Demetrius M. Maraganore, MDMedical Director, NorthShore Neurological Institute
Chairman, Department of Neurology

Contact Information
847.570.1678
847.570.1934 fax
dmaraganore@northshore.org

Education

  • Undergraduate: Northwestern University (Honors Program in Medical Education); Bachelor's of Science Degree, 1983.
  • Medical School: Northwestern University Medical School; Doctor of Medicine, 1985.
  • Internship: Honorary Clinical Research Fellow in Movement Disorders to Professor C.D. Marsden, The National Hospital for Nervous Disorders, Queen Square, London, England, July 1989 - July 1990.
  • Residency: Mayo Graduate School of Medicine; Internal Medicine, June 1985 - June 1986; Neurology, July 1986 - June 1989.

Research Interests

  • Parkinson’s disease
  • Molecular epidemiology
  • Complex genetics
  • Molecular prognostics
  • Molecular therapeutics

Honors and Awards

  • Mayo Foundation scholarship, July 1989 - July 1990.
  • Movement Disorders Society, International Executive Committee, Member (by election), 2007-2010.
  • Recipient of the Paul Silverstein Community Service Award for Outstanding Contributions to the Parkinson's Community, 2007.
  • Visiting Professor faculty appointment, University of Milano-Biocca, 2009

Professional Memberships/Affiliations/Activities

  • American Academy of Neurology, Member
  • American Academy of Neurology, Movement Disorders Section, Member
  • American Medical Association, Member
  • Minnesota State Medical Society, Member
  • Zumbro Valley Medical Society, Member
  • Movement Disorders Society, Member

Scholarly Work

Publications in Peer-Review Journals:

  1. McDonnell SK, Schaid DJ, Elbaz A, Strain KJ, Bower JH, Ahlskog JE, Maraganore DM, Rocca WA.  "Complex Segregation Analysis of Parkinson's Disease:  The Mayo Clinic Family Study."  Annals of Neurology 2006;59:788-795.
  2. Bower JH, Maraganore DM, Peterson BJ, Ahlskog JE, Rocca WA.  "Immunological Diseases, Anti-Inflammatory Drugs, and Parkinson's Disease:  A Case-Control Study."  Neurology 2006;67:494-496.
  3. Ioannidis JPA, Gwinn ML, Little J, Higgins JPT, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley pE, Buffler PA, Casas JP, Chokkalingam A, Danesh J, Smith GD, Dolan S, Duncan R, Gruis NA, Hartge P, Hashibe M, Hunter D, Jarvelin M-R, Malmer B, Manolio T, Maraganore DM, Newton-Bishop JA, O'Brien TR, Petersen G, Riboli E, Salanti G, Seminara D, Smeeth L, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Khoury MJ and the Human Genome Epidemiology Network and the Network of Investigator Networks.  "A Road Map for Efficient and Reliable Human Genome Epidemiology."  Nature Genetics 2006;38:3-5.
  4. Maraganore DM, de Andrade M, Elbaz A, Farrer MJ, Ioannidis JP, Kruger R, Rocca WA, Schneider NK, Lesnick TG, Lincoln SJ, Hulihan MM, Aasly JO, Ashizawa T, Chartier-Harlin M-C, Checkoway H, Ferrarese C, Hadjigeorgiou G, Hattori N, Kawakami H, Lambert J-C, Lynch T, Mellick GD, Papapetropoulos S, Parsian A, Quattrone A, Riess O, Tan E-K, Van Broeckhoven C on behalf of the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.  "Collaborative Analysis of Alpha-Synuclein Gene Promoter Variability and Parkinson's Disease."  JAMA 2006;296:661-670.
  5. Lipp A, Sandroni P, Ahlskog JE, Maraganore DM, Shults CW, Low PA.  "Calf Venous Compliance in Multiple System Atrophy.”  American Journal of Physiology.  Heart and Circulatory Physiology 2007;293:H260-5.
  6. Frigerio R, Breteler MMB, de Lau LML, Sanft KR, Bower JH, Ahlskog JE, Grossardt BR, de Andrade M, Maraganore DM, Rocca WA.  "Number of Children and Risk of Parkinson's Disease."  Movement Disorders 2007;22:632-639.
  7. Seminara D, Khoury MJ, O'Brien TR, Manolio T, Gwinn ML, Little J, Higgins JPT, Bernstein JL, Bofetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam A, Danesh J, Smith GD, Solan S, Duncan R, Gruis NA, Hashibe M, Hunter D, Jarvelin JR, Malmer B, Maraganore DM, Newton-Bishop JA, Riboli E, Salanti G, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R & Ioannidis JPA for the Human Genome Epidemiology Network and the Network of Investigator Networks.  "The Emergence of Networks in Human Genome Epidemiology: Challenges and Opportunities."  Epidemiology 2007;18:1-8.
  8. Evangelou E, Maraganore DM, Ioannidis JPA.  "Meta-Analysis in Genome-Wide Association Datasets: Strategies and Application in Parkinson Disease."  PLos One 2007;Vol. 2, No. 2: e196.
  9. Rocca WA, Bower JH, Ahlskog JE, Elbaz A, Grossardt BR, McDonnell SK, Schaid DJ, Maraganore DM.  "Increased Risk of Essential Tremor in First-Degree Relatives of Patients with Parkinson's Disease."  Movement Disorders 2007;22:1607-1614.
  10. Arabia G, Grossardt BR, Geda YE, Carlin JM, Bower JH, Ahlskog JE, Maraganore DM, Rocca WA.  "Increased Risk of Depressive and Anxiety Disorders in Relatives of Parkinson's Disease Patients."  Archives of General Psychiatry 2007;64:1385-1392.
  11. Rocca WA, Bower JH, Maraganore DM, Ahlskog JE, Grossardt BR, de Andrade M, Melton LJ 3rd.  "Increased Risk of Cognitive Impairment or Dementia in Women Who Underwent Oophorectomy Before Menopause."  Neurology 2007;69:1074-1083.
  12. Rocca WA, Bower JH, Ahlskog JE, Elbaz A, Grossardt BR, McDonnell SK, Schaid DJ, Maraganore DM.  "Risk of Cognitive Impairment or Dementia in Relatives of Patients with Parkinson Disease."  Archives of Neurology 2007;64:1458-1464.
  13. Lesnick TG, Papapetropoulos S, Mash DC, Ffrench-Mullen J, Shehadeh L, de Andrade M, Henley JR, Rocca WA, Ahlskog JE, Maraganore DM.  "A Genomic Pathway Approach to a Complex Disease:  Axon Guidance and Parkinson's Disease."  PLos Genetics 2007;Vol.3, No. 6; e98 doi:10.1371/journal.pgen.0030098.
  14. Brighina L, Okubadejo NU, Schneider NK, Lesnick TG, de Andrade M, Cunningham JL, Farrer MJ, Lincoln SJ, Rocca WA, Maraganore DM.  "Beta-Synuclein Gene Variants and Parkinson's Disease:  A Preliminary Case-Control Study."  Neuroscience Letters 2007;420:229-234.
  15. Rocca WA, Brandon GR, Geda YE, Gostout BS, Bower JH, Maraganore DM, de Andrade M, Melton LJ.  "Long-Term Risk of Depressive and Anxiety Symptoms After Early Bilateral Oophorectomy."  Menopause 2008; Vol. 15, No. 6; doi:10.1097/gme.0b013e318174f155.
  16. Brighina L, Frigerio R, Schneider NK, Lesnick TG, de Andrade M, Cunningham JM, Farrer MJ, Lincoln SJ, Checkoway H, Rocca WA, Maraganore DM.  "a-Synuclein, Pesticides, and Parkinson Disease:  A Case-Control Study."  Neurology 2008;70:1461-1469.
  17. Rocca WA, Grossardt BR, Maraganore DM.  "The Long-Term Effects of Oophorectomy on Cognitive and Motor Aging are Age-Dependent."  Neurodegenerative Diseases 2008;5:257-260.
  18. Ross OA, Braithwaite AT, Skipper LM, Kachergus J, Hulihan MM, Middleton FA, Nishioka K, Fuchs J, Gasser T, Maraganore DM, Adler CH, Larvor L, Chartier-Harlin M-C, Nilsson C, Langston JW, Gwinn K, Hattori N, Farrer MJ.  "Genomic Investigation of a-Synuclein Multiplication and Parkinsonism."  Annals of Neurology 2008;63:743-750.
  19. Brighina L, Schneider NK, Lesnick TG, de Andrade M, Cunningham JM, Farrer MJ, Lincoln SJ, Mrazek D, Rocca WA, Maraganore DM.  "a-Synuclein, Alcohol Use Disorders and Parkinson Disease: A Case-Control Study."  Parkinsonism and Related Disorders 2009;15:430-434.
  20. Lesnick TG, Sorenson EJ, Ahlskog JE, Henley JR, Shehadeh L, Papapetropoulos S, Maraganore DM.  "Beyond Parkinson Disease: Amyotrophic Lateral Sclerosis and the Axon Guidance Pathway."  PLoS ONE 2007 3(1): e1449.doi:10.1371/journal.pone.0001449.
  21. Rocca WA, Bower JH, Maraganore DM, Ahlskog JE, Grossardt BR, de Andrade M, Melton III LJ.  "Increased Risk of Parkinsonism in Women Who Underwent Oophorectomy before Menopause."  Neurology 2008;70:200-209.
  22. Facheris MF, Schneider NK, Lesnick TG, de Andrade M, Cunningham JM, Rocca WA, Maraganore DM.  "Coffee, Caffeine-Related Genes, and Parkinson’s Disease:  A Case-Control Study."  Movement Disorders 2008;23:2033-2040.
  23. Lewis J, Melrose HL, Bumcrot D, Hope A, Hinkle K, Kent C, Toudjarska I, Charisse K, Braich R, Pandey RK, Heckman M, Maraganore DM, Crook J, Farrer M.  "In Vivo Silencing of Alpha-Synuclein Using Naked siRNA."  Molecular Neurodegeneration 2008;3:19.
  24. Lin L, Lesnick TG, Maraganore DM, Isacson O.  "Axon Guidance and Synaptic Maintenance: Preclinical Markers for Neurodegenerative Disease and Therapeutics."  Trends in Neuroscience 2009;32:142-149.
  25. Rocca WA, Shuster LT, Grossardt BR, Maraganore DM, Gostout BS, Geda YE, Melton LJ 3rd.  "Long-Term Effects of Bilateral Oophorectomy on Brain Aging:  Unanswered Questions from the Mayo Clinic Cohort Study of Oophorectomy and Aging."  Women’s Health 2009;5:39-48.
  26. Savica R, Bower JH, Maraganore DM, Grossardt BR, Rocca WA.  "Bell's Palsy Preceding Parkinson's Disease:  A Case-Control Study."  Movement Disorders 2009;24:1530-1533.
  27. Evangelou E, Maraganore DM, Annesi G, Brighina L, Brice A, Elbaz A, Ferrarese C, Hadjigeorgiou G, Krüger R, Lambert JC, Lesage S, Markopoulou K, Mellick G, Meeus B, Pedersen N, Quattrone A, Van Broeckhoven C, Sharma M, Silburn P, Tan EK, Wirdefeldt K, Ioannidis JPA for the Genetic Epidemiology of Parkinson's Disease (GEOPD) Consortium.  "Non-Replication of Association for Six Polymorphisms from Meta-Analysis of Genome-Wide Association Studies of Parkinson' Disease:  Large-Scale Collaborative Study."  Neuropsychiatric Genetics 2009; DOI 0.1002/ajmg.b.30980.
  28. Frigerio R, Fujishiro H, Maraganore DM, Klos KJ, DelleDonne A, Heckman MG, Crook JE, Josephs KA, Parisi JE, Boeve BF, Dickson DW, Ahlskog JE.  “Is Incidental Lewy Body Disease Related to Parkinson Disease? Comparison of Risk Factor Profiles.”  Archives of Neuroloy (in press).
  29. Savica R, Grossardt BR, Carlin JM, Icen M, Bower JH, Ahlskog JE, Maraganore DM, Steensma DP, Rocca WA.  "Anemia or Low Hemoglobin Levels Preceding Parkinson Disease:  A Case-Control Study."  Neurology 2009 (in press).
  30. Frigerio RF, Fujishiro H, Ahn T-B, Josephs KA, Marganore DM, DelleDonne A, Parisi JE, Klos KJ, Boeve BF, Dickson DW, Ahlskog JE.  "Incidental Lewy Body Disease: Do Some Cases Represent Preclinical Dementia with Lewy Bodies?"  Neurobiology of Aging 2009 (in press).
  31. Lipp A, Sandroni P, Ahlskog JE, Fealey RD, Gehrking TL, Weigand SD, Sletten DM, Gehrking JA, Nickander KK, Winger W, Maraganore DM, Wenning GK, Shults CM, Low PA.  "Prospective Differentiation of Multiple System Atrophy from Parkinson’s Disease, with and without Autonomic Failure."  Archives of Neurology 2009;66:742-750.
  32. Savica R, Carlin JM, Grossardt BR, Bower JH, Ahlskog JE, Maraganore DM, Bharucha AE, Rocca WA.  "Medical Record Documentation of Constipation Preceding Parkinson Disease: A Case-Control Study."  Neurology 2009;73:1752-1758.
  33. Chung SJ, Armasu SM, Biernacka JM, Lesnick TG, Rider DN, Lincoln SJ, Ortolaza AI, Farrer MJ, Cunningham JM, Rocca WA, Maraganore DM.  "Common Variants in PARK Loci and Related Genes and Parkinson's Disease."  Movement Disorders 2009 (submitted).
  34. Fujishiro H, Imamura A, Lin W-L, Uchikado H, Golbe LI, Markopoulou K, Wszolek ZK, Maraganore DM, Gwinn-Hardy K, Farrer M, Dickson, DW.  "Diversity of Non-Lewy Related Pathology in Familial Parkinson Disease Due to SNCA Mutations."  Neuropathology 2009 (submitted).
  35. Bower JH, Grossardt BR, Maraganore DM, Ahlskog JE, Colligan RC, Geda YE, Therneau TM, Rocca WA. "Anxious Personality Predicts an Increase Risk of Parkinson Disease."  Neurology 2009 (submitted).
  36. Kruger R, Sharma M, Riess O, Gasser T, van Broeckhoven C, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JPA, Jasinska-Myga B, Klein C, Lesage S, Lin JJ, Lyunch T, Mellick GD, de Nigris F, Opala, G, Prigione A, Quattrone A, Ross OA, Satake W, Silburn PA, Tan EK, Theuns J, Toda T, Tomiyama H, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM for the Genetic Epidemiology of Parkinson’s disease consortium.  “A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson’s disease.”  Neurobiology of Aging 2009 (in press).
  37. Arabia G, Grossardt BR, Colligan RC, Bower JH, Maraganore DM, Ahlskog JE, Geda YE, Rocca WA. “Novelty seeking and introversion do not predict the long-term risk of Parkinson’s disease: a cohort study.”  Lancet Neurology (submitted 12/16/09).
  38. Uitti RJ, Ahlskog JE, Maraganore DM, Atkinson EJ, Muenter, MD, Cha RH, O'Brien PC. "Levodopa and Survival" (reply to letter). Neurology 1994;44:1771-1772.
    Dewey RB, Maraganore DM. "Lid-Opening Apraxia" (reply to letter from authors). Neurology 1995;45:1789-1790.
  39. Collins SJ, Ahlskog JE, Parisi JE, Maraganore DM. "Progressive Supranuclear Palsy-Neuropathologically Based Diagnostic Clinical Criteria." Journal of Neurology, Neurosurgery, and Psychiatry 1995;59:106 (letter).
  40. Uitti RJ, Ahlskog JE, Maraganore DM. "Does Levodopa Therapy Delay Death in Parkinson's Disease?" Movement Disorders 1996;11:No. 3 (letter).
  41. Uitti RJ, Ahlskog JE, Maraganore DM. "Levodopa Therapy and Survival." Movement Disorders 1996;11:343-344 (letter).
  42. Quinn NP, Maraganore DM. "Parkinsonism Following Electrical Injury to the Hand." Movement Disorders 2000;15:587-588 (letter).
  43. Rocca WA, Maraganore DM, Benedetti MD. "Smoking, Alcohol, and Coffee Consumption Preceding Parkinson's Disease: A Case-Control Study." Neurology 2000;56:984-985.\
  44. Abbruzzese G, Agid Y, Maraganore DM, et al. "An Open Letter to the Committee on the Nobel Prize in Medicine." Parkinsonism and Related Disorders 2001;7:149-155.
  45. Farrer M, Hardy J, Hutton M, Maraganore DM, Tsuboi Y, Wszolek Z. "Identifying Genetic Factors in Parkinson's Disease." JAMA 2002;287:715-716 (letter).
  46. Ahlskog JE, Maraganore DM, Uitti RJ, Uhl GR. "Brain Imaging to Assess the Effects of Dopamine Agonists on Progression of Parkinson's Disease." JAMA 2002;288:311-313 (letter).

Book Chapters:

  1. Maraganore DM, Adler CH, Ahlskog JE. "Epidemiology and Genetics of Parkinson's Disease," in Parkinson's Disease and Movement Disorders, Humana Press, Totowa NJ 2000.

Abstracts:

  1. Grossardt BR, Bower JH, de Andrade M, Maraganore DM, Melton, LJ, Rocca WA.  The Mayo Clinic Cohort Study of Oophorectomy and Aging:  Design and Follow-Up Description.  Neuroepidemiology 2006;26:P1.
  2. Maraganore DM, de Andrade M, Elbaz A, Farrer M, Ioannidis J, Kruger R, Rocca WA, Schneider N, LEsnick T, Aasly J, Ashizawa T, Chartier-Harlin MC, Checkoway H, Ferrarese C, Hadjigeorgiou G, Hattori N, Kawakami H, Lambert JC, Lynch T, Mellick G, Papapetropoulos S, Parsian A, Quattrone A, Riess O, Tan E-K, Van Broeckhoven C.  Collaborative-Pooled Analysis of alpha-Synuclein REP1 Variability and Parkinson's Disease (PD).  Neurology 2006;66:A63.
  3. Rocca WA, Grossardt B, de Andrade M, Bower JH, Maraganore DMVariants in Genes in the Estrogen Synthesis and Responsiveness Pathway and Risk of Parkinson's Disease:  A Case-Control Study in Women.  Neurology 2006;66:A64.
  4. Rocca W, Grossardt B, Ahlskog E, Bower J, de Andrade M, Maraganore DMThe Mayo Clinic Cohort Study of Oophorectomy and Aging:  Results for Dementia and Cognitive Impairment.  Neurology 2006;66:A216.
  5. Frigerio R, Bower J, Ahlskog E, Grossardt B, de Andrade M, Maraganore DM, Rocca WA.  Education, Physically Demanding Occupations, and the Risk of Parkinson's Disease.  Neurology 2006;66:A234.
  6. Maraganore DM, de Andrade M, Elbaz A, Farrer M, Ioannidis J, Kruger R, Rocca WA, Schneider N, LEsnick T, Aasly J, Ashizawa T, Chartier-Harlin MC, Checkoway H, Ferrarese C, Hadjigeorgiou G, Hattori N, Kawakami H, Lambert JC, Lynch T, Mellick G, Papapetropoulos S, Parsian A, Quattrone A, Riess O, Tan E-K, Van Broeckhoven C.  Collaborative-Pooled Analysis of alpha-Synuclein REP1 Variability and Parkinson's Disease (PD). Neurology 2006;66:A330.
  7. Rocca W, Grossardt B, de Andrade M, Bower J, Maraganore DMVariants in Genes in the Estrogen Synthesis and Responsiveness Pathway and Risk of Parkinson's Disease:  A Case-Control Study in Women.  Neurology 2006;66:A331.
  8. Maraganore DM, de Andrade M, Lesnick T, Farrer M, Rocca W.  High-Resolution Whole-Genome Association Study of Age at Onset Modifier Genes and Parkinson's Disease.  Neurology 2006;66:A333.
  9. Brighina L, Okubadego NU, Schneider NK, Lesnick TG, de Andrade M, Cunningham JL, Farrer MJ, Rocca WA, Maraganore DMJoint Effects of Alpha-Synuclein and Beta-Synuclein Genes in Parkinson's Disease.  Neurology 2007,68:A141.
  10. Arabia G, Bower JH, Ahlskog JE, Maraganore DM, Geda YE, Grossardt BR, Carlin JM, Rocca WA.  Increased Risk of Anxiety, Depression, and Other Psychiatric Disorders in Relatives of Patients with Parkinson's Disease:  A Population-Based Cohort Study.  Neurology 2007;68:A022.
  11. Papapetropoulos S, Maraganore DM, Ffrench-Mullen J, McCorquodale D, Adi N, Mash DC.  Multiregional High-Throughput Gene Expression Profiling of Braak Regions in Parkinson's Disease.  Neurology 2007;68:A049.
  12. Brighina L, Schneider NK, Lesnick TG, de Andrade M, Cunningham JM, Farrer MJ, Lincoln SJ, Mrazek D, Rocca WA, Maraganore DMAlcoholism, Alpha-Synuclein, and Parkinson Disease: A Case-Control Study.  Parkinson’s Disease and Related Disorders 2007;2.313:S125.
  13. Arabia G, Grossardt BR, Geda YE, Carlin JM, Bower JH, Ahlskog JE, Maraganore DM, Rocca WA.  Increased Risk of Depressive and Anxiety Disorders in Relatives of Patients with Parkinson’s Disease.  Parkinson’s Disease and Related Disorders 2007;1.172:S52.
  14. Facheris MF, Schneider NK, Lesnick TG, de Andrade M, Kost LJ, Cunningham JM, Rocca WA, Maraganore DMCigarette smoking, CYP2A6 gene variants, and Parkinson’s Disease: A Case-Control Study.  Movement Disorders 2008;23.89:S33.
  15. Claassen DO, Burnett MS, Huston J, Maraganore DMSecondary Parkinsonism and a Distorted Midbrain.  Movement Disorders 2008;23.215:S73.
  16. Kruger R, Sharma M, Riess O, vanBroeckhoven C, Maraganore DM, Aasly J, Annesi G, Bentivoglio AR, Brice A, Elbaz A, Farrer M, Ferrarese C, Ferraris A, Hadjigeorgiou G, Hattori N, Klein C, Lin JJ, Mellick GD, Opala G, Prigione A, Tan EK, Toda T, Valente EM, Wirdefeldt K, Wszolek Z, Gasser T, GEOPD Consortium (Tuebingen, Germany).  Evaluation of the Genetic Contribution of Omi/HtrA2 to Parkinson's Disease in an International Collaborative Study.  Movement Disorders 2009;24(suppl 1):S152.
  17. Savica R, Grossardt BR, Carlin JM, Bower JH, Ahlskog JE, Maraganore DM, Rocca WA.  Reduced Bowel Movements Preceding Parkinson's Disease: A Case-Control Study.  Movement Disorders 2009;24(suppl 1):S325.
  18. Lipp A, Paola S, Eric A, Fealey RD, Gehrking TL, Weigand SD, Sletten DM, Gehrking JA, Nickander KK, Singer W, Maraganore DM, Wenning GK, Shults CM, Low PA.  Prospective Differentiation of Multiple System Atrophy from Parkinson's Disease.  Movement Disorders 2009;24(suppl 1):S410.
  19. Arabia G, Grossardt BR, Colligan RC, Bower JH, Maraganore DM, Ahlskog JE, Rocca WA.  Novelty Seeking Personality Traits Do Not Influence the Risk of Parkinson's Disease.  Movement Disorders 2009;24(suppl 1):S233.
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