Projects that focus on building dynamic system models to improve treatment and care of patients with gastrointestinal disease are of key importance to the Center for the Study of Complex Disease. These projects include studies of Inflammatory Bowel Disease (IBD) and Crohn’s Disease as well as other related gastrointestinal diseases or conditions. The models address both the underlying mechanisms of disease as well as issues critical to improving treatment.

  • Factors affecting discontinuation of treatment with Infliximab in patients with Crohn’s disease
  • Cardiac toxicity from Domperidone
  • Predicting the effect of a smoking cessation program in patients with Crohn’s disease
  • A simulated comparison of topical and oral formulations of 5-aminosalicylate for the remission and maintenance of UC
  • Autoimmune diseases associated with celiac disease
  • Complications of Inflammatory Bowel Disease and Irritable Bowel Syndromes
  • The psychobiology of Crohn’s disease
  • Influence of alterations in gastric emptying: Implications for development of obesity