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Home » Research Institute » Investigators » Matthew Derrick, MD

Matthew Derrick , MD

Attending Physician
Pediatrics

Contact Information

 847.570 2920
 847.570 0231 Fax
mailto:mderrick@northshore.org

Education

  • Undergraduate: 1980-83 Robinson College, Cambridge University, England, BA Hons Genetics, MA Cantab.
  • Medical School: 1984-89 The London Hospital Medical College,  London University,Whitechapel,   London, E1,  England. MBBS (June 1989)
  • Pediatric Residency: 1991-1994 Children's Memorial Hospital,  Northwestern University,  Chicago,  IL 60614, USA.
  • Neonatology Fellowship: 1995-1998 CVRI, UCSF, San Francisco, CA 94043,USA

Board Certification

  • The American Board of Pediatrics No. 053104  Oct 12, 1994 Recertification Sept 28 2001
  • The American Board of Pediatrics subboard Neonatal-Perinatal Medicine No. 003460  Nov 15, 1999 Recertification Dec 12, 2006

Research and Academic Interests

My basic science research has been into ameliorating brain injury in the premature infant with the hope that understanding the pathways of injury can be translated into future treatments for human infants. As an academic neonatologist I have expanded my research interests to include clinical research into the patent ductus arterious and respiratory distress syndrome, as the principle investigator at Northshore for multicenter trials. I am also the principle investigator at Northshore in collaboration with Jennfer Batza on several studies that are investigating the counseling of the families at periviable gestations. My plan is to combine the basic science with clinical research to prevent and treat perinatal brain injury. My overall career goal is to contribute to improving outcomes for human infants and their families.

Career Summary

  • Jul 98-Jun 99  Clinical Instructor, Department of Pediatrics, UCSF, San Francisco, CA, 94143, USA.
  • Jul 99- Jul 09  Assistant Professor,  Dept of Pediatrics, Northwestern University, Evanston, IL.
  • Jul 2009         Clinical Assistant Professor, University of Chicago. Chicago IL
  • Jul 1999         Transfusion Committee
  • Jul 2001         Perinatal Morbidity and Mortality Committee
  • Jan 2011        Northshore University Healthsystem IUCAC

Professional Memberships/Affiliations/Activities

  • Fellow of the American Academy of Pediatrics

Scholarly Work

Publications in Peer-Review Journals:

  1. O'Donald P., Derrick M., Majerus M, Weir J. Population Genetic Theory of Assortive Mating, Sexual Selection & Natural Selection of the Two Spot Ladybird,  Adalia Bipunctata. Heredity, 1984 52(1) 433-461
  2. Collins J, Derrick M, Hilder L, Kempley S. Relationship of Maternal Ethnicity to Infant Birthweight in East London, England. Ethnicity & Disease, 1997 7 1-4.
  3. Hawgood S, Derrick M, Poulain F. Structure and Function of Surfactant Protein B. Biochimica et Biophysica Acta 1408 (1998) 150-160.
  4. Tan S, Bose R, Derrick M. Hypoxia-ischemia in fetal rabbit brain increases reactive nitrogen species production: quantitative estimation of nitrotyrosine. (2001) Free Radical Biol Med 30(9) 1045-1051
  5. Brasch F, Ochs M, Kahne T,Guttentag S, Schauer-Vukasinovic V, Derrick M, Johnen G, Kapp N, Muller K M, Richter J. Giller T, Hawgood S, Buhling F. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. (2003) J Biol Chem 278(49) 49006-14
  6. Derrick M, Back, S, Ji X, Fisher K, Bregman J, Jilling T, Tan S. Preterm fetal hypoxia-ischemia causes hypertonia and motor deficits in the neonatal rabbit: A model for human cerebral palsy? (2004) J of Neuroscience 24(1) 24-34
  7. Drobyshevsky A, Song S, Gamkrelidz G, Wyrwicz AM, Derrick M, Meng F, Li L, Ji X, Trommer, B, Beardsley DJ, Luo NL, Back SA, Tan S. Developmental changes in diffusion anisotropy coincides with immature oligodendrocyte progression and maturation of compound action potential. (2005) J. Neurosci. 25(25) 5988-97
  8. Tan S, MD; Drobyshevsky A, Jilling T, Ji X, Ullman LM, Englof I, Derrick M.  Model of Cerebral Palsy in the Perinatal Rabbit. (2005) J Child Neurol 20(12) 972-9 Derrick, M.; Drobyshevsky, A.; Ji, X.; Tan, S. A model of cerebral palsy from fetal hypoxia-ischemia (2007) Stroke 38(2) 731-5
  9. Drobyshevsky, A.; Derrick, M.; Wyrwicz, A. M.; Ji, X.; Englof, I.; Ullman, L. M.; Zelaya, M. E.; Northington, F. J.; Tan, S. White matter injury correlates with hypertonia in an animal model of cerebral palsy. (2007) J Cereb Blood Flow Metab 27(2) 270-81
  10. Drobyshevsky A, Derrick M, Prasad P.V, Ji X, Englof I, Tan S. Fetal Brain MRI Response Acutely to Hypoxia-Ischemia Predicts Postnatal Outcome. Annals of Neurology, 2007, 61(4):307-314.
  11. Drobyshevsky A, Bregman J, Storey P, Meyer J, Prasad P.V, Derrick M, Mackendrick W, Tan S. Serial Diffusion Tensor Imaging Detects White Matter Changes That Correlate With Motor Outcome In Premature Infants. Dev Neurosci, 2007;29:289–301.
  12. Ji, H.; Tan, S.; Igarashi, J.; Li, H.; Derrick, M.; Martasek, P.; Roman, L. J.; Vasquez-Vivar, J.; Poulos, T. L.; Silverman, R. B. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Annals of Neurology 2009 65(2): 209-17
  13. Vásquez-Vivar, J., Whitsett, J., Derrick, M., Ji, X., Yu, L., Tan, S. Tetrahydrobiopterin in the Prevention of Hypertonia in Hypoxic Fetal Brain Annals of Neurology 66(3) 323-31 2009
  14. Derrick, M.; Drobyshevsky, A.; Ji, X.; Chen, L.; Yang, Y.; Ji, H.; Silverman, R. B.; Tan, S.Hypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test. Int J Dev Neurosci  27(6) 549-57 2009
  15. Buser, J. R, Segovia K.N, Dean, J. M.  Nelson, K.  Beardsley, D.  Gong, X.  Luo, N. L.  Ren, J.  Wan, Y.  Riddle, A.  McClure, M. M.  Ji, X, Derrick, M., Hohimer, AR., Back SA and S. Tan Timing of appearance of late oligodendrocyte progenitors coincides with enhanced susceptibility of preterm rabbit cerebral white matter to hypoxia-ischemia.  J Cereb Blood Flow Metab. 30(5) 1053-65
  16. Rao S. Lin Z, Drobyshevsky A, Chen L, Ji X, Ji H, Yang Y, Yu L, Derrick M, Silverman RB, Tan S. Involvement of Neuronal Nitric Oxide Synthase in Ongoing Fetal Brain Injury Following Near-Term Rabbit Hypoxia-Ischemia. Dev Neurosci, 2011. 33(3-4): p. 288-98.
  17. Yu, L. Derrick, M. Ji, H. Silverman, R. B. Whitsett, J. Vasquez-Vivar, J. Tan, S.Neuronal Nitric Oxide Synthase Inhibition Prevents Cerebral Palsy following Hypoxia-Ischemia in Fetal Rabbits: Comparison between JI-8 and 7-Nitroindazole. Dev Neurosci, 2011. 33(3-4): p. 312-9.
  18. N. J. Robertson, S. Tan, F. Groenendaal, F. van Bel, S. E. Juul, L. Bennet, M. Derrick, S. A. Back, R. C. Valdez, F. Northington, A. J. Gunn and C. Mallard. Which Neuroprotective Agents are Ready for Bench to Bedside Translation in the Newborn Infant? J Pediatr. 2012 Feb 8
  19. L. Bennet, S. Tan, L. Van den Heuij, M. Derrick, F. Groenendaal, F. van Bel, S. Juul, S. A. Back, F. Northington, N. J. Robertson, C. Mallard and A. J. Gunn. Cell therapy for neonatal hypoxia-ischemia and cerebral palsy. Ann Neurol. 2012 May;71(5):589-600.
  20. A. Drobyshevsky, K. Luo, M. Derrick, L. Yu, H. Du, P. V. Prasad, J. Vasquez-Vivar, I. Batinic-Haberle and S. Tan. Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants. J Neurosci. 2012 Apr 18;32(16):5500-9.
  21. M. Derrick, I. Englof, A. Drobyshevsky, K. Luo, L. Yu and S. Tan. Intrauterine fetal demise can be remote from the inciting insult in an animal model of hypoxia-ischemia. Pediatr Res. 2012 May 11.
  22. A. Drobyshevsky, M. Derrick, K. Luo, L. Zhang, Y. Wu,, L. Yu, S. Tan, Near-Term Fetal Hypoxia-Ischemia in rabbits: MRI can predict muscle tone abnomalities and deep brain injury. Stroke 43(10): 2757-2763.
  23. A. Drobyshevsky, L. Yu, Y. Yang, S.  Khalid, K. Luo, R. Jiang, H. Ji, M. Derrick, L. Kay, R.B. Silverman, S. Tan. Antenatal Insults Modify Newborn Olfactory Function By Nitric Oxide Produced From Neuronal Nitric Oxide Synthase. Exp Neurol 237(2): 427-434.
  24. R. Clyman, A. Wickremasinghe, N. Jhaveri, D. C. Hassinger, J. T. Attridge, U. Sanocka, R. Polin, M. Gillam-Krakauer, J. Reese, M. Mammel, R. Couser, N. Mulrooney, T. D. Yanowitz, M. Derrick, P. Jegatheesan, M. Walsh, A. Fujii, N. Porta, W. A. Carey and J. R. Swanson. Enteral Feeding during Indomethacin and Ibuprofen Treatment of a Patent Ductus Arteriosus. J Pediatr. 2013 Mar 5 Epub Date: 2013/03/12.
  25. L. Yu, J. Vasquez-Vivar, R. Jiang, K. Luo, M. Derrick, S. Tan. Developmental susceptibility of neurons to transient tetrahydrobiopterin insufficiency and antenatal hypoxia-ischemia in fetal rabbits. Free Radic Biol Med 2014 67 426-36Epub Date: 2013/12/10.
  26. A. Drobyshevsky, R. Jiang, L. Lin, M. Derrick, K. Luo, S. A. Back and S. Tan. : Unmyelinated axon loss with postnatal hypertonia after fetal hypoxia. Ann Neurol 2014 Feb 6. Epub Date: 2014/03/19

Book Chapters:

  1. Reactive mitrogen and oxygen species in perinatal hypoxia-ischemia. Matthew Derrick and Sidhartha Tan.  Mechanisms of Hypoxic brain injury in the newborn and potential stratagies for Neuroprotection 2007.

Journal Reviewer for:

  • Brain Research
  • Developmental Neuroscience
  • Free Radical Biology and Medicine
  • Journal of Neuroscience
  • Journal of Neurochemistry
  • Neurochemical research
  • Pediatric Research
  • Journal of Neurotrauma

Abstracts:

  1. Derrick M, Brinien L, Hawgood S. Heterologous expression and in vitro folding of the human Surfactant protein B recursor. Pediatric Res 43(4) A1642 1998
  2. Solano JP.,  Derrick, M., Sola A.:Inhaled Frusomide does not improve pulmonary function tests in infants with chronic lung disease on mechanical ventilation. Journal on Investigative Medicine 1998 46:1 (Abs)
  3. Bose R, Jilling T, Caplan M, Derrick M, Tan S. Electrochemical Detection Of Nitrotyrosine In Fetal Brains Following Repetitive Uterine Ischemia. Free Radic Biol Med 27 (supplement 1):S73, 1999
  4. Brasch F, Ochs M, Derrick M, Johnen G, Wahlers T, Muller KM, Hawgood S, Richter J. Immunolocalisation of ProSP-B and SP-B in the human Lung. Amer. Jour Resp & Critical Care Medicine 161 (3) A44 2000
  5. Derrick M, Brady E, He J, Bose R, Kallio P, Tan S. Flow cytometric analysis of in vitro fate of rabbit fetal brain cells following acute in vivo hypoxia. Pediatr Res 47(4):396A, 2000.
  6. Derrick M, He J, Brady E, Bose R, Griffith OW, Babu RB, Tan S. In situ fetal rabbit brain cell viability with nitric oxide synthase inhibition following acute in vivo hypoxia-reoxygenation. Pediatr Res 47(4):457A, 2000.
  7. Tan S, Jilling T, Derrick M, He J, Brady E, Bose R, Bregman J.  Effect of antenatal hypoxia-reoxygenation on neurobehavioral assessment of newborn rabbits. Pediatr Res 47(4):435A, 2000.
  8. Tan S, Bose R, He J, Brady E, Babu R, Griffith OW. Derrick M, Nitric Oxide-Derived Reactive Species Increases In Fetal Rabbit Brain Following Hypoxia-Reoxygenation. Pediatr Res 47(4):466A, 2000
  9. Tan S, Pouremad R, Wyrwicz A, He J, Brady E, Derrick M, Luo NL, Back SA. White matter injury in fetal rabbits after in utero hypoxia-ischemia results in death of oligodendrocyte precursors. Soc. Neurosci. Abstr., Vol 26, Part 2, p 2065, 2000.
  10. Tan S, Derrick M, He J, Brady E, Qu X-W, Wei H, Babu BR, Griffith OW. Neuronal NOS inhibition decreases reactive nitrogen species-mediated injury in fetal rabbit brain following hypoxia. Free Radic Biol Med 29 Supplement 1:S77, 2000.
  11. Brasch F, Johnen G, Derrick M, Schauer-Vukasinovic V, Ochs M, Muller K, Richter J, Giller T, Hawggod S, Buhling F.  Cathepsin H and Napsin A are involved in the processing of proSP-B.  ATS 2001.
  12. Derrick M, Brady E, He J, Tan S. Fetal Rabbit Cortical Neuronal Injury Following Acute Repetitive In Utero Hypoxia-Reoxygenation. Pediatr Res 49(4) 352A, 2001.
  13. Derrick M, He J, Brady E, Bregman J, Tan S. A Cerebral Palsy Phenotype in Newborn Rabbits Following Antenatal Hypoxia-Ischemia to Preterm Fetuses. Pediatr Res 49(4) 432A, 2001.
  14. Tan S, Venkatasubramanian PN, Derrick M, Tom B, Wyrwicz AM, He J, Brady E, Luo NL, Back SA. In Utero Hypoxia-Ischemia Results in White Matter Injury and Death of Oligodendrocyte Precursors in Fetal Rabbits. Pediatr Res 49(4) 446A, 2001.
  15. TanS. Derrick M, Jilling T, Brady E, Chen J, Parks DA. Fetal Neuronal injury in near-term rabbits following xanthine inhibition and repetitive hypoxia-ischemia. Soc. Neurosci. Abstr., Vol. 27, Program No. 572.14, 2001.
  16. Derrick M, Ji X, Fisher KM, Chen J, Crow JP, Tan S. In vitro rescue of fetal rabbit brain cells by antioxidants after in vivo hypoxic-ischemic insults. Pediatr Res 51(4) 364A, 2002.
  17. Huynh N, Liu X, Goss D, Derrick M, Tan S. Preterm hypoxia-ischemia to rabbit fetusesincreases neuronal nitric oxide synthase expression. Pediatr Res 51(4) 446A, 2002.
  18. Derrick M, Ji X, Huynh N, Fisher KM, Chen J, Tan S. In vitro assessment of fetal rabbit brain cell mitochondrial function after in vivo hypoxic-ischemic insults. Pediatr Res 51(4) 446A, 2002.
  19. Derrick M, Ji X, Huynh N, Fisher KM, Chen J, Tan S.. Intrauterine fetal brain and body growth following a single episode of placental insufficiency in the preterm rabbit. Pediatr Res 51(4) 465A, 2002.
  20. M. Derrick, X. Ji, K. Fisher, J.- Bregman, T. Jilling, S. Tan. Antenatal Hypoxia-ischemia in pretem fetuses results in a cerebral palsy phenotype and perinatal deaths in newborn rabbits. Program No. 488.4. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002.
  21. S. Tan, N.- Huynh, K. Fisher, X. Ji, J.P. Crow, M. Derrick. Role of neuronal nitric oxide synthase and reactive nitrogen species in brain injury following fetal rabbit hypoxia-ischemia. Program No. 488.5. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online
  22. Fisher K, Derrick M, Ji X, Shah N, Silverman RB, Hah JM, Tan S. In vitro fate of fetal brains cells with treatment of Rick1, a new neuronal nitric oxide synthase inhibitor, following in vivo hypoxia-ischemia. Society for Pediatric Research 2003 on line
  23. Derrick M, Fisher K, Ji X, Shah N, Tan S. The effect of Platelet activating factor on the fate of primary dissociated fetal brain cells. Society for Pediatric Research 2003 on line.
  24. Derrick M, Ji X, Fisher K, Tan S. Role of reactive oxygen species in continuing injury of brain cells from fetal rabbits following in vivo hypoxia/ischemia. Program Number: 530.9 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. Online
  25. Tan S, Derrick M, Luo NL, Bregman JC, Jilling T, Ji X, Fisher K, Gladson CL, Murdoch G, Back S. Activated microglial reaction and hypertonia at birth in a cerebral palsy model involving preterm hypoxia-ischemia. Program Number: 40.9 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. Online
  26. Derrick M, Ji X, Ullman LM, Kotlajich MV, Shah N, Tan S. Platelet activating factor acetyl hydrolase (LIS-1) and the developing brain, changes with hypoxia-ischemia. Society for Pediatric Research 2004 on line
  27. Drobyshevsky A, Back SA, Wyrwicz AM, Derrick M, Li L, Ji X, Kotlajich MV, Tan S. Diffusion tensor imaging of the developing rabbit brain. Society for Pediatric Research 2004 on line.
  28. Derrick M, Ji X, Ullman L.M, Kotlajich MV, Tan S. Platelet activating factor(PAF) and PAF-acetyl hydrolase(LIS-1) in the developing rabbit brain.Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online
  29. Drobyshevsky A, Back SA, Wyrwicz AM, Derrick M, Li L, Ji X, Kotlajich MV, Tan S. White matter development in the perinatal rabbit brain by MRI and electrophysiology. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online
  30. Drobyshevsky A, Derrick M, Ullman LM, Englof I, Ji X, Wyrwicz AM, Tan S. White Matter Injury Correlates with Hypertonia in a Cerebral Palsy Model. Society for Pediatric Research 2005 on line
  31. Tan S, Drobyshevsky A, Jilling T, Ji X, Ullman LM, Englof I, Derrick M. Hypertonia Persists in a Model of Cerebral Palsy in the Perinatal Rabbit. Society for Pediatric Research 2005 on line
  32. M. Derrick, A. Drobyshevsky, I. Englof, X. Ji, L.M. Ullman, S. Tan. A Modified forced swim test to Quantify Persistent deficits in a perinatal rabbit model of cerebral palsy.  Program No. 603.17. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online
  33. A. Drobyshevsky, M. Derrick, A.M. Wyrwicz, X. Ji, L. Ullman, I. Englof, S. Tan. White Matter Injury Correlates with Hypertonia in a Cerebral Palsy Model. Program No. 222.12. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online
  34. A Drobyshevsky, M Derrick, AM. Wyrwicz, X. Ji, I. Englof, ME. Zelaya, FJ. Northington, S. Tan  The Predictive Value of MRI Indices of White Matter Injury for Hypertonia in a Cerebral Palsy Model.  Society for Pediatric Research 2006 on line
  35. A. Drobyshevsky, AM. Robinson, M.Derrick, AM. Wyrwicz, X. Ji, I. Englof, S. Tan .Novel Application of MEMRI Detects Sensory Deficits from Olfactory System Injury in Newborn Rabbit After Antenatal Hypoxia-Ischemia.  Society for Pediatric Research 2006 on line
  36. M. Derrick, A.Drobyshevsky,  X. Ji, I. Englof, S. Tan. Mild Motor Dysfunction and severe deficits persist as shown by joint movement quantification, in a perinatal rabbit model of Cerebral Palsy.Society for Pediatric Research 2006 on line
  37. Suma Rao, Zhenlang Lin, Xinhai Ji, Nina Sahay, Alexander Drobyshevsky, Lei Yu, Richard Silverman, Matthew Derrick, Sidhartha Tan. Inhibition of Neuronal Nitric Oxide Synthase in Fetal Rabbit Brain Slices after In Vivo Injury Is Protective. Society for Pediatric Research 2007 on line
  38. Matthew Derrick, Richard B. Silverman, Haitao Ji, Nina Sahay, Zhenlang Lin, Xinhai Ji, Sidhartha Tan.Administration of Novel nNOS Inhibitor, JI-8 Prevents Fetal Rabbits from Exhibiting a Cerebral Palsy Phenotype. Society for Pediatric Research 2007 on line
  39. Alexander Drobyshevsky, Matthew Derrick, Alice M. Wyrwicz, P.V. Prasad, Xinhai Ji, Nina Sahay, Sidhartha Tan. Diffusion-Weighted Imaging Predicts Cerebral Palsy Phenotype after Fetal Hypoxia-Ischemia in Rabbits. Society for Pediatric Research 2007 on line
  40. Zhenlang Lin, Emily Obringer, Nina Sahay, Xinhai Ji, Sidhartha Tan, Matthew Derrick. Male and Female Rabbit Fetuses Showed No Differences in Brain Cell Injury after Fetal Hypoxia-Ischemia  Society for Pediatric Research 2007 on line
  41. A. Drobyshevsky, J. Vasquez-Vivar, L. Yu, N. Sahay, Z. Lin, X. Ji, M. Derrick, S. Tan. Can oxidative stress explain the acute changes on MRI that are directly linked to eventual motor phenotype of cerebral palsy.  Society for Neuroscience, 2007. Online
  42. M. Derrick, J.Whitsett, L. Yu, X. Ji, S.Tan, J.Vasquez-Vivar. Supplementation of Tetrahydrobiopterin in a Cerebral Palsy Model in Rabbits Society for Pediatric Research 2008 on line
  43. Lei Yu, Xinhai Ji, Alexander Drobyshevsky, Matthew Derrick, Tamas Jilling, Sidhartha Tan. Molecular Cloning of Rabbit Xanthine Oxidase and the Developmental Modulation of Its Expression in Fetal Brain. Society for Pediatric Research 2008 on line
  44. Kerst J. Nelson, Kristen N. Segovia, Melissa McClure, Matthew Derrick, Sidhartha Tan, Stephen A. Back. The Magnitude of Fetal Rabbit Cerebral White Matter Injury from Hypoxia-Ischemia Coincides with the Timing of Appearance of Late Oligodendrocyte (OL) Progenitors. Society for Pediatric Research 2008 on line
  45. Alexander Drobyshevsky, Matthew Derrick, Xinhai Ji, Lei Yu, Sidhartha Tan. Novel Application of Manganese-Enhanced MRI Shows That Basal Ganglia Behave Differently in Hypertonic Newborn Rabbits After Antenatal Hypoxia-Ischemia. Society for Pediatric Research 2008 on line.
  46. Lei Yu, Alexander Drobyshevsky, Xinhai Ji, Matthew Derrick, Sidhartha Tan. [506] Neuronal Nitric Oxide Synthase Level Is a Critical Determinant of Neuronal Survival Society for Pediatric Research 2008 on line.
  47. Jeannette Vasquez-Vivar, Jennifer Whitsett, Xinhai Ji, Lei Yu, Matthew Derrick, Sidhartha Tan. Neuroprotective actions of tetrahydropterin against hypoxia-induced motor impairments in the fetal brain. Sixth Hershey Conference on Developmental Brain Injury.
  48. Lei Yu, Alexander Drobyshevsky, Xinhai Ji, Matthew Derrick. The level of Neuronal Nitric Oxide Synthase is a critical determinant of neuronal death following fetal hypoxia-ischemia. Sixth Hershey Conference on Developmental Brain Injury.
  49. Lei Yu, Xinhai Ji, Alexander Drobyshevsky, Matthew Derrick, Tamas Jilling, Sidhartha Tan. Molecular Cloning of rabbit xanthine oxidase and the developmental modulation of its expression in fetal brain. Sixth Hershey Conference on Developmental Brain Injury.
  50. L. YU, X. JI, A. DROBYSHEVSKY, M. DERRICK, S. TAN. Molecular cloning of rabbit xanthine dehydrogenase elucidates the developmental pattern of expression in perinatal brain and response to hypoxia-ischemia. Society for Neuroscience, 2008. Online
  51. M. DERRICK, L. YU, A. DROBYSHEVSKY, X. JI, S. TAN Neuronal nitric oxide synthase level is a critical determinant of neuronal death following fetal hypoxia-ischemia Society for Neuroscience, 2008 Online
  52. Xinhai Ji, Elisabeth Tracy, Alexander Drobyshevsky, Matthew Derrick, Lei Yu, Aiping Liu, Michael Cotten, Ronald N. Goldberg, Joanne Kertzberg, Sidhartha Tan. Do Human Umbilical Cord Blood Cells Improve Outcome in a Fetal Rabbit Model of Cerebral Palsy. 2009 Abstract Viewer/Itinerary Planner. PAS, SPR meeting at Baltimore, MD. May 3, 2009. Poster Symposium
  53. Lei Yu, Xinhai Ji, Matthew Derrick, Sidhartha Tan, Alexander Drobyshevsky. Response of the In Vivo Rabbit Newborn Olfactory System to a Nitric Oxide Stimulus. 2009 Abstract Viewer/Itinerary Planner. PAS, SPR meeting at Baltimore, MD. May 3, 2009. Poster
  54. Alexander Drobyshevsky, Laixiang Lin, Matthew Derrick, Xinhai Ji, Lei Yu, Sidhartha Tan. Structure Function Relationships of White Matter Tracts by MRI and Electrophysiology in a Rabbit Model of Cerebral Palsy. 2009 Abstract Viewer/Itinerary Planner. PAS, SPR meeting at Baltimore, MD. May 3, 2009. Poster
  55. Matthew Derrick, Alexander Drobyshevsky, Xinhai Ji, Lina Chen, Yiro Yang, Sidhartha Tan. Joint Motion Analysis during Supported Swimming Detects Differences in Non-Hypertonic Hypoxia-Ischemic Rabbits and Changes with a Very Selective nNOS Inhibitor. 2009 Abstract Viewer/Itinerary Planner. PAS, SPR meeting at Baltimore, MD. May 3, 2009. Poster
  56. L. Yu1, A. Drobyshevsky, X. Ji, M. Derrick, S. Tan.  NEURONAL NITRIC OXIDE SYNTHASE LEVEL IS A CRITICAL DETERMINANT OF NEURONAL DEATH FOLLOWING FETAL HYPOXIA-ISCHEMIA. The XXIVth International Symposium on Cerebral Blood Flow and Metabolism & The IXth International Conference on Quantification of Brain Function with PET Chicago, IL, USA - June 29th -July 3rd, 2009
  57. A. Drobyshevsky, M. Derrick, X. Ji, L. Yu, S. Tan. REGIONAL PATTERN AND TIME COURSE OF INJURY IN NEAR TERM RABBIT FETAL HYPOXIA-ISCHEMIA. The XXIVth International Symposium on Cerebral Blood Flow and Metabolism & The IXth International Conference on Quantification of Brain Function with PET Chicago, IL, USA - June 29th -July 3rd, 2009
  58. M. Derrick, A. Drobyshevsky, X. Ji, Y. Yang, R. Silverman, H. Ji, S. Tan. A NEW SWIM TEST QUANTIFIES MOVEMENT DEFICITS IN PERINATAL RABBITS AFTER FETAL HYPOXIA-ISCHEMIA. The XXIVth International Symposium on Cerebral Blood Flow and Metabolism & The IXth International Conference on Quantification of Brain Function with PET Chicago, IL, USA - June 29th -July 3rd, 2009
  59. X. Ji,, M. Derrick, L. Yu, A. Drobyshevsky, A. Liu, S. Tan. CEREBRAL PALSY PHENOTYPE IN RABBITS MODELING PROGRESSION FROM PARTIAL TO COMPLETE PLACENTAL INSUFFICIENCY. The XXIVth International Symposium on Cerebral Blood Flow and Metabolism & The IXth International Conference on Quantification of Brain Function with PET Chicago, IL, USA - June 29th -July 3rd, 2009
  60. Xinhai Ji, Alexendra Drobyshevsky, Haitao Ji, Matthew Derrick, Lei Yu, Aiping Liu, Richard B. Silverman, Sidhartha Tan. Therapeutic Application of a New Selective Neuronal Nitric Oxide Synthase Inhibitor in a Refined Cerebral Palsy Rabbit Phenotype Modeling Progression from Partial to Complete Placental Insufficiency. 2010 Abstract Viewer/Itinerary Planner. PAS, SPR meeting at Vancouver CA. May , 2010
  61. Lei Yu,  Xinhai Ji,  Aiping Liu, Alexander Drobyshevsky,  Ronna Dornsife, Matthew Derrick, Yirong Yang, Michael Cotten,  Ronald Goldberg, Joanne Kurtzberg, and Sidhartha Tan. Determining a Safe and Effective Dose of Human Umbilical Cord Blood cells in The Fetal Rabbit Model of Cerebral Palsy. Seventh Hershey Conference on Developmental Brain Injury Snowbird, June 3-5, 2010
  62. Lei Yu, Kate Zappia, Matthew Derrick, Benjamin Carney, Xinhai Ji, Jennifer Whitsett, Sidhartha Tan. The Vital Role Of Tetrahydrobiopterin In The Survival Of Neurons In Different Regions Of The Fetal Brain. Seventh Hershey Conference on Developmental Brain Injury Snowbird, June 3-5, 2010
  63. Alexander Drobyshevsky, Xinhai Ji, Yirong Yang, Matthew Derrick, Lei Yu, Sidhartha Tan. Decreased Functional Connectivity in Postnatal Rabbit Kits with Motor Deficits Following Antenatal Hypoxia-Ischemia . Seventh Hershey Conference on Developmental Brain Injury Snowbird, June 3-5, 2010
  64. M. Derrick, J. Kondapalli,P.T. Schumacker.Hypothermia and Decreased Hypoxia during Reperfusion Decrease Cell Death during Simulated Ischemia-Reperfusion, abstract #754399, 2011 PAS April 30-May 3, 2011, in Denver, Colorado.
  65. M. Derrick, Joanne Bregman,W. MacKendrick. Are 23 Week Infants Different from 24 and 25 Week Infants?, abstract #754295 PAS 2011, April 30-May 3, 2011, in Denver, Colorado
  66. L. Yu, A. Drobyshevsky, K. Luo, R. Jiang, M. Derrick, S.Tan. Reperfusion Injury Reduced Oligodendrocytes Number in Rabbit Fetal Brain after in Uterus Hypoxia Ischemia [1526.450] PAS Boston 2012
  67. L. Yu, M. Derrick, K. Luo, R. Jiang, A. Drobyshevsky, S. Tan.  Futility Design and Therapies Targeting Critical Oxidative Stress for Preventing Motor Deficits in an Animal Model [4501.26] PAS Boston 2012
  68. K. Luo, L.Yu, A.Shah, R.Jiang, A.Drobyshevsky, M. Derrick, S. Tan.A New Chorioamnionitis Model in Rabbits Produces Neurobehavioral Deficits  [1540.574] PAS 2013 Washington DC May 4 2013
  69. J. Batza, A. Janvier, M. Derrick. He Said She Said: Perceived vs Actual Concerns of Prospective Parents with Threatened Preterm Delivery at the Margin of Viability [2909.88] PAS 2013 Washington DC May 5, 2013
  70. A. Drobyshevsky, R. Jiang, L. Lin, L. Yu, M. Derrick, K. Luo, S.A. Back, S. Tan. Postnatal Hypertonia Caused by White Matter Injury in Unmyelinated Fiber Tracts Following Antenatal Hypoxia-Ischemia. PAS 2013 Washington DC May 7, 2013

Grants:

  • PI. Research Training Fellowship 7/97-6/98
  • American Lung Association of California. $20,000
  • PI Research Training Fellowship 7/98-6/99 American Lung Association. $35,000
  • Principle Investigator.Pilot Grant Program 6/04-5/05
  • ENH Research Institute. The role of Platelet Activating Factor and PAF Acetyl Hydrolase in developing Brain.$29,750
  • Co- Inv R-21 NS41476 Back (PI), Derrick (Co-I) 8/1/01-7/31/04
  • NINDS  Cellular Mechanisms of Preterm White Matter Injury
  • Co-Inv R01-NS043285-01A1 Tan (PI), Derrick (Co-I)  12/1/2002-11/30/2007
  • NINDS/NICHD  Reactive Nitrogen Species in Hypoxic Brain Injury
  • Co-Inv R01 NS051402 Tan (PI), Derrick (Co-I) 07/1/06-06/30/11
  • NINDS Perinatal White Matter Development and Fetal Hypoxia
  • Co-Inv R21 R21HD054742-01 Tan (PI) 09/20/07-09/19/09
  • NICHD Redox Modulation of Nitric Oxide in Olfactory Dysfunction after Fetal Hypoxia
  • Co-Inv 2R56NS043285-06A2 Tan (PI) 8/09/10-09/08/11
  • NINDS  Neuronal nitric oxide synthase in early critical fetal brain injury from hypoxia
  • PI K08- HD057307-01A1 9/1/2008- 8/31-2013
  • NICHD Mitochondria, Superoxide & MnSOD in a fetal hypoxic cerebral palsy model

Publications

View more results at PubMed.gov