HCN Tissue Bank: Tissue/Body Fluid Procurement and Clinical Data Collection for Patients with Malignancies of the Head and Neck Area and/or Pre-Malignant Changes
Aims: The purpose of this study is to collect tissue, blood, saliva, and/or clinical data (information about your treatment) from patients with a cancer in the head and neck area (or pre-malignant lesions) for research purposes. Certain genetic and biochemical changes are believed to lead to the development of head and neck cancer. Scientists are attempting to discover and understand the function of these changes. In the future, improved understanding of these changes may help us to better detect head and neck cancers and offer improved treatments.
Principal Investigator: Nicholas Campbell, MD
IRB Approval Number: EH13-276
Sponsor: NorthShore University HealthSystem
Contact: Interested patients should contact research nurse Elita Fine, RN at 847.570.2698
Open to Enrollment: Yes

RTOG-1216: Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin versus Docetaxel versus Docetaxel and Cetuximab for High-Risk Squamous Cell cancer of the Head and Neck
Aims: The purpose of the this part of this study is to find out what effects, good and/or bad, one of the following treatments has on you and your cancer. In this part of the study, you will receive one of the following treatments:

  • Standard treatment: radiation therapy and cisplatin
  • Experimental treatment: radiation therapy and docetaxel
  • Experimental treatment: radiation therapy, docetaxel, and cetuximab

Principal Investigator: Bruce Brockstein, MD
IRB Approval Number: EH15-004
Sponsor: Radiation Therapy Oncology Group
Contact: Interested patients should contact research nurse Elita Fine, RN at 847.570.2698
Open to Enrollment: Yes

AstraZeneca D419LC00001: A Phase III, Randomized, Open-Label, Multi-center, Global Study of MEDI4736 Alone or in Combination with Tremelimumab Versus Standard of Care in the Treatment of First-Line Recurrent or Metastatic Squamous Cell Head and Neck Ckancer Patients (KESTREL)
Aims: This study is being carried out to see if an experimental anti-cancer drug called MEDI4736 or the combination of MEDI4736 and tremelimumab are effective in treating the type of cancer that you have. Both drugs are antibodies that has been made in the laboratory that may boost the ability of the immune system to detect and fight cancer.
Principal Investigator: Nicholas Campbell, MD
IRB Approval Number: EH16-052
Sponsor: AstraZeneca
Contact: Interested patients should contact research nurse Elita Fine, RN at 847.570.2698
Open to Enrollment: Yes

AstraZeneca D4193C00002 : A Phase III, Randomized, Open-Label, Multi-center, Global Study of MEDI4736 Monotherapy and MEDI4736 in Combination with Tremelimumab  Versus Standard of Care Therapy in Patients with Recurrent or Metastatic Squamous cell Carcinoma of the Head and Neck (SCCHN)
Aims: The study is being carried out to see if the experimental treatment of MEDI4736 monotherapy or MEDI4736 with Tremelimumab are better than standard of care treatments 
Principal Investigator: Bruce Brockstein, MD
IRB Approval Number: EH15-154
Sponsor: AstraZeneca
Contact: Interested patients should contact research nurse Elita Fine, RN at 847.570.2698, efine@northshore.org
Open to Enrollment: Yes  

MK-3475-048-01: A Phase 3 Clinical Trial of Pembrolizumab (MK-3475) in First Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Aims: This study is being carried out to see if an experimental anti-cancer drug called MEDI4736 (study drug) and tremelimumab are effective in treating the type of cancer that you have.
Principal Investigator: Nicholas Campbell, MD
IRB Approval Number: EH15-350
Sponsor: Merck
Contact: Interested patients should contact research nurse Elita Fine, RN at 847.570.2698
Open to Enrollment: Yes