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Rh disease is a serious pregnancy problem that can affect a baby
(fetus) with Rh-positive blood if the mother has Rh-negative blood. Because
their blood types don't match, the mother's immune system will make antibodies
that destroy the fetus's red blood cells, which can lead to anemia, jaundice,
and dangerous swelling.
Rh disease is also called hemolytic disease of the newborn or
Rh disease is the result of Rh sensitization, which causes the Rh-negative mother to make antibodies
that attack the fetus's Rh-positive red blood cells. The more red blood cells
are destroyed, the worse the effect on the fetus. In severe cases, the baby may
die before or after birth.
Rh sensitization usually happens during childbirth, so a fetus in a
first pregnancy may not have Rh disease. But each future Rh-positive fetus will
be at risk, and Rh disease tends to be worse with each Rh-positive pregnancy.
In some cases, a fetus in a first pregnancy does have Rh disease.
This can happen if the mother was Rh sensitized during a miscarriage, abortion,
or ectopic pregnancy or because of a test that causes bleeding in the uterus
during pregnancy, such as an amniocentesis or chorionic villus sampling. A
blood test can show if a woman has Rh sensitization and whether her baby is at
Treatment for Rh disease depends on how severe the disease is,
which can be checked with regular testing throughout the pregnancy. A fetus
with mild Rh disease may not need any special treatment. One who is more
severely affected may need to have a blood transfusion while still in the
uterus and to be delivered early.
A woman with Rh sensitization is likely to be cared for by a
high-risk pregnancy specialist (perinatologist).
Current as of:
June 4, 2014
Sarah Marshall, MD - Family Medicine & William Gilbert, MD - Maternal and Fetal Medicine
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