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Jubao Duan, PhD

Department of Psychiatry and Behavioral Sciences
Center for Psychiatric Genetics

Contact Information
224.324.7564
224.324.7570 fax
jduan@northshore.org

Education

  • Undergraduate: B.S., Department of Biochemistry; Shandong University; Jinan, China
  • Graduate:
    • M.S., Molecular Genetics, Institute of Basic Medical Sciences, Beijing, China
    • Ph.D., Molecular Genetics, Institute of Basic Medical Sciences, Beijing, China
  • Postdoctoral Fellowship: Department of Psychiatry, University of Chicago, Chicago, USA

Research Interests

Linkage disequilibrium mapping of susceptibility genes for schizophrenia; Molecular mechanisms on how genetic polymorphisms confer susceptibility to psychiatric disorders; Expression and regulation of candidate genes of psychiatric disorders.

Honors and Awards

  • (2006) NARSAD Elizabeth Elser Doolittle Investigator
  • (2005) NARSAD (National Alliance for Research of Schizophrenia and Depression) Young Investigator Award
  • (2004) NorthShore University HealthSystem Research Career Development Award
  • (2003) Scholarship Program from Society of Biological Psychiatry-membership and annual meeting in San Francisco
  • (2001) NARSAD (National Alliance for Research of Schizophrenia and Depression) Young Investigator Award

Professional Memberships/Affiliations/Activities

  • American Society of Human Genetics
    Society of Biological Psychiatry

Scholarly Work

Publications in Peer-Review Journals:

  1. *Suarez BK, *Duan J (equal contribution), Sanders AR, Hinrichs, AL, Jin CH, Hou C, Buccola, NG, Hale N, Weilbaecher AN, Nertney DA, Olincy A, Green S, Schaffer AW, Smith CJ, Hannah DE, Rice JP, Cox NJ, Martinez M, Mowry BJ, Amin F, Silverman JM, Black DW, Byerley WF, Crowe RR, Freedman R, Cloninger CR, Levinson DF, and Gejman PV. Genomewide Linkage Scan of 409 European ancestry and African American Families with Schizophrenia: Suggestive Evidence for Linkage in 8p23.3-p12 and 11p11.2-q22.3 in the Combined Sample. Am J Hum Genet. 2006 Feb; 78(2):315-33.
  2. Duan J, Martinez M, Sanders AR, Hou C, Krasner AJ, Schwartz DB, Gejman PV. Neuregulin 1 (NRG1) and schizophrenia: analysis of a US family sample and the evidence in the balance. Psychol Med. 2005 Nov; 35(11):1599-610.PMID: 16219118.
  3. Sanders AR, Rusu I, Duan J, Vander Molen JE, Hou C, Schwab SG, Wildenauer DB, Martinez M, and Gejman PV. Haplotypic Association Spanning the 22q11.21 Genes COMT and ARVCF with Schizophrenia. Molecular Psychiatry. 10(4):353-65 (2005).
  4. Sanders AR, Duan J, Gejman PV. Complexities in psychiatric genetics. Int Rev Psychiatry. 2004 Nov; 16(4):284-93.
  5. Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV.  Polymorphisms in the Trace Amine Receptor 4 (TRAR4) Gene on Chromosome 6q23.2 Are Associated with Susceptibility to Schizophrenia. Am J Hum Genet. 75(4):624-38 (2004).
  6. Mowry BJ, Holmans PA, Pulver AE, Gejman PV, Riley B, Williams NM, Laurent C, Schwab SG, Wildenauer DB, Bauche S, Owen MJ, Wormley B, Sanders AR, Nestadt G, Liang KY, Duan J, Ribble R, Norton N, Soubigou S, Maier W, Ewen-White KR, DeMarchi N, Carpenter B, Walsh D, Williams H, Jay M, Albus M, Nertney DA, Papadimitriou G, O'Neill A, O'Donovan MC, Deleuze JF, Lerer FB, Dikeos D, Kendler KS, Mallet J, Silverman JM, Crowe RR, Levinson DF.  Multicenter linkage study of schizophrenia loci on chromosome 22q.  Mol Psychiatry. 9(8):784-95 (2004).
  7. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, et al.  Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12: 205-216 (2003).
  8. Duan J, Sanders AR, Vander Molen JE, Martinolich L, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, and Gejman PV. Polymorphisms in the 5'-untranslated region of the human serotonin receptor 1B(HTR1B) gene affect gene expression. Molecular Psychiatry 8:901-910 (2003).
  9. Duan J, Antezana MA.  Mammalian mutation pressure, synonymous codon choice, and mRNA degradation.  J Mol Evol. 57(6):694-701 (2003).
  10. Sanders AR, Duan J, Gejman PV. DNA variation and psychopharmacology of the human serotonin receptor 1B (HTR1B) gene. Pharmacogenomics, 3(6):745-762 (2002).
  11. Duan J, Cai X,  Wang L, Zhang S, Wang J. Apoptosis induced by an IL-6Ra mutant in the multiple myeloma cell AF-10. IUBMB Life 49(1): 23-5 (2000).
  12. Duan J, Cai X, Zhang B, Li Y, Zou M, Wang J. The efficient secretion of human endostatin in yeast Pichia Pastoris. Biotechnology Letters 21:1095-1099 (1999).
  13. Zhou L, Wang  J, Peng S, Duan J, Cai X, Zou M, Su Q. High level expression of human interleukin-17 in yeast Pichia Pastoris. Biochemistry and Molecular Biology International 46(6):1109-16 (1998).
  14. Duan J, Wang J, Cai X, Wang L, Liu H, Zou M. Characterization of a soluble IL-6Ra mutant C277D/H280I expressed in E. coli. Biochemistry and Molecular Biology International, 41:1101-1108 (1997).
  15. Duan J, Cai X, Zhou L, Wang J. Single-step method of total RNA isolation by sodium-dodesyl-sulfate/phenol extraction from cultured cells. Analytical Biochemistry 251:291-292(1997).