Edward H. Mkrdichian, M.D.

Edward H. Mkrdichian, M.D.

Edward H. Mkrdichian, M.D.

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Personal Bio

Treatment Philosophy

My approach is to present the patient with all available options with utmost honesty and clarity. Engage them and their families in the decision making process based on my professional opinion without swaying or steering them toward a specific type of treatment. Always treat patients with the same compassion I would treat a member of my own family. I will do the absolute best I can for each and every patient.

Personal Interests

I have several outside interests, including participating in church activities and fundraising efforts, playing golf and reading, watching sports and news programs, and enjoying wine and food.

Conditions & Procedures

Conditions

Acoustic Neuroma, astrocytoma, Back Pain, Brain Bleed, Brain Tumor, Cervical/Lumbar Disc Disease, Chiari Malformation, Degenerative Spine Disease, Ependynoma, Glioblastoma, Glioma, Meningioma, Neoplasm, Pineal Cyst, Radiculopathy, Spinal Cord Tumors, Spinal Fractures, Spinal Stenosis, Subarachnoid Hemorrhage (SAH), Subdural Hematoma (SDH), Synovial Cysts, Syringomyelia, Vestibular Schwanoma

Procedures

Cervical and Lumbar Surgery, Stereotactic Neurosurgery and Radiosurgery (SRS), Stereotactic Radiosurgery of Spine

General Information

Gender

Male

Affiliation

NorthShore Medical Group

Academic Rank

Clinician Educator

Languages

Arabic, Armenian, Assyrian, English

Board Certified

Neurological Surgery

Clinical Service

Neurosurgery

Education, Training & Fellowships

Medical School

Rush Medical College, 1979

Residency

McGaw Medical Center of Northwestern University, 1985

Fellowship

Mayo Clinic, 1985

Locations

A

NorthShore Medical Group

2180 Pfingsten Rd.
Suite 2000
Glenview, IL 60026
847.570.1440 847.570.1442 fax This location is wheelchair accessible.
B

NorthShore Medical Group

1000 Central St.
Suite 880
Evanston, IL 60201
847.570.1440 847.570.1442 fax This location is wheelchair accessible.
C

NorthShore Medical Group

9650 Gross Point Rd.
Suite 2900
Skokie, IL 60076
847.570.1440 847.570.1442 fax This location is wheelchair accessible.

Insurance

Every effort has been made to ensure the accuracy of the information in this directory. However, some changes may occur between updates. Please check with your provider to ensure that he or she participates in your health plan.

Aetna HMO/PPO/POS
BCBS HMOI
BCBS PPO *except Blue Choice IL
Beechstreet PPO
CCN PPO
CIGNA Choice Fund
CIGNA Choice Fund PPO
CIGNA EPO
CIGNA Network
CIGNA Network Open Access
CIGNA POS
CIGNA POS Open Access
CIGNA PPO
CIGNA:Open Access Plus
First Health PPO
Galaxy PPO
Great West POS
Great West PPO
Healthcares Finest Network PPO
Humana Choice Care PPO
Humana IPA--HMO
Humana POS
Humana PPO
Land of Lincoln
Medicare
Multiplan Admar PPO
Multiplan Formost PPO
Multiplan Health Network PPO
Multiplan Wellmark PPO
NorthShore Employee Network I (EPO Option)
NorthShore Employee Network II (EPO Plus & CDHP)
PHCS PPO
Preferred Plan PPO
Railroad Medicare - Cook County
Railroad Medicare - Lake County
UHC *except Core & Navigate
Unicare PPO

Publications

  • The identification of novel therapeutic targets for the treatment of malignant brain tumors.

    Cancer letters 2000 Aug 11

    Authors: Kroes RA,
    Abstract
    A two-step strategy was developed consisting of differential display reverse transcriptase polymerase chain reaction (DDRT-PCR) with cultured normal human fetal astrocytes and U-373MG glioma cells followed by reverse Northern analysis of normal brain and primary tumor tissues. hu-dek, alpha-NAC, ribosomal proteins L7a and L35a, and five novel genes were identified. Since none of these genes has been previously shown to be associated with malignant brain tumor formation, this approach may be useful to identify novel targets for the diagnosis and treatment of brain tumors.
    PMID: 10880769 [PubMed - as supplied by publisher]
  • Beta1,6-N-acetylglucosamine-bearing N-glycans in human gliomas: implications for a role in regulating invasivity.

    Cancer research 2000 Jan 1

    Authors: Yamamoto H,
    Abstract
    The metastatic potential of tumor cells has been shown to be correlated with the expression of tri- and tetra-antennary beta1,6-N-acetylglucosamine (beta1,6-GlcNAc)-bearing N-glycans, which are recognized by Phaseolus vulgaris leukoagglutinating lectin (L-PHA). The expression of beta1,6-GlcNAc-bearing N-glycans also has been used as a marker of tumor progression in human breast and colon cancers. In this report, the role of N-glycan branching in regulating glioma migration and invasion was examined. The expression of beta1,6-GlcNAc-bearing N-glycans was found in human glioma specimens, whereas astrocytes from normal adult brain were negative. The expression of N-acetylglucosaminyltransferase V (GnT-V) mRNA, which is responsible for the biosynthesis of beta1,6-GlcNAc-bearing N-glycans, was high in glioma cell lines with robust ets-1 expression. To study the molecular mechanism of GnT-V expression in human glioma cells, an inducible ets-1 gene was stably transfected into SNB-19 cells using a tetracycline repressor system. GnT-V mRNA expression was increased by the induction of c-ets-1, suggesting that the Ets-1 transcription factor directly regulates the transcription of GnT-V. Stable transfection of GnT-V into human glioma U-373 MG cells resulted in changes in cell morphology and focal adhesions and a marked increase in glioma invasivity in vitro. L-PHA has little effect on cell migration. On the contrary, Phaseolus vulgaris erythroagglutinating lectin (E-PHA), which recognizes bisecting beta1,4-GlcNAc-bearing N-glycans, strongly inhibits cell migration (haptotaxis) on a fibronectin substrate in U-373 MG transfectants and other glioma cell lines tested. These results suggest that the increased beta1,6-GlcNAc-bearing N-glycan expression found in malignant gliomas is modulated by GnT-V through the Ets-1 transcription factor, and that the branching of complex type N-glycans plays a major role in glioma invasivity.
    PMID: 10646865 [PubMed - as supplied by publisher]
  • alpha2,3-sialyltransferase mRNA and alpha2,3-linked glycoprotein sialylation are increased in malignant gliomas.

    Brain research 1997 Apr 25

    Authors: Yamamoto H,
    Abstract
    CMP-NeuAc: Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase (alpha2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of alpha2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of alpha2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.
    PMID: 9163557 [PubMed - as supplied by publisher]
  • The expression of CMP-NeuAc: Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase [EC 2.4.99.1] and glycoproteins bearing alpha 2,6-linked sialic acids in human brain tumours.

    Glycoconjugate journal 1995 Dec

    Authors: Yamamoto H,
    Abstract
    The expression of CMP-NeuAc: Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase (alpha 2,6-ST) [EC 2.4.99.1] and glycoproteins bearing alpha 2,6-linked sialic acids were examined in primary human brain tumours and cell lines. 79% (19/24) of the meningiomas expressed alpha 2,6-ST mRNA, 42% (10/24) of which showed very high expression. alpha 2,6-ST mRNA expression was undetectable in normal brain tissue. In contrast, only 1/13 of the gliomas examined expressed detectable alpha 2,6-ST mRNA. Metastases to the brain did not express measurable amounts of alpha 2,6-ST mRNA. Less expression was found in malignant (i.e. anaplastic) compared to benign (i.e. meningothelial) meningiomas. Two-dimensional SDS-PAGE of glioma and meningioma proteins, followed by Sambucus nigra lectin staining, revealed the presence of a glycoprotein bearing alpha 2,6-linked sialic acids, M(r) = 53 kDa and a pI = 7.0 (MEN-1) that appeared in all seven of the meningiomas examined, but was expressed at barely detectable levels, if at all, in seven out of the seven glioblastomas examined. Thus, decreased alpha 2,6-ST expression may play a role in the aggressive nature of anaplastic meningiomas, but appears to be virtually absent in all tumours of glial origin.
    PMID: 8748163 [PubMed - as supplied by publisher]
  • Acoustic nerve tumor surgery before and since the laser: comparison of results.

    Lasers in surgery and medicine 1987

    Authors: Cerullo LJ, Mkrdichian EH,
    Abstract
    A random computer selection of 21 patients who underwent 28 operations for acoustic neurinoma between 1974 and 1980 using conventional methods, including the operating microscope and microtechnique, was compared with a cohort of 22 patients who underwent 25 operations between 1980 and 1984 utilizing a carbon dioxide laser. Completeness of tumor removal, anatomical and functional preservation of the facial nerve, preservation of hearing, morbidity and mortality, average hospital stay, and eventual outcome were used as markers and were compared. Utilizing P values, the study demonstrated a significantly superior outcome, and as a result a better life quality, in patients who were operated on utilizing a CO2 laser in addition to conventional microsurgical technique.
    PMID: 3626745 [PubMed - as supplied by publisher]
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