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Education

  • Undergraduate: 
    • Diploma in Immunology, University of Science and Technology of Sfax, Tunisia
    • Diploma in Molecular Genetics, University of Science of Tunis, Tunisia
    • Diploma of Human Genetic, University Rene Descarte Paris, France 
  • Medical School: Medical Doctorate degree, Facultée de Medecine de Sfax, Tunisia
  • Internship: 
    • University Hospitals of Sfax, Tunisia
    • Department of Medicine, Northwestern Memorial Hospital, Chicago
  • Residency: 
    • Hospital Kremlin-Bicètre, Paris, France
    • University Hospitals and National Institute of Neurology, Tunisia
    • Department of Neurology, Northwestern Memorial Hospital, Chicago
  • Fellowship: 
    • Unitée de Recherche 12, INSERM - Hopital Des Enfants Malades, Paris, France
    • Neurogenetic Laboratory, Department of Neurology, Northwestern University Medical School, Chicago, Illinois

Board Certification

  • Neurology

Research and Academic Interests

  • Multiple Sclerosis

Professional Memberships/Affiliations/Activities

  • American Academy of Neurology

Scholarly Work

Publications in Peer-Review Journals:

  1. Hentati A. (1989).  Contribution à l'etude des paraplegies spasmodiques et familiales pûres (strumpell-Lorrain) et associées en Tunisie.  Thesis for Doctorate in Medicine, Faculté de Medecine de Sfax (Tunisia).
  2. Kaplan J, Pelet A, Hentati A, Jeanpierre M, Briad ML, Journel H, Munnich A, and Duffier JL. (1991). Contribution to carrier detection and genetic conselling in x-linked retinoschisis.  J. Med. Genet., 28:383-388.  [*Note*: My name appears in the publication as Hentati H.]
  3. Hentati A, Lamy C, Melki J, Zuber M, Mumich A, and DeRecondo J. (1992). Clinical and genetic heteogeneity of charcot-Marie-Tooth disease.  Genomics 12:155-157.
  4. Hentati A, Hu P, Asgharzadeh S and Siddique T.  (1992) Dinucleotide repeat polymorphism at the human erythroid alpha spectrin (SPTA1) locus.  Human Molecular Genetics, 1:218.
  5. Rosen DR, Siddique T, Patterson D, Figlewicz A, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HG, et al.  (1993)  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.  Nature, 362:59-62.
  6. Deng H-X, Hentati A, Tainer J, Iqbal Z, Cayabyab A, Hung W-Y, Getzoff ED, Hu P, Herzfeldt B, Roos RP, Warner C, Deng G, Soriano E, Smyth C, Parge HE, Ahmed A, Roses AD, Hallewell R, Pericak-Vance MA, and Siddique T. (1993)  Amyotrophic Lateral Sclerosis and Structural Defects in Cu, Zn Superoxide Dismutase. Science, 261: 1047-1051.
  7. Hentati A, Bejaoui K, Pericak-Vance MA, Hentati F, Hung W-Y, Figlewicz DA, Ben Hamida C, Ben Hamida M, Brown Jr. RH and Siddique T.  (1994). Linkage of recessive familial amyotrophic lateral sclerosis (ALS2) to chromosome 2q33-q35.  Nature Genetics, 7:425-428.
  8. Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, Caliendo J, Hentati A, Kwon YW, Deng HX, Chen W, Zhai P, Sufit RL and Siddique T. (1994). Motor neuron degeneration in mice expressing a human Cu,Zn superoxide dismutase mutation. Science, 264:1772-1775.
  9. Hentati A, Pericak-Vance MA, Hung WY, Balal S, Laing N, Hentati F, Ben Hamida M, and Siddique T. (1994). Linkage of “pure” autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus heterogeneity.  Human Molecular Genetics, 3:1263-1267.
  10. Hentati A, Pericak-Vance MA, Lennon F, Wasserman B, Hentati F, Juneja T, Angrist MH, Hung WY, Boustany RM, Bohlega S, Iqbal Z, Huether CH, Ben Hamida M, Siddique T.  (1994). Linkage of a locus for autosomal dominant familial spastic paraplegia to chromosome 2p markers.  Human Molecular Genetics, 3:1867-1871.
  11. Deng HX, Tainer JA, Mitsumoto H, Ohnishi A, He X, Hung WY, Zhao Y, Juneja T, Hentati A, and Siddique T.  (1995). Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis.  Human Molecular Genetics, 4:113-1116.
  12. Hentati A, Deng HX, Hung WY, Nayer M, Ahmed MS, Tim R, He X, Stumpf DA, and Siddique T.  (1996). Human a-tocopherol transfer protein: Gene organization and identification of mutations in familial vitamin E deficiency. Annals of Neurology, 39:295-300.
  13. Isozumi K, DeLong R, Kaplan J, Deng H-X, Iqbal Z, Hung W-Y, Wilhemsen KC, Hentati A, Pericak-vance MA, and Siddique T. (1996). Linkage of scapuloperoneal spinal muscular atrophy to chromosome 12q24.1-q24.31. Human Molecular Genetics, 5:1377-1382.
  14. Ahmed MS, Afsar S, Hentati A, Ahmad A, Pasha J, Juneja T, hung W-Y, Ahmad A, Choudhri AN, Saya S, and Siddique T. (1997). A novel mutation in 27-Hydroxilse gene of a Pakistani family with autosomal recessive cerebrotendinous xanthomatosis (CTX). Neurology, 48:258-260
  15. Hentati A, Ouahchi K, Pericak-Vance MA, Nijhawan D, Ahmad A, Yang Y, Rimmler J, Hung W-Y, Schlotter B, Ahmed A, Ben Hamida M, Siddique T. (1998). Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers. Neurogenetics, 2:55-60
  16. Hentati A, Deng H-X, Zhai H, Chen W,  Yang Y, Hung W-Y, Azim A C, Bohlega S, Tandan R, Warner C, Laing N G, Cambi F, Mitsumoto H, Roos R P, Boustany R M, Ben Hamida M, Hentati F, and Siddique T. (2000). Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. Neurology, 55:1388-90
  17. Yang Y, Hentati A, Deng HX, Dabbagh O, Sasaki T, Hirano M, Hung WY, Ouahchi K, Yan J, Azim AC, Cole N, Gascon G, Yagmour A, Ben-Hamida M, Pericak-Vance M, Hentati F, Siddique T. (2001) The gene enoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat Genet 2001 29(2):160-5.

Publications

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