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Jerrold Blair Leikin, M.D.

Jerrold Blair Leikin, M.D.

Jerrold Blair Leikin, M.D.

Medical Toxicology, Internal Medicine, Emergency Medicine
  • Locations
    Locations
    A

    NorthShore Medical Group

    2150 Pfingsten Rd.
    Suite 3000
    Glenview, IL 60026
    847.657.1700 847.657.1711 fax Get Directions This location is wheelchair accessible.
  • Publications
    Publications
    • Renal complications during pregnancy: In the hypertension spectrum.

      Disease-a-month : DM 2018 Mar 08

      Authors: Ho JH, Leikin JB
      Abstract
      There have been concerns about prosthesis failure and the potential for systemic toxicity due to release of cobalt and chromium from metal-on-metal hip joint prostheses (MoM-HP). There is conflicting evidence on whether there is a correlation between higher cobalt and chromium concentrations and systemic toxicity.
      We undertook a retrospective review of consecutive patients with MoM-HP referred for outpatient review in toxicology clinics in London, UK, and in the USA recorded in the Toxicology Investigators Consortium (ToxIC) Registry from June 2011 to June 2015.
      Thirty-one cases were identified; the median (IQR) serum cobalt concentration was 10.0 (3.8-32.8) mcg/L, and the median (IQR) serum chromium concentration was 6.9 (3.7-18.7) mcg/L. Twenty-three (74.2%) had symptoms, most commonly lethargy, hearing loss, and tinnitus. The odds ratios of symptomatic/asymptomatic patients for metal ion concentrations above/below 7 mcg/L were 1.87 (95% CI 0.37-9.57, p = 0.45) and 0.60 (95% CI 0.10-3.50, p = 0.57) for cobalt and chromium, respectively. Two (6.5%) patients with systemic cobalt toxicity had median (IQR) serum cobalt concentrations significantly higher than those without systemic features (630.4 [397.6-863.2] mcg/L versus 9.8 [2.9-16.4] mcg/L; p = 0.017). However, overall, there were no differences between cobalt (p = 0.38) or chromium (p = 0.92) concentrations between symptomatic and asymptomatic patients and no clinical features or investigation results correlated with cobalt or chromium concentration.
      Two (6.5%) of 31 individuals referred for assessment of MoM-HP were diagnosed with systemic cobalt toxicity. However, despite a high prevalence of reported symptoms, neither symptoms nor investigation results correlated with serum cobalt or chromium concentrations.
      PMID: 29526394 [PubMed - as supplied by publisher]
    • Clinical hypertension: Blood pressure variability.

      Disease-a-month : DM 2018 Jan

      Authors:
      Abstract
      PMID: 28826741 [PubMed - as supplied by publisher]
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