Our genes tell a lot about our chances of inheriting various diseases and conditions, including cancer, heart disease, neurological disorders and others. Couple this with a complete family medical history, and we can learn even more about our susceptibility and risk of developing a multitude of health conditions.
By having a thorough medical perspective, both personally and familial, our Medical Genetics experts can provide our patients with:
- Risk assessments based on personal and family health history
- Genetic testing, if desired
- Genetic counseling and guidance around disease management, screening and prevention
Through genetic testing and analysis, our team at the Center for Personalized Medicine can help you better prevent, screen and treat many different health concerns, including:
Not all instances of cancer are hereditary, many factors including lifestyle, environmental exposures and diet also come into play. In fact, most cancers—between 85-90%—are not inherited. The best way to know your genetic susceptibility is through genetic counseling, and then genetic testing, if applicable. The following cancers may have a more prominent familial tendency, caused by a single gene mutation:
- Breast and ovarian cancer—BRCA1 and BRCA2 gene mutations
- Colorectal cancer—APC gene mutation
- Lynch syndrome
- Endometrial cancer
All cancers have molecular abnormalities, thus making them potentially treatable by personalized, targeted therapies. As our research continues to evolve, we hope to continue to identify the genetic mutations and improve care and treatment outcomes.
Some neurological conditions, including some forms of degeneration and dementia, do have a known genetic mutation that can increase your likelihood of developing that disease. The following conditions, in either your personal or family history, may mean a genetic consultation would be appropriate to learn more about your risk:
- Alzheimer’s disease
- Parkinson’s disease
- History of strokes
- Seizure disorder
Through research being done at our NorthShore Neurological Institute with the DodoNA project, our team is identifying genomic patterns to help predict neurological outcomes for many neurological conditions.
Many cardiovascular conditions can be prevented through early diagnosis and treatment if it’s suspected they may be hereditary. Some of the most common hereditary heart conditions include:
- Cardiomyopathies (dilated, hypertrophic and arrhythmogenic cardiomyopathies)
- Cardiac conduction defects
- Alterations in lipids, such as cholestrerol, leading to increased risk of coronary artery disease and atherosclerosis