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Rheumatic fever is a bacterial infection that can cause problems with the heart's aortic and mitral valves.
Rheumatic fever is caused by certain strains of streptococcal bacteria. A strep throat infection that isn't properly treated can trigger rheumatic fever. Rheumatic fever can damage heart muscle and heart valves. Not all people who have rheumatic fever develop rheumatic heart disease.
This infection causes swelling and muscle damage to the heart. It can also damage the heart valves in a way that keeps the blood from moving through the heart normally. The infection can cause heart valve leaflets to stick together, which narrows the valve opening. Also, the infection can scar the valves. This keeps the valves from closing tightly, so blood leaks backward in the heart.
If the aortic valve is narrowed, this problem is called aortic valve stenosis.
If the mitral valve is narrowed, this problem is called mitral valve stenosis.
If the valve does not close tightly and blood leaks backward, the problem is called aortic valve regurgitation or mitral valve regurgitation.
Rheumatic fever is rare in Canada, the United
States, and western Europe. But it was fairly common until the 1950s.
Widespread use of antibiotics to treat strep throat has greatly lowered the number of new cases of rheumatic fever.
Today, most rheumatic fever
cases occur in developing countries, particularly Africa and southeast
Some people may develop a heart valve disease after having
rheumatic fever as a child. It might take a few years to 20 years or more
after a case of rheumatic fever for a valve problem to develop.
Other Works Consulted
Freeman RV, Otto CM (2011). Aortic valve disease. In V Fuster et al., eds., Hurst’s The Heart, 13th ed., vol. 2, pp. 1692–1720. New York: McGraw-Hill.
Otto CM, Bonow RO (2012). Valvular heart disease. In RO Bonow et al., eds., Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 9th ed., vol. 2, pp. 1468–1539. Philadelphia: Saunders.
November 11, 2013
Rakesh K. Pai, MD, FACC - Cardiology, Electrophysiology
& David C. Stuesse, MD - Cardiac and Thoracic Surgery
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