Director, Unit of Functional Genomics in Psychiatry
Center for Psychiatric Genetics
Department of Psychiatry and Behavioral Sciences
Assistant Professor, University of Chicago Pritzker School of Medicine

Contact Information
224.324.7564
224.324.7570 fax
jduan@uchicago.edu;  jduan@northshore.org

Education

  • Undergraduate: B.S., Department of Biochemistry; Shandong University; Jinan, China
  • Graduate: Ph.D., Molecular Genetics, Institute of Basic Medical Sciences, Beijing, China
  • Postdoctoral Fellowship: Department of Psychiatry, University of Chicago, Chicago, USA

Research Interests

Molecular basis of schizophrenia and other psychiatric disorders; Functional genetics and genomics; Disease modeling by induced pluripotent stem cells (iPSC)-derived neurons; Genome editing; Gene expression and regulation.

Honors and Awards

  • (2011) NorthShore University HealthSystem Pilot Grant Award
  • (2006) NARSAD Elizabeth Elser Doolittle Investigator
  • (2005) NARSAD (National Alliance for Research of Schizophrenia and Depression) Young Investigator Award
  • (2004) NorthShore University HealthSystem Research Career Development Award
  • (2001) NARSAD (National Alliance for Research of Schizophrenia and Depression) Young Investigator Award

Professional Memberships/Affiliations/Activities

  • American Society of Human Genetics
  • Society of Psychiatric Genetics
  • American Society for Biochemistry and Molecular Biology

Scholarly Work

Publications in Peer-Review Journals: (from >70)

  1. Ripke S, Neale BM, Corvin A, …(52 others)…Duan J, Dudbridge F, …(>200 others)… Sullivan P, O'Donovan MC. Common variants analysis identifies 108 associated loci in schizophrenia. Nature, 2014. In press.
  2. Russell T, Blizinsky K, Cobia D, Cahill M, Xie Z, Sweet R, Duan J, Gejman PV, Wang L, Csernansky J, Penzes P. A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness. Nature Communications. 2014. In press.
  3. Shi J, Marconett CN, Duan J, Hyland PL, …(22 others)… Chatterjee N, Tucker MT, Caporaso NE, Chanock SJ, Laird-Offringa IA, Landi MT. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nature Communications. 2014 Feb 27;5:3365. PMID: 24572595.
  4. Shi S, Leites C, He D, Schwartz D, Moy M, Shi J, Duan J.  MicroRNA-9 and microRNA-326 regulate human dopamine D2 receptor expression and the microRNA-mediated expression regulation is altered by a genetic variant. J Biol Chem. 2014 Mar 27. [Epub ahead of print]. PMID: 24675081.
  5. Mulle JG, Pulver AE, McGrath JA, Wolyniec PS, Dodd AF, Cutler DJ, Sebat J, Malhotra D, Nestadt G, Conrad DF, Hurles M, Barnes CP, Ikeda M, Iwata N, Levinson DF, Gejman PV, Sanders AR, Duan J, Mitchell AA, Peter I, Sklar P, O'Dushlaine CT, Grozeva D, O'Donovan MC, Owen MJ, Hultman CM, Kähler AK, Sullivan PF; Molecular Genetics of Schizophrenia Consortium, Kirov G, Warren ST. Reciprocal duplication of the williams-beuren syndrome deletion on chromosome 7q11.23 is associated with schizophrenia. Biol Psychiatry. 2014 Mar 1;75(5):371-7. PMID: 23871472.
  6. Duan J, Shi J, Ge X, Dolken L, Moy W, He D, Shi S, Sanders AR, Ross J, Gejman PV. Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell lines. Sci Rep. 2013 Feb 20; 3:1318. doi: 10.1038/srep01318. PMID: 23422947.
  7. Sanders AR, Göring HH (co-first author), Duan J, Drigalenko EI, Moy W, Freda J, He D, Shi J; MGS, Gejman PV. Transcriptome study of differential expression in schizophrenia. Hum Mol Genet. 2013 Dec 15;22(24):5001-14. PMID: 23904455.
  8. Ripke S, O'Dushlaine C, Chambert K…(65 others)… Duan J, Eichhammer P…(114 others)… Sullivan PF. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013 Oct;45(10):1150-9. PMID: 23974872.
  9. Fanous AH, Zhou B, Aggen SH, Bergen SE, Amdur RL, Duan J, Sanders AR, Shi J, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Freedman R, Dudbridge F, Holmans PA, Ripke S, Gejman PV, Kendler KS, Levinson DF; Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. Am J Psychiatry. 2012 Dec 1;169(12):1309-17. PMID: 23212062.
  10. Chen L, Saccone NL, Culverhouse RC, …(19 others), Duan J, Eaton CB, …(37 others)… Bierut LJ. Smoking and Genetic Risk Variation across Populations of European, Asian, and African-American Ancestry - A Meta-analysis of Chromosome 15q25. Genet Epidemiol. 2012 May; 36(4):340-51. PMID: 22539395.
  11. Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, Lin DY, Duan J… 185  other authors …, O'Donovan MC, Daly MJ, Gejman PV. Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011 Sep 18;43(10):969-976. PMID: 21873549.
  12. Levinson DF, Duan J, Oh S, Wang K, Sanders AR, Shi J, Zhang N, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Kendler KS, Freedman R, Dudbridge F, Pe'er I, Hakonarson H, Bergen SE, Fanous AH, Holmans PA, Gejman PV. Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications. Am J Psychiatry. 2011 Feb 1. [Epub ahead of print]. PMID: 21285140.
  13. Lango Allen H, Estrada K, Lettre G,…(112 others), Duan J, …(many others)… Hirschhorn JN. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010 Oct 14;467(7317):832-8. Epub 2010 Sep 29. PMID: 20881960.
  14. Duan J, Sanders AR, Gejman PV. Genome-wide approaches to schizophrenia. Brain Res Bull. 2010 Sep 30;83(3-4):93-102. PMID: 20433910.
  15. Gejman PV, Sanders AR, Duan J. The role of genetics in the etiology of schizophrenia. Psychiatr Clin North Am. 2010 Mar;33(1):35-66. PMID: 20159339.
  16. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I, Dudbridge F, Holmans PA, Whittemore AS, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Crowe RR, Oksenberg JR, Mirel DB, Kendler KS, Freedman R, Gejman PV. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature. 2009 Aug 6;460(7256):753-7. PMID: 19571809.
  17. Sanders AR, *Duan J (co-first author), Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Buccola N, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Crowe RR, Cloninger CR, Martinez M, Gejman PV. No significant association of fourteen candidate genes to schizophrenia in a large European-ancestry sample: Implications for the field.  Am J Psychiatry. 2008 Apr;165(4):497-506. PMID:18198266.
  18. Duan J, Martinez M, Sanders AR, Hou C, Burrell GJ, Krasner AJ, Schwartz DB, Gejman PV.  DTNBP1 (Dystrobrevin Binding Protein 1) and schizophrenia: Association evidence in the 3’ end of the gene. Human Heredity. 2007 May; 64:97-106. PMID: 17476109.
  19. *Suarez BK, *Duan J (co-first author), Sanders AR, Hinrichs, AL, Jin CH, Hou C, Buccola, NG, Hale N, Weilbaecher AN, Nertney DA, Olincy A, Green S, Schaffer AW, Smith CJ, Hannah DE, Rice JP, Cox NJ, Martinez M, Mowry BJ, Amin F, Silverman JM, Black DW, Byerley WF, Crowe RR, Freedman R, Cloninger CR, Levinson DF, and Gejman PV. Genomewide Linkage Scan of 409 European ancestry and African American Families with Schizophrenia: Suggestive Evidence for Linkage in 8p23.3-p12 and 11p11.2-q22.3 in the Combined Sample. Am J Hum Genet. 2006 Feb; 78(2):315-33.
  20. Duan J, Martinez M, Sanders AR, Hou C, Krasner AJ, Schwartz DB, Gejman PV. Neuregulin 1 (NRG1) and schizophrenia: analysis of a US family sample and the evidence in the balance. Psychol Med. 2005 Nov; 35(11):1599-610.PMID: 16219118.
  21. Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV.  Polymorphisms in the Trace Amine Receptor 4 (TRAR4) Gene on Chromosome 6q23.2 Are Associated with Susceptibility to Schizophrenia. Am J Hum Genet. 75(4):624-38 (2004).
  22. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, et al.  Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12: 205-216 (2003).
  23. Duan J, Sanders AR, Vander Molen JE, Martinolich L, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, and Gejman PV. Polymorphisms in the 5'-untranslated region of the human serotonin receptor 1B(HTR1B) gene affect gene expression. Molecular Psychiatry 8:901-910 (2003).
  24. Duan J, Antezana MA.  Mammalian mutation pressure, synonymous codon choice, and mRNA degradation.  J Mol Evol. 57(6):694-701 (2003).
  25. Duan J, Cai X,  Wang L, Zhang S, Wang J. Apoptosis induced by an IL-6Ra mutant in the multiple myeloma cell AF-10. IUBMB Life 49(1): 23-5 (2000).
  26. Duan J, Cai X, Zhang B, Li Y, Zou M, Wang J. The efficient secretion of human endostatin in yeast Pichia Pastoris. Biotechnology Letters 21:1095-1099 (1999).
  27. Duan J, Cai X, Zhou L, Wang J. Single-step method of total RNA isolation by sodium-dodesyl-sulfate/phenol extraction from cultured cells. Analytical Biochemistry 251:291-292(1997).
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