Prediabetes: Progression to Type 2 Diabetes

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After 3 years, about 14 out of 100 people who made major lifestyle changes got type 2 diabetes. Compare that to about 22 out of 100 people who took metformin and about 29 out of 100 people who took a placebo pill and got type 2 diabetes. After 10 years, about 27 out of 100 people who made major lifestyle changes got type 2 diabetes. Compare that to about 42 out of 100 people who took metformin and about 52 out of 100 people who took a placebo pill and got type 2 diabetes.

Making major lifestyle changes and taking metformin both work better than a placebo pill at delaying or preventing type 2 diabetes. For many people, making major lifestyle changes works better to help delay or prevent type 2 diabetes than taking metformin does.

These numbers apply to many people. But for women who have had gestational diabetes or people who have a BMI of 35 or more, either making major lifestyle changes or taking metformin works very well to delay or prevent type 2 diabetes. Many people age 60 and older benefit more from making major lifestyle changes. And many people younger than 60 benefit more from taking metformin.

For some people, making major lifestyle changes or taking metformin can help delay or prevent type 2 diabetes for 10 years or more. But doing both of these things may give you the best chance of delaying or preventing type 2 diabetes over the long term.

The information shown here is based on the best available evidence.

ByHealthwise Staff
Primary Medical ReviewerAdam Husney, MD - Family Medicine
Kathleen Romito, MD - Family Medicine
Specialist Medical ReviewerMatthew I. Kim, MD - Endocrinology
Carol M. Mangione, MD, MPH - Internal Medicine
O. Kenrik Duru, MD - Internal Medicine

Current as ofJuly 28, 2015

Current as of: July 28, 2015

Author: Healthwise Staff

Medical Review: Adam Husney, MD - Family Medicine & Kathleen Romito, MD - Family Medicine & Matthew I. Kim, MD - Endocrinology & Carol M. Mangione, MD, MPH - Internal Medicine & O. Kenrik Duru, MD - Internal Medicine