Michael S. Caplan, MDDepartment of Pediatrics

Chief Scientific Officer
Research Institute

Contact Information


  • Undergraduate: BS, Biology, University of Illinois
  • Medical School: MD, Medicine, Pritzker School of Medicine, University of Chicago
  • Residency: Pediatrics, Children's Memorial Hospital, Northwestern University, Chicago, IL
  • Fellowship: Neonatology, Northwestern University, Chicago, IL

Research Interests
To understand the pathophysiology of neonatal necrotizing enterocolitis, and to design specific strategies to prevent the disease.

Honors and Awards

  • Graduated with honors, Pritzker School of Medicine, University of Chicago, 1984
  • Best Resident Teacher, 1984-1985
  • Kenney Award, Best Fellow Presentation, Midwest Society of Pediatric Research, 1989
  • Sutherland Award for best research presentation by young faculty, Midwest Society for Pediatric Research, 1991
  • Speaker, NIH NEC symposium, 1993
  • NIH Clinical Investigator Award, 1993-1998
  • Editor, Clinics in Perinatology, June 1995
  • Research Scholar Award, Women's Auxiliary, Evanston Hospital Corporation, 1995-1998
  • Chairman, Pediatric Research NEC symposium, 1997
  • Chairman, Symposium on NEC, Society for Pediatric Research, 1998
  • Jonas Salk Health Services Award, March of Dimes, 2000
  • Chairman, Neonatology Disease-Oriented Research, SPR, 2000

Professional Memberships/Affiliations/Activities

  • American Academy of Pediatrics
  • American Academy of Pediatrics, Illinois Chapter: Fetus and Newborn Committee, Chairperson
  • Perinatal Association of Illinois
  • Midwest Society for Pediatric Research, Council member
  • Society for Pediatric Research
  • International Society for Research in Human Milk and Lactation

Scholarly Work

Publications in Peer-Review Journals:

  1. Amer M, Adler A, Jilling T, Caplan M: Stool PAF levels in neonatal necrotizing enterocolitis.  Biol Neonate, submitted, 2003.
  2. Qu X, Rozenfeld R, Zhu Y, Chen J, De Plaen IG, Caplan MS, and Hsueh W: Tetrahydrobiopterin prevents platelet-activating factor-induced bowel necrosis: Role of neuronal nitric oxide synthase.  Gut, submitted, 2003.
  3. Lu J, Caplan MS, Li D, Adler L, Saraf A, Liu X, Jilling T: Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells.  Amer J Physiol, submitted, 2003.
  4. Thaete L,   Neerhof MG, Jilling T, Caplan MSInfusion of exogenous PAF produces IUGR in the rat.  J Soc Gynecol Investig; 10145-150, 2003.
  5. Amer M, Adler L, Yu Xiao, Jilling T, and Caplan M: The role of phospholipase A2 in a neonatal rat model of NEC: J Pediatr Gastro Nutr, submitted, 2003.
  6. Hammerman C, Goldschmidt D, Caplan MS, Kaplan M, Bromiker R, Eidelman AI, Gartner LM, Hochman A.  Protective effect of bilirubin in ischemia-reperfusion injury in the rat intestine.  J Pediatr Gastroenterol Nutr; 35:344-9, 2002.
  7. Claud EC, Li D, Xiao Y, Caplan MS, Jilling T:  Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers.  Pediatr Res.  52:155-162, 2002.
  8. Caplan, MS, Jilling T: The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis.  Lipids. 36:1053-1057, 2001.
  9. Caplan MS, Russell T, Xiao Y, Amer M, Kaup S, Jilling T: Effect of polyunsaturated fatty acid supplementation on intestinal inflammation and necrotizing enterocolitis in a neonatal rat model.  Pediatr Res 49:647-652, 2001.
  10. Tan X, Chang H, Qu X, Caplan M, Gonzalez-Crussi F, Hsueh W: Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin.  Br J Pharmacol, 129:1522-1529, 2000.
  11. Hammerman C, Goldschmidt D, Caplan MS, Kaplan M, Schimmel MS, Eidelman AI, Branski D, Hochman A: Amelioration of ischemia-reperfusion injury in rat intestine by pentoxifylline-mediated inhibition of xanthine oxidase.  J Pediatr Gastroenterol Nutr 29:69-74, 1999.
  12. Caplan MS, Miller-Catchpole R, Kaup S, Russell T, Lickerman M, Amer M, Xiao Y, Thomson R: Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model.  Gastroenterol 117:577-583, 1999.
  13. Silver RK, Russell TL, Brodin AG, Check IJ, Helfand BT, Caplan MSVariability of murine pregnancy outcome resulting from passive immunization with anticardiolipin antibody-positive immunoglobulin G.  Maternal-Fetal Invest 8:35-38, 1998.
  14. Caplan MS, Lickerman M, Adler L, Dietsch GN, and Yu A: The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis.  Pediatr Res 42:779-883, 1997.
  15. Neerhof MG, Silver RK, Caplan MS, Thaete LG: Endothelin-1-induced placental and fetal growth restriction in the rat.  J Maternal Fetal Med 6:1-4, 1997.

Peer Review Service:

  • Journal of Pediatrics
  • Pediatrics
  • Pediatrics Research
  • Digestive Diseases and Sciences
  • Pediatric Pathology
  • Journal of Pediatric Gastroenterology and Nutrition
  • Fertility and Sterility
  • Free Radical Biology and Medicine
  • Molecular Genetics and Metabolism
  • Circulation
  • American Family Physician
  • FASEB Journal
  • JAMA
  • Pediatric Surgery International