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Amniocentesis is a test to look at the fluid that surrounds your baby (fetus) in the uterus. Amniotic fluid has cells and other substances that can give clues about the health of your fetus.
For this test, a needle is put gently through your belly into your uterus. About 2 Tbsp (30 mL) of fluid is taken out and looked at.
This test may be done between weeks 15 and 20 to look at the baby's genes. It can also be used later in pregnancy.
Amniocentesis is often done around week 16 to see if a fetus has certain genetic conditions. It can also tell the sex of a fetus and help find certain neural tube defects.
Amniotic fluid has cells that have been shed by your growing fetus. The cells are checked for the number and size of chromosomes. This can show if there are any problems that put the baby at risk for certain conditions, such as Down syndrome. But this test can't find many common birth defects, such as cleft lip, cleft palate, or heart problems.
Testing is most often done as soon as possible so women and their families have time to think about their options.
This test may also be done later in pregnancy if your doctor thinks you may have an infection of the amniotic fluid (chorioamnionitis).
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Amniocentesis may be done during your second trimester to find certain genetic conditions as well as neural tube defects.
You may choose to have this test because:
Amniocentesis can tell the sex of your baby. This is important when you or the father may pass on a disease that occurs mainly in one sex (sex-linked). Examples include hemophilia and Duchenne muscular dystrophy. These both occur mainly in males.
Amniocentesis may also be done to:
You may want to talk to a genetic counselor before or after the test. This person is trained to give you detailed information about the test. The counselor can help you make decisions about testing. The counselor can also help you understand the results of the tests.
You will be asked to sign a consent form that says you understand the risks of the test and agree to have it done.
Amniocentesis is done by your obstetrician in the doctor's office or in the hospital. You probably won't need to stay overnight in the hospital unless problems occur during the test.
You will lie on your back on an exam table. Your belly will be cleaned with an antiseptic.
Your doctor will use a fetal ultrasound to check the position of your fetus and the placenta. Ultrasound uses sound waves to make a picture of the uterus, your fetus, and the placenta on a TV screen. Your fetus's heart rate can also be watched during the test using ultrasound.
With the ultrasound picture as a guide, your doctor will gently put a thin needle through your belly and into your uterus. This will not hurt your fetus or the placenta. If your fetus moves too close to the needle, the doctor will take the needle out and try again in another spot.
The doctor will take about 2 Tbsp (30 mL) of amniotic fluid. Then the needle is removed. The site is covered with a bandage.
Your fetus's heart rate and your blood pressure, pulse, and breathing will be checked before, during, and after the test.
The test will take about 15 minutes. The thin needle is in your belly for only 1 to 2 minutes.
You may feel a sharp sting or burn in your belly where the needle is put in. This lasts for only a few seconds. When the needle is put into your uterus, you may feel a sharp cramp for a few seconds.
When the amniotic fluid is taken out, you may get a feeling of pulling or pressure in your belly. To keep yourself comfortable, breathe slowly and relax your belly muscles during the test.
Some risks of amniocentesis may include:
Amniocentesis has a very small risk of causing bleeding that could mix your blood and your fetus's blood. So if you have Rh-negative blood, you will be given the Rh immunoglobulin shot (such as RhoGAM). This can prevent Rh sensitization, which could cause harm if your baby has Rh-positive blood.
Normal amniotic fluid is clear to light yellow in color and does not contain any harmful bacteria. The cells can be tested for problems.
Normal results from amniocentesis do not guarantee that your baby will be healthy.
CitationsSalomon LJ, et al. (2019). Risk of miscarriage following amniocentesis or chorionic villus sampling: Systematic review of literature and updated meta-analysis. Ultrasound in Obstetrics and Gynecology : The Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, 54(4): 442–451. DOI: 10.1002/uog.20353. Accessed July 27, 2020.
Current as of: July 11, 2023
Author: Healthwise StaffClinical Review BoardAll Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.
Current as of: July 11, 2023
Author: Healthwise Staff
Clinical Review BoardAll Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.
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