Afif Hentati, M.D.

Afif Hentati, M.D.

Afif Hentati, M.D.

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Personal Bio

Treatment Philosophy

I treat patients as if they were part of my own family.

Personal Interests

I enjoy spending time with my family.

Conditions & Procedures


Abnormal Magnetic Resonance Imaging (MRI), Baclofen Pump, Complicated Migraines, Demylinating Disease, Devic Disease, Dizziness, Facial Pain, Gait Abnormailty, Gait Issues, General Neurology, General Weakness, Head Pain, Headache, Hereditary Spastic Paraplegia, Migraine Headaches, Multiple Sclerosis (MS), Neck Pain, Optic Neuritis, Pain in Limbs, paresthesias, Spastic Paraparesis, Spasticity, Syncope, Transverse Myelitis, Trigeminal Neuralgia, Twitch, Vertigo

General Information




NorthShore Medical Group


Neurology, Multiple Sclerosis

Academic Rank

Clinical Assistant Professor


Arabic, English, French

Board Certified


Clinical Service

Education, Training & Fellowships

Medical School

Faculté de médecine de Sfax, 1984


University Hospitals of Sfax, 1986


University Hospitals in Tunisia, 1990
Northwestern Feinberg School of Medicine, 2001


McGaw Medical Center of Northwestern University, 1998



NorthShore Medical Group

1000 Central St.
Suite 880
Evanston, IL 60201
847.570.2570 847.570.2073 fax Get Directions This location is wheelchair accessible.

NorthShore Medical Group

2180 Pfingsten Rd.
Suite 2000
Glenview, IL 60026
847.570.2570 847.570.2073 fax Get Directions This location is wheelchair accessible.

NorthShore Medical Group

9650 Gross Point Rd.
Suite 3900
Skokie, IL 60076
847.570.2570 847.657.5708 fax Get Directions This location is wheelchair accessible.


Commercial Plans
  • Aetna Choice POS
  • Aetna Elect Choice EPO and EPO
  • Aetna Health Network Options
  • Aetna HMO
  • Aetna Managed Choice
  • Aetna Managed Choice POS
  • Aetna Open Choice PPO
  • Aetna Open Choice PPO (Aetna HealthFund)
  • Aetna QPOS
  • Aetna Savings Plus
  • Aetna Select
  • Beechstreet PPO Network
  • Blue Cross Blue Shield - PPO Products
    Not Contracted Blue Cross Blue Shield Blue Choice PPO
  • Blue Cross Blue Shield Blue Advantage
  • Blue Cross Blue Shield HMOI
  • Cigna HMO
  • Cigna LocalPlus
  • Cigna Open Access Plus (OAP)
  • Cigna Open Access Plus with CareLink (OAPC)
  • Cigna POS
  • Cigna PPO
  • Cofinity PPO (an Aetna Company)
  • Coventry Health Care Elect Choice EPO
  • Coventry Health Care First Health PPO
  • Galaxy Health PPO Network
  • Great West PPO/POS
  • Healthcare's Finest Network (HFN)
  • Humana - All Commercial Plans (including Choice Care)
  • Humana - NorthShore Complete Care
  • Humana/ChoiceCare Network PPO
  • Medicare
  • Multiplan and PHCS PPO Network (Including PHCS Savility)
  • NorthShore Employee Network
  • Preferred Plan PPO
  • Three Rivers Provider PPO Network (TRPN)
  • Tricare
  • Unicare
  • United Healthcare - All Commercial Plans
    Not Contracted United Healthcare Core
    Not Contracted United Healthcare Navigate
Exchange Plans
  • Aetna Whole Health Chicago
  • Not Contracted Blue Cross Blue Shield - PPO Products
    Not Contracted Blue Cross Blue Shield Blue Choice PPO
  • Blue Cross Blue Shield Blue Precision HMO
  • Coventry (PPO)
  • Harken Health - an Affiliate of United Healthcare
    Verify physician participation and out of pocket expenses with Harken
  • Land of Lincoln Health Traditional PPO
  • Not Contracted United Healthcare Compass
  • Illinois Department of Public Aid (IDPA)
  • Illinicare ICP
  • Community Care Partners
Medicare Advantage Plans
  • Aetna Medicare (SM) Plan (HMO)
  • Aetna Medicare (SM) Plan (PPO)
  • Blue Cross Blue Shield Medicare Advantage PPO Plan
  • Cigna-HealthSpring Advantage HMO
  • Cigna-HealthSpring Premier HMO-POS
  • Cigna-HealthSpring Primary HMO
  • Humana Gold Plus HMO
  • Humana Gold Plus PFFS
  • HumanaChoice PPO
  • United Healthcare - All Medicare Plans
Medicare Medicaid Alignment Initiative (MMAI) Plans
  • Blue Cross Blue Shield Community
  • HealthSpring
  • Humana
  • Illinicare Health Plan
  • Meridian Complete


  • Dendriform pulmonary ossification in a patient with mucoepidermoid carcinoma.

    Asian cardiovascular & thoracic annals 2016 Jul

    Authors: Triki M, Kallel R, Hentati A, Hentati Y, Mnif H, Boudawara T
    Dendriform pulmonary ossification is a chronic process characterized by the presence of heterotopic bone within the interstitium and alveolar walls. It usually occurs in the setting of chronic inflammation. We report an unusual case of a 54-year-old man with a history of relapsing Hodgkin lymphoma who was diagnosed with concomitant mucoepidermoid pulmonary carcinoma and dendriform ossifications. The radiological features were initially misinterpreted as post-radiation pulmonary fibrosis and bronchiectasis. The diagnosis was finally established after considering both the radiological and pathological findings. Dendriform pulmonary ossification is an under-recognized disease that should be considered in the differential diagnosis of lung chronic diseases.
    PMID: 27252231 [PubMed - as supplied by publisher]
  • Left lung agenesis discovered by a spontaneous pneumothorax in a 20-year-old girl.

    Lung India : official organ of Indian Chest Society

    Authors: Hentati A, Neifar C, Abid W, M'saad S
    Lung agenesis is a rare condition which prognosis widely depends on associated malformations. Clinical presentation is so variable and diagnosis is often made in childhood. Here, we present a case of a 20-year-old girl who was admitted because of a spontaneous pneumothorax. Explorations concluded at a left lung agenesis, a hyperinflated right lung crossing the midline with a corresponding pneumothorax. There was no malformation else. This congenital condition and treatment for this rare presentation are discussed in detail.
    PMID: 27051112 [PubMed - as supplied by publisher]
  • [Hydatid cysts of the liver ruptured into the thorax (about five cases)].

    Revue de pneumologie clinique 2015 Oct

    Authors: Msaad S, Yangui I, Ketata W, Abid N, Feki W, Abid H, Hentati A, Kammoun S
    Hydatid cyst of the liver remains a serious public health problem in Tunisia. This benign affection can sometimes cause fatal complications such as cyst rupture into the thorax.
    We report 5 cases of patients who experienced intrathoracic rupture of hydatic cyst of liver. There were four rural women and an urban man. Patients were between 60 and 75 years of age. We present 2 cases of cyst rupture into pleura, 3 cases of hydatid bronchial fistula and 3 cases of biliothoracic fistulas. Surgical treatment was performed by laparotomy in 3 cases, thoracic approach in one case and by thoracoabdominal approach in the other case. We deplore one case of early death by hemorrhagic shock.
    Authors emphasize the complexity of the management of hydatic cyst of liver ruptured into the thorax. Surgical treatment remains responsible of high perioperative morbidity and mortality. Early diagnostic and improvement of reanimation measures are important to improve the prognosis of this serious complication.
    PMID: 26195113 [PubMed - as supplied by publisher]
  • Primary Burkitt lymphoma in the posterior mediastinum.

    Asian cardiovascular & thoracic annals 2015 Nov

    Authors: Chaari Z, Charfi S, Hentati A, Ayadi I, Abid H, Frikha I
    A 13-year-old boy was admitted to our hospital with complaints of posterior chest pain and dyspnea. Computed tomography and magnetic resonance imaging of the chest revealed a mass in the posterior mediastinum, extending from T8 to T11 with intraspinal involvement. A percutaneous core needle biopsy confirmed the diagnosis of Burkitt lymphoma. He was treated according to the Lymphoma Malignancy B protocol 2001 arm C3, but he presented with liver and brain relapses and died 7.5 months after admission. Although lymphoma is rarely localized in the posterior mediastinum, it should be considered in the differential diagnosis of posterior mediastinal masses in children.
    PMID: 26038605 [PubMed - as supplied by publisher]
  • Giant cystic schwannoma of the middle mediastinum with cervical extension.

    The Libyan journal of medicine 2015

    Authors: Gueldich M, Hentati A, Chakroun A, Abid H, Kammoun S, M'saad S, Frikha I
    Schwannomas (neurilemmomas) are benign tumors arising from the Schwann cells of the neural sheath. They are typically, well-encapsulated lesions which rarely adhere to the adjacent structures. In the chest, schwannomas are often seen within the posterior mediastinum and commonly originating along intercostal nerves. Several operative approaches have previously been described for the resection of these tumors, including thoracoscopic techniques and posterolateral thoracotomy. We report in this case a giant cystic mediastinal schwannoma of the left recurrent laryngeal nerve with cervical extension, unresectable by the usual described approaches, which was completely removed through a cervical approach.
    PMID: 25854982 [PubMed - as supplied by publisher]
  • Live cell imaging of the nascent inactive X chromosome during the early differentiation process of naive ES cells towards epiblast stem cells.

    PloS one 2014

    Authors: Guyochin A, Maenner S, Chu ET, Hentati A, Attia M, Avner P, Clerc P
    Random X-chromosome inactivation ensures dosage compensation in mammals through the transcriptional silencing of one of the two X chromosomes present in each female cell. Silencing is initiated in the differentiating epiblast of the mouse female embryos through coating of the nascent inactive X chromosome by the non-coding RNA Xist, which subsequently recruits the Polycomb Complex PRC2 leading to histone H3-K27 methylation. Here we examined in mouse ES cells the early steps of the transition from naive ES cells towards epiblast stem cells as a model for inducing X chromosome inactivation in vitro. We show that these conditions efficiently induce random XCI. Importantly, in a transient phase of this differentiation pathway, both X chromosomes are coated with Xist RNA in up to 15% of the XX cells. In an attempt to determine the dynamics of this process, we designed a strategy aimed at visualizing the nascent inactive X-chromosome in live cells. We generated transgenic female XX ES cells expressing the PRC2 component Ezh2 fused to the fluorescent protein Venus. The fluorescent fusion protein was expressed at sub-physiological levels and located in nuclei of ES cells. Upon differentiation of ES cell towards epiblast stem cell fate, Venus-fluorescent territories appearing in interphase nuclei were identified as nascent inactive X chromosomes by their association with Xist RNA. Imaging of Ezh2-Venus for up to 24 hours during the differentiation process showed survival of some cells with two fluorescent domains and a surprising dynamics of the fluorescent territories across cell division and in the course of the differentiation process. Our data reveal a strategy for visualizing the nascent inactive X chromosome and suggests the possibility for a large plasticity of the nascent inactive X chromosome.
    PMID: 25546018 [PubMed - as supplied by publisher]
  • VZV encephalitis that developed in an immunized patient during fingolimod therapy.

    Neurology 2015 Jan 6

    Authors: Michel S, de Sanctis A, Hentati A, Lenoir S, Caliandro R, Gossot D
    Spontaneous regression of an epithelial thymic tumour has been reported but seems extremely rare. Its mechanism is unknown.
    We report two cases of epithelial thymic tumour, either histologically proven or highly suspected on imaging, that regressed spontaneously (partially in one patient and totally in the other).
    Spontaneous regression of an epithelial thymic tumour is very rare but this possibility could lead to clinical and radiological monitoring rather than surgery in selected patients.
    PMID: 25416038 [PubMed - as supplied by publisher]
  • Thoracoscopic partial thymectomy for untraceable mediastinal parathyroid adenomas.

    Interactive cardiovascular and thoracic surgery 2011 Nov

    Authors: Hentati A, Gossot D
    Despite accurate preoperative imaging, ectopic mediastinal parathyroid adenomas can be difficult to find via a thoracic approach. Considering that - in most cases - these adenomas are intrathymic, it can be advisable to directly perform a partial thymectomy. We present the cases of three patients who were successfully cured using a thoracoscopic partial thymectomy.
    PMID: 21873366 [PubMed - as supplied by publisher]
  • Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration.

    American journal of human genetics 2008 Feb

    Authors: Tsaousidou MK, Ouahchi K, Warner TT, Yang Y, Simpson MA, Laing NG, Wilkinson PA, Madrid RE, Patel H, Hentati F, Patton MA, Hentati A, Lamont PJ, Siddique T, Crosby AH
    The hereditary spastic paraplegias (HSPs) are a genetically and clinically heterogeneous group of upper-motor-neuron degenerative diseases characterized by selective axonal loss in the corticospinal tracts and dorsal columns. Although numerous mechanisms involving defective subcellular transportation, mitochondrial malfunction, and increased oxidative stress have been proposed, the pathogenic basis underlying the neuronal loss is unknown. We have performed linkage analysis to refine the extent of the SPG5 disease locus and conducted sequence analysis of the genes located within this region. This identified sequence alterations in the cytochrome P450-7B1 (CYP7B1) associated with this pure form of HSP. In the liver, CYP7B1 offers an alternative pathway for cholesterol degradation and also provides the primary metabolic route for the modification of dehydroepiandrosterone neurosteroids in the brain. These findings provide the first direct evidence of a pivotal role of altered cholesterol metabolism in the pathogenesis of motor-neuron degenerative disease and identify a potential for therapeutic intervention in this form of HSP.
    PMID: 18252231 [PubMed - as supplied by publisher]

In the News

Feb 2014