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Anand Srinivasan, M.D.

Anand Srinivasan, M.D.

Anand Srinivasan, M.D.

Minimally Invasive Custom Hip and Knee Replacement
  • Locations

    NorthShore Medical Group

    920 Milwaukee Ave.
    Lincolnshire, IL 60069
    847.866.7846 866.954.5866 fax Get Directions This location is wheelchair accessible.

    NorthShore Medical Group

    7900 Rollins Rd.
    Suite 1400
    Gurnee, IL 60031
    847.866.7846 866.954.5866 fax Get Directions This location is wheelchair accessible.
  • Publications
    • Safety and efficacy of epsilon aminocaproic acid (EACA) as an antihemorrhagic drug in bilateral one stage total knee arthroplasty: A double-blind randomized controlled trial.

      The Knee 2020 Jan

      Authors: Tripathy SK, Rao PB, Nanda SN, Nayak C, Samal BP, Jain M, Srinivasan A, Hota D
      Antifibrinolytic drugs are widely used to minimize blood loss and transfusion requirements in total knee arthroplasty (TKA). Although tranexamic acid (TXA) has been widely studied for its use in TKA, there are limited studies on epsilon-aminocaproic acid (EACA).
      In a double-blind randomized control trial, all patients (n = 91) operated with bilateral simultaneous TKA were randomly given either intravenous EACA or placebo (normal saline). A single surgeon performed the TKA with posterior-stabilized implants under tourniquet. A suction drain was placed and kept for 48 h postoperatively. The intraoperative blood loss and drain output were calculated. The postoperative hemoglobin (Hb), drop in Hb, total blood loss, and number of blood transfusions in each group were calculated.
      Both of the groups were comparable in terms of age, sex, body mass index, and pre-operative Hb. There was a significant difference between the EACA group and control group in terms of intraoperative blood loss (150 ml vs. 165 ml, P = 0.01), drain output (494 ml vs. 1062 ml, P < 0.001), postoperative Hb (9.9 g/dl vs. 8.6 g/dl, P = 0.002), drop in Hb (2.2 g/dl vs. 3.1 g/dl, P = 0.026) and transfusion rate (median transfusion 0 vs. 1, P < 0.001). The total blood loss, as calculated by the Hb balance method, was significantly less (P < 0.001) in the EACA group (0.99 l) compared with the control group (2.71 l). None of the patients developed any adverse reaction/complication to the drug.
      Intraoperative administration of EACA significantly decreased the blood loss and postoperative transfusion rates compared with no antifibrinolytic therapy in bilateral simultaneous TKA.
      PMID: 31882387 [PubMed - as supplied by publisher]
    • Effect of silver nanoparticle geometry on methicillin susceptible and resistant Staphylococcus aureus, and osteoblast viability.

      Journal of materials science. Materials in medicine 2015 Jul

      Authors: Actis L, Srinivasan A, Lopez-Ribot JL, Ramasubramanian AK, Ong JL
      Orthopedic implant failure as a result of bacterial infection affects approximately 0.5-5% of patients. These infections are often caused by Staphylococcus aureus which is capable of attaching and subsequently forming a biofilm on the implant surface, making it difficult to eradicate with systemic antibiotics. Further, with the emergence of antibiotic-resistant bacteria, alternative treatments are necessary. Silver nanoparticles have received much attention for their broad spectrum antibacterial activity which has been reported to be both size and shape dependent. The purpose of this study was therefore to evaluate the effect of three different geometries on their effect on microbial susceptibility as well as evaluate their effect on bone cell viability. Silver nanoparticles of spherical, triangular and cuboid shapes were synthesized by chemical reduction methods. The susceptibility of S. aureus and methicillin-resistant S. aureus was evaluated a 24 h period and determined using a colorimetric assay. Further, the viability of human fetal osteoblast (hFOB) cells in the presence of the silver nanoparticles was evaluated over a period of 7 days by AlmarBlue fluorescence assay. hFOB morphology was also evaluated by light microscopy imaging. Results indicated that silver nanoparticle geometry did not have an effect on microbiota susceptibility or hFOB viability. However, high concentrations of silver nanoparticles (0.5 nM) conferred significant susceptibility towards the bacteria and significantly reduced hFOB viability. It was also found that the hFOBs exhibited an increasingly reduced viability to lower silver nanoparticle concentrations with an increase in exposure time.
      PMID: 26194976 [PubMed - as supplied by publisher]
    • Modularity of the femoral component in total hip arthroplasty.

      The Journal of the American Academy of Orthopaedic Surgeons 2012 Apr

      Authors: Srinivasan A, Jung E, Levine BR
      Modular femoral components have been developed to aid in recreating native femoral version, limb length, and offset in total hip arthroplasty. Use of modular implants results in cost savings, as well. Inventory can be reduced while allowing intraoperative flexibility and options. With modular implants, the femoral prosthesis can be built in situ, which is helpful in minimizing incision length and surgical dissection. However, additional modular junctions are associated with increased concern for component failure through taper fretting, fatigue fracture, and local corrosion, which may contribute to elevated serum metal ion levels. The recent trend toward using larger diameter femoral heads may impart higher loads and stress than were seen previously. Although modular components offer a plethora of intraoperative options in primary and revision total hip arthroplasty, the long-term effects of these additional junctions remains unknown.
      PMID: 22474091 [PubMed - as supplied by publisher]
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    In the News

    Jul 2019

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