ward EV, Davarpanah AH, Scanlon TG, Collins JD, Glielmi CB, Bi X, Koktzoglou I, Gupta N, Carr JC, Edelman RR. Peripheral arterial disease in a symptomatic diabetic population: prospective comparison of rapid unenhanced MR angiography (MRA) with contrast-enhanced MRA. AJR Am J Roentgenol. 2011 Dec;197(6):1466-73. doi: 10.2214/AJR.10.6091. PubMed PMID: 22109304; PubMed Central PMCID: PMC3226789.
  • Koktzoglou I, Gupta N, Edelman RR. Nonenhanced extracranial carotid MR angiography using arterial spin labeling: improved performance with pseudocontinuous tagging. J Magn Reson Imaging. 2011 Aug;34(2):384-94. doi: 10.1002/jmri.22628. PubMed PMID: 21780230.
  • Hodnett PA, Koktzoglou I, Davarpanah AH, Scanlon TG, Collins JD, Sheehan JJ,  Dunkle EE, Gupta N, Carr JC, Edelman RR. Evaluation of peripheral arterial disease with nonenhanced quiescent-interval single-shot MR angiography. Radiology. 2011 Jul;260(1):282-93. doi: 10.1148/radiol.11101336. Epub 2011 Apr 18. PubMed PMID: 21502384; PubMed Central PMCID: PMC3121010.
  • Offerman EJ, Hodnett PA, Edelman RR, Koktzoglou I. Nonenhanced methods for lower-extremity MRA: a phantom study examining the effects of stenosis and pathologic flow waveforms at 1.5T. J Magn Reson Imaging. 2011 Feb;33(2):401-8. doi: 10.1002/jmri.22457. PubMed PMID: 21274982; PubMed Central PMCID: PMC3210566.
  • Koktzoglou I, Sheehan JJ, Dunkle EE, Breuer FA, Edelman RR. Highly accelerated contrast-enhanced MR angiography: improved reconstruction accuracy and reduced noise amplification with complex subtraction. Magn Reson Med. 2010 Dec;64(6):1843-8. doi: 10.1002/mrm.22567. PubMed PMID: 20860003.
  • Haque M, Koktzoglou I, Li W, Carbray J, Prasad P. Functional MRI of liver using BOLD MRI: effect of glucose. J Magn Reson Imaging. 2010 Oct;32(4):988-91. doi: 10.1002/jmri.22329. PubMed PMID: 20882631.
  • McCommis KS, Koktzoglou I, Zhang H, Goldstein TA, Northrup BE, Li D, Gropler  RJ, Zheng J. Improvement of hyperemic myocardial oxygen extraction fraction estimation by a diffusion-prepared sequence. Magn Reson Med. 2010 Jun;63(6):1675-82. doi: 10.1002/mrm.22427. PubMed PMID: 20512871; PubMed Central  PMCID: PMC2917901.
  • Wu Y, Ragin AB, Du H, Sidharthan S, Dunkle EE, Koktzoglou I, Edelman RR. Sub-millimeter isotropic MRI for segmentation of subcortical brain regions and brain visualization. J Magn Reson Imaging. 2010 Apr;31(4):980-6. doi: 10.1002/jmri.22120. PubMed PMID: 20373444; PubMed Central PMCID: PMC3186681.
  • Edelman RR, Sheehan JJ, Dunkle E, Schindler N, Carr J, Koktzoglou I. Quiescent-interval single-shot unenhanced magnetic resonance angiography of peripheral vascular disease: Technical considerations and clinical feasibility. Magn Reson Med. 2010 Apr;63(4):951-8. doi: 10.1002/mrm.22287. PubMed PMID: 20373396; PubMed Central PMCID: PMC2896273.
  • Tsaftaris SA, Offerman E, Edelman RR, Koktzoglou I. Fully automated reconstruction of ungated ghost magnetic resonance angiograms. J Magn Reson Imaging. 2010 Mar;31(3):655-62. doi: 10.1002/jmri.22092. PubMed PMID: 20187209.
  • Dharmakumar R, Zhang Z, Koktzoglou I, Tsaftaris SA, Li D. Dual-contrast cellular magnetic resonance imaging. Mol Imaging. 2009 Sep-Oct;8(5):254-63. PubMed PMID: 19796603.
  • Edelman RR, Koktzoglou I, Ankenbrandt WJ, Dunkle EE. Cerebral venography using fluid-suppressed STARFIRE. Magn Reson Med. 2009 Aug;62(2):538-43. doi: 10.1002/mrm.22026. PubMed PMID: 19365867.
  • Koktzoglou I, Edelman RR. Ghost magnetic resonance angiography. Magn Reson Med. 2009 Jun;61(6):1515-9. doi: 10.1002/mrm.21943. PubMed PMID: 19319899.
  • Edelman RR, Dunkle E, Koktzoglou I, Griffin A, Russell EJ, Ankenbrandt W, Ragin A, Carrillo A. Rapid whole-brain magnetic resonance imaging with isotropic  resolution at 3 Tesla. Invest Radiol. 2009 Jan;44(1):54-9. doi: 10.1097/RLI.0b013e31818eee3c. PubMed PMID: 19060723.
  • Koktzoglou I, Edelman RR. STAR and STARFIRE for flow-dependent and flow-independent noncontrast carotid angiography. Magn Reson Med. 2009 Jan;61(1):117-24. doi: 10.1002/mrm.21769. PubMed PMID: 19097217.
  • Edelman RR, Koktzoglou I. Unenhanced flow-independent MR venography by using  signal targeting alternative radiofrequency and flow-independent relaxation enhancement. Radiology. 2009 Jan;250(1):236-45. doi: 10.1148/radiol.2493080496. PubMed PMID: 19092096.
  • Koktzoglou I, Edelman RR. Fast projective carotid MR angiography using arterial spin-labeled balanced SSFP. J Magn Reson Imaging. 2008 Sep;28(3):778-82. doi: 10.1002/jmri.21476. PubMed PMID: 18777548.
  • Dharmakumar R, Koktzoglou I, Tang R, Harris KR, Beohar N, Li D. Off-resonance positive contrast imaging of a passive endomyocardial catheter in swine. Phys Med Biol. 2008 Jul 7;53(13):N249-57. doi: 10.1088/0031-9155/53/13/N02. Epub 2008 Jun  19. PubMed PMID: 18562781.
  • Koktzoglou I, Kirpalani A, Carroll TJ, Li D, Carr JC. Dark-blood MRI of the thoracic aorta with 3D diffusion-prepared steady-state free precession: initial clinical evaluation. AJR Am J Roentgenol. 2007 Oct;189(4):966-72. PubMed PMID: 17885072.
  • Koktzoglou I, Li D, Dharmakumar R. Dephased FLAPS for improved visualization  of susceptibility-shifted passive devices for real-time interventional MRI. Phys  Med Biol. 2007 Jul 7;52(13):N277-86. Epub 2007 May 25. PubMed PMID: 17664566.
  • Dharmakumar R, Koktzoglou I, Li D. Factors influencing fast low angle positive contrast steady-state free precession (FLAPS) magnetic resonance imaging. Phys Med Biol. 2007 Jun 7;52(11):3261-73. Epub 2007 May 15. PubMed PMID: 17505101.
  • Koktzoglou I, Li D. Submillimeter isotropic resolution carotid wall MRI with  swallowing compensation: imaging results and semiautomated wall morphometry. J Magn Reson Imaging. 2007 Apr;25(4):815-23. PubMed PMID: 17345637.
  • Koktzoglou I, Chung YC, Carroll TJ, Simonetti OP, Morasch MD, Li D. Three-dimensional black-blood MR imaging of carotid arteries with segmented steady-state free precession: initial experience. Radiology. 2007 Apr;243(1):220-8. PubMed PMID: 17392255.
  • Koktzoglou I, Li D. Diffusion-prepared segmented steady-state free precession: Application to 3D black-blood cardiovascular magnetic resonance of the thoracic aorta and carotid artery walls. J Cardiovasc Magn Reson. 2007;9(1):33-42. PubMed PMID: 17178678.
  • Dharmakumar R, Koktzoglou I, Li D. Generating positive contrast from off-resonant spins with steady-state free precession magnetic resonance imaging:  theory and proof-of-principle experiments. Phys Med Biol. 2006 Sep 7;51(17):4201-15. Epub 2006 Aug 8. PubMed PMID: 16912377.
  • Koktzoglou I, Chung YC, Mani V, Carroll TJ, Morasch MD, Mizsei G, Simonetti OP, Fayad ZA, Li D. Multislice dark-blood carotid artery wall imaging: a 1.5 T and 3.0 T comparison. J Magn Reson Imaging. 2006 May;23(5):699-705. PubMed PMID:  16555260.
  • Koktzoglou I, Harris KR, Tang R, Kane BJ, Misselwitz B, Weinmann HJ, Lu B, Nagaraj A, Roth SI, Carroll TJ, McPherson DD, Li D. Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine. Invest Radiol. 2006 Mar;41(3):299-304. PubMed PMID: 16481913.
  • Koktzoglou I, Simonetti O, Li D. Coronary artery wall imaging: initial experience at 3 Tesla. J Magn Reson Imaging. 2005 Feb;21(2):128-32. PubMed PMID:  15666403.  

 U.S. Patents:

  • “System and Method for Ghost Magnetic Resonance Imaging”
    United States Patent 8,154,287.  Issued 4/10/2012.
  • “Parallel-Accelerated Complex Subtraction MRI”
    United States Patent 8,274,284.  Issued 9/25/2012.
  • “Time Resolved Spin Labeled MRI Cineangiography”
    United States Patent 8,441,257.  Issued 5/4/2013.
  • “Method for Non-Contrast Enhanced Magnetic Resonance Angiography”
    United States Patent 8,744,551.  Issued 6/3/2014.
  • "System and Method for Phase Contrast Imaging with Improved Efficiency"
    United States Patent 8,838,204.  Issued 9/16/2014.
  • “System and Method for Ungated Non-Contrast Enhanced Magnetic Resonance Angiography”
    United States Patent 9,113,810.  Issued 8/25/2015.
  • “System and Method for Imaging of Vascular Structures Using Non-Contrast Enhanced Magnetic Resonance Imaging”
    United States Patent 9,507,003.  Issued 11/29/2016.

Selected Book Chapters:

  • I. Koktzoglou, R.P. Lim, O. Flanagan and R.R. Edelman. “Non-contrast Enhanced MRA,” In Basic Principles of Cardiovascular MRI - Physics and Imaging Techniques, M. Syed, S. Raman and O.P. Simonetti, eds, Springer-Verlag, London, UK, 2015.
  • M. Miyazaki, S. Sugiura, Y. Kassai, H. Kanazawa, RR. Edelman and I. Koktzoglou. “Flow-Dependent Noncontrast MR Angiography,” In Magnetic Resonance Angiography: Principles and Applications, J.C. Carr and T.J. Carroll, eds, Springer, New York, NY. 2011.
  • I. Koktzoglou, J.C. Carr, T.J. Carroll, M.D. Morasch and D. Li. “Magnetic Resonance Imaging of Atherosclerotic Plaque,” In Modern Trends in Vascular Surgery: Carotid Artery Disease, M.K. Eskandari, W.H. Pearce, J. Yao, eds, People’s Medical Publishing House, Shelton, CT. 2010.

Peer Review Service:

  • Reviewer for multiple scientific journals, including:  Magnetic Resonance in Medicine, Journal of Magnetic Resonance Imaging, Journal of Cardiovascular Magnetic Resonance, Radiology, Circulation: Cardiovascular Imaging, American Journal of Roentgenology, Magn. Reson. Materials in Physics Biology & Medicine, PLOS ONE, NMR in Biomedicine, Clinical Medicine Cardiology, European Journal of Nuclear Medicine and Molecular Imaging, Korean Journal of Radiology