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Larry G. Thaete , PhD

Sr. Research Scientist
Department of Obstetrics & Gynecology

Research Associate Professor
University of Chicago, Pritzker School of Medicine

Contact Information

 847.570.2372
 847.570.2910 Fax
mailto:lthaete@northshore.org

Education

  • Graduate School (MS):  Northern Arizona University, 1972
  • Graduate School (PhD):  Medical University of South Caroline, 1984
  • Post-doctoral Fellowship:  University of Colorado, 1991

Research and Academic Interests

  • Role of endogenous vasoactive mediators in the pathobiology of adverse pregnancy outcome
  • Mechanisms of receptor regulation and function
  • Cell and tissue ultrastructural morphology
  • Immunocytochemistry and histochemistry of proteins in normal and neoplastic tissues
  • Interactions between normal and neoplastic cells
  • Cancer prevention

Career Summary

Working with lung cancer-susceptible mice during my postdoctoral training at the University of Colorado, I showed by immunocytochemistry of proliferating cell nuclear antigen that several strains of mice exhibit significantly different type II and Clara cell proliferative rates, offering a possible basis for their differential susceptibility to lung tumorigenesis.  I then discovered a major difference in the number and distribution of corticosterone-producing cells (corticosterone depletion is known to increase lung tumorigenesis) in the adrenal cortex of A/J and C57BL/6J mice and 30 recombinant inbred strains derived from them, providing insight into another possible mechanism for the differences in susceptibility to lung tumorigenesis.  In addition, I provided evidence for the differential origin of lung tumors: solid lung tumors from type II pneumocytes and papillary tumors from bronchiolar Clara cells, by electron microscopy, immunocytochemistry, and enzyme histochemistry. Finally, I identified specific morphological effects of a metabolite of the food preservative, butylated hydroxytoluene, on both alveolar type II cells and bronchiolar Clara cells.

My research work in the Division of Maternal-Fetal Medicine at NorthShore University HealthSystem was focused on the treatment of fetal growth restriction (FGR).  I demonstrated reduced placental blood flow and decreased fetal weights in rats in response to maternal chronic endothelin infusion and to upregulated endogenous endothelin by hypoxia and by nitric oxide synthase inhibition. Upon further investigation I demonstrated restoration of normal blood flow and complete prevention of FGR by endothelin receptor A antagonism, using models of FGR based on hypoxia, nitric oxide synthase inhibition, and uterine ischemia/reperfusion.  Additionally, our research team showed that placental glycogen cells are particularly vulnerable to ischemic insult and that endothelin receptor antagonism provides protection for these cells in rodents.

My most recent research in the Division of Gynecologic Oncology has provided evidence that progesterone inhibits vitamin D-induced CYP24A1, thereby extending the active life of vitamin D and contributing to the prevention of ovarian cancer.

Honors and Awards

  • Award for Research Excellence at the 17th Annual Meeting of the Society of Perinatal Obstetricians (1997).
  • Outstanding Reviewer of 2015, Canadian Journal of Physiology and Pharmacology

Professional Memberships/Affiliations/Activities

  • Microscopy Society of America
  • The Histochemical Society
  • The American Association for Cancer Research
  • Christian Medical Association
  • Society for Reproductive Investigation
  • International Society for the Study of Hypertension in Pregnancy

Scholarly Work

Book Chapters:

  1. Crouch RK and Thaete LG.  Immunolocalization of CuZn SOD.  In: CRC Handbook of Methods for Oxygen Radical Research (Greenwald RA, ed.).  Boca Raton, FL: CRC Press, p. 271-275, 1985.
  2. Thaete LG.  Techniques for the elimination of artefacts in lead and uranium staining.  In: Procedures in Electron Microscopy (Robards AW and Wilson AJ, eds.). West Sussex, England: John Wiley & Sons, Chapter 5, Module 6, p. 34-36, 1993.

Professional Meeting Presentations:

  1.   Peters MA and Thaete LG.  Development of brain cereberosides and cerebroside sulfate (sulfatide) in offspring of control rats and rats chronically treated with methadone.  Fed Proc 35:385, 1976.

  2.   McMillan PJ, Hooker WM, Thaete LG and Wechbanjong N.  A stereological analysis of precarious rat odontoblasts.  Anat Rec 193:621, 1979.

  3.   Thaete LG, Spicer SS and Spock A.  Ultrastructural carbohydrate cytochemistry of human nasal mucosa.  Southeastern Electron Microscopy Society, Charleston, SC (abstracts not published), 1982.

  4.   Thaete LG, Crouch RK, Schulte BA and Spicer SS.  Copper- zinc superoxide dismutase localization in canine tissues.  J Histochem Cytochem 31:1068 (Abstract #31), 1983.

  5.   Thaete LG, Gunning WT, Stoner GD and Malkinson AM.  Evidence that pulmonary adenocarcinomas in mice are derived mainly from bronchiolar Clara cells.  Proc Am Assoc Cancer Res 27:41 (Abstract #159), 1986.

  6.   Thaete LG, Ahnen DJ and Malkinson AM.  Proliferating cell nuclear antigen (PCNA) immunocytochemistry as an index of cell proliferation in normal and regenerating mouse lung epithelia.  Fed Proc 46:997 (Abstract #3966), 1987.

  7.   Thaete LG, Ahnen DJ and Malkinson AM.  Proliferating cell nuclear antigen immunocytochemistry as an index of cell proliferation in response to toxicity.  Fifth Annual Meeting of the Mountain West Chapter of the Society of Toxicology (abstracts not published), 1987.

  8.   Thaete LG, Ahnen DJ and Malkinson AM. Use of PCNA (proliferating cell nuclear antigen) immunocytochemistry as a labeling index to assess cell proliferation in normal, regenerating, and neoplastic mouse lung epithelia.  Fifth International Meeting of the International Society of Differentiation, on the Differentiation of Normal and Neoplastic Cells, Boulder, CO (abstracts not published), 1987.

  9.   Malkinson AM, Thompson JA, Thaete LG and Blumenthal EJ. Potent promotion of lung tumors and induction of lung toxicity by a metabolite of butylated hydroxytoluene (BHT).  Conference on the Biology, Toxicology, and Carcinogenesis of Respiratory Epithelium, Albuquerque, NM (abstracts not published), 1988.

10.  Malkinson AM, Thompson JA, Thaete LG and Blumenthal EJ. Potent promotion of lung tumors and induction of lung toxicity by a metabolite of butylated hydroxytoluene (BHT).  Proc Am Assoc Cancer Res 30:206 (Abstract #819), 1989.

11.  Thaete LG, Ross D, Siegel D and Malkinson AM. DT-diaphorase histochemistry of normal and neoplastic mouse lung epithelial cells.  J Cell Biol 109:181a (Abstract #1001), 1989.

12.  Thaete LG, NesbittMN and Malkinson AM. Regulation of mouse lung tumor development by pulmonary adenoma histogenesis genes.  Proc Am Assoc Cancer Res 31:38 (Abstract #225), 1990.

13.  Forkert PG, Parkinson A, Thaete LG and Malkinson AM. Xenobiotic resistance of murine lung tumors to cytotoxicity. Proc Can Fed Biol Soc 35:47 (Abstract #029), 1992.

14.  Neerhof MG, Thaete LG, Silver RK, RaginAB and Caplan MS. Chronic endothelin (ET-1) infusion produces intrauterine growth restriction, fetal wastage and hypertension in the rat.  Pediatr Res 37:226A (Abstract #1342), 1995.

15.  Thaete LG, Magnuson SR and Neerhof MG. Uterine and placental endothelin (ET-1) receptor subtypes in the rat: Relationship to fetal and placental growth and organ perfusion.  Am J Obstet Gynecol 174:384 (Abstract #266), 1996.

16.  Thaete LG, Neerhof MG, Silver RK and Caplan MS. Chronic endothelin infusion in the rat: Effects on regional perfusion and pregnancy outcome.  Am J Obstet Gynecol 174:384 (Abstract #265), 1996.

17.  Thaete LG, Neerhof MG, Silver RK, Caplan MS and Brodin AG. Chronic endothelin infusion in the pregnant rat: Hemodynamic, biochemical, and placental histologic effects.  Am J Obstet Gynecol 174:386 (Abstract #275), 1996.

18.  Thaete LG and Neerhof MG. Endothelin subtype A receptor antagonism normalizes hypoxia-induced intrauterine growth restriction. J Soc Gynecol Invest 3:62A (Abstract #8), 1996.

19.  Thaete LG and Neerhof MG. Endothelin at pathophysiologic serum levels produces intrauterine growth restriction in the absence of maternal hypertension in the rat.  Hypertension in Pregnancy 16:88 (presented in 1996, published in 1997).

20.  Neerhof MG and Thaete LG. Chronic NOS-inhibition-induced IUGR is associated with increased circulating endothelin-1 levels in the rat.  Hypertension in Pregnancy 16:319 (presented in 1996, published in 1997).

21.  Thaete LG, Neerhof MG, Gosnell ER and Kushner DM.  Placental perfusion is decreased in a dose-dependent fashion in chronic NOS-inhibition-induced IUGR.  Am J Obstet Gynecol 176:S164 (Abstract #569), 1997.

22.  Neerhof MG and Thaete LG.  The contribution of endothelin to the regulation of maternal blood pressure in the pregnant rat: observations with and without chronic nitric oxide synthase inhibition.  J Soc Gynecol Invest 5 (Suppl.):68A (Abstract #114), 1998.

23.    Thaete LG and Neerhof MG.  Endothelin receptor antagonism does not prevent nitric oxide synthase inhibition-induced intrauterine growth restriction.  J Soc Gynecol Invest 5 (Suppl.):145A (Abstract #440), 1998.

24.    Thaete LG and Neerhof MG.  Apoptosis in L-NAME-treated rats is unaffected by ETA antagonism.  Hypertension in Pregnancy 19:115 (Abstract #FP-38 – presented in 1998, published in 2000).

25.    Thaete LG and Neerhof MG.  Endothelin receptor expression in uterus and placenta in two models of intrauterine growth restriction.  J Soc Gynecol Invest 6 (Suppl.):152A (Abstract #414), 1999.

26.    Thaete LG and Neerhof MG.  Endothelin receptor antagonism in L-NAME-induced hypertension in pregnant and nonpregnant rats.  Presented at the 6th International Conference on Endothelin, Montreal, Canada, October 10-13, 1999.

27.    Neerhof MG and Thaete LG.  Endothelin receptor antagonism in pregnant and nonpregnant rats: effect on blood pressure.  Presented at the 6th International Conference on Endothelin, Montreal, Canada, October 10-13, 1999.

28.    Neerhof MG, Silver RK and Thaete LG. Influence of endothelin antagonist receptor selectivity on pregnancy outcome in normal rats.  J Soc Gynecol Invest 7 (Suppl.):100A (Abstract #203), 2000.

29.    Thaete LG, Neerhof MG and Silver RK. Impact of endothelin antagonist receptor specificity on fetal growth in the nitric oxide synthase-inhibited rat.  J Soc Gynecol Invest 7 (Suppl.):100A (Abstract #204), 2000.

30.    Madsen KM, Neerhof MG and Thaete LG. Influence of ETB receptor antagonism on pregnancy outcome in normal rats.  J Soc Gynecol Invest 7 (Suppl.):100A (Abstract #205), 2000.

31.    Madsen KM, Neerhof MG and Thaete LG.  Differential impact on blood pressure and fetal growth of ETB receptor antagonism in the rat.  Hypertension in Pregnancy 19 (Suppl.):6 (Abstract #O11), 2000.

32.    Thaete LG and Neerhof MG.  Fetal growth restriction in the eNOS gene knockout mouse.  Hypertension in Pregnancy 19 (Suppl.):6 (Abstract #O12), 2000.

33.    Thaete LG, Chen S-J and Neerhof MG.  Endothelin and ischemia/reperfusion-induced intrauterine growth restriction in the rat.  J Soc Gynecol Invest 8 (Suppl.):263A (Abstract #737), 2001.

34.    Thaete LG, Chen S-J and Neerhof MG.  Contribution of endothelin to the regulation of uterine and placental blood flow during nitric oxide synthase inhibition in the pregnant rat.  Presented at the 7th International Conference on Endothelin, Edinburgh, Scotland, September 14-19, 2001.

35.    Thaete LG and Neerhof MG.  Platelet activating factor infusion restricts fetal and placental growth in the rat.  J Soc Gynecol Invest 9 (Suppl.):217A (Abstract #468), 2002.

36.    Thaete LG and Neerhof MG.  Impact over time of endothelin on fetal and placental growth during L-NAME treatment of pregnant rats.  Hypertension in Pregnancy 21 (Suppl):24 (Abstract #P003), 2002.

37.    Thaete LG and Neerhof MG.  Impact over time of endothelin receptor antagonism on uterine and placental perfusion in the L-NAME-treated pregnant rat.  Hypertension in Pregnancy 21 (Suppl):25 (Abstract #P004), 2002.

38.    Thaete LG and Neerhof MG.  Impact of endothelin receptor antagonism on nitric oxide in maternal and fetal plasma in the L-NAME-treated pregnant rat.  J Soc Gynecol Invest 10 (Suppl):152A (Abstract #187), 2003.

39.    Silver RK, Thaete LG, Morgan MW, Nybom PC and the BUN Study Group.  Evaluation of maternal whole blood proteomic patterns to identify fetal trisomy 21.  J Soc Gynecol Invest 10 (Suppl):319A (Abstract #690), 2003.

40.    Thaete LG, Jilling T and Neerhof MG.  Placental but not pulmonary ET-1 gene expression is stimulated by hypoxia in the pregnant rat.  Presented at the 8th International Conference on Endothelin, Tsukuba, Japan, November 23-26, 2003.

41.    Thaete LG and Neerhof MG.  Phospholipase A2 expression in response to nitric oxide synthase inhibition in the rat.  J Soc Gynecol. Invest 11 (Suppl):264A (Abstract #567), 2004.

42.    Thaete LG, Gontar S and Neerhof MG.  Phospholipase A2 expression in rat placenta and uterus: impact of NOS inhibition and endothelin receptor antagonism.  Hypertension in Pregnancy 23 (Suppl 1):105 (Abstract #P088), 2004.

43.    Thaete LG, Qu X, Gontar S and Neerhof MG.  Ischemia/reperfusion induces an endothelin-mediated increase in phospholipase A2-IIA in the rat uterus.  J Soc Gynecol Invest 12 (Suppl):275A (Abstract #599), 2005.

44.    Qu X-W, Thaete LG, Rozenfeld RA, Zhu Y, De Plaen IG, Caplan MS and Hsueh W.  Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: role of neuronal nitric oxide synthase.  Presented at the International Eicosanoids Conference, Beijing, China, July 4-6, 2005.

45.    Qu X-W, Thaete LG, Gontar S, Neerhof MG.  Endothelin Expression is Upregulated by Exogenous Platelet-Activating Factor in the Kidney of the Pregnant Rat.  Presented at the 9th International Conference on Endothelin, Park City, Utah, USA, September 11-14, 2005.

46.    Thaete LG, Synowiec S, Neerhof MG.  Impact of maternally administered endothelin receptor antagonism on rat pup survival and growth.  Reproductive Sciences 14 (Suppl):99A (Abstract #152), 2007.

47.    Qu X, Thaete LG, Synowiec S, Neerhof MG.  Exogenous platelet-activating factor up-regulates renal endothelin expression in the pregnant rat.  Reproductive Sciences 14 (Suppl):107A (Abstract #181), 2007.

48.    Thaete LG, Synowiec S, Neerhof MG.  Neonatal rat survival and growth following maternally administered endothelin receptor antagonism.  Presented at the 10th International Conference on Endothelin, Bergamo, Italy, September 16-19, 2007.

49.    Thaete LG, Synowiec S, Khan S, Neerhof MG.  Oxygen saturation in neonatal rats following maternally administered endothelin receptor antagonism.  Presented at the 10th International Conference on Endothelin, Bergamo, Italy, September 16-19, 2007.

50.    Thaete LG, Synowiec S, Khan S, Neerhof MG.  Impact of maternally administered endothelin receptor antagonism on neonatal oxygen saturation in the rat.  Reproductive Sciences 15 (Suppl):126A (Abstract #231), 2008.

51.    Luo K, Thaete L, Neerhof M.  Differential impact of maternal and fetal nitric oxide on pregnancy outcome in eNOS-/- and eNOS+/+ pregnant mice.  Hypertension in Pregnancy 27:667, 2008.  Presented at the 16th World Congress of the International Society for the Study of Hypertension in Pregnancy, Washington, DC, September 21-24, 2008.

52.    Neerhof M, Synowiec S, Khan S, Thaete L.  Impact of endothelin A receptor antagonist selectivity in chronic nitric oxide synthase inhibition-induced fetal growth restriction.  Hypertension in Pregnancy 27:667, 2008.  Presented at the 16th World Congress of the International Society for the Study of Hypertension in Pregnancy, Washington, DC, September 21-24, 2008.

53.    Neerhof M, Synowiec S, Khan S, Thaete L.  Chronic L-NAME administration during pregnancy does not cause irreversible endothelial dysfunction/injury.  Hypertension in Pregnancy 27:669, 2008.  Presented at the 16th World Congress of the International Society for the Study of Hypertension in Pregnancy, Washington, DC, September 21-24, 2008.

54.    Neerhof M, Khan S, Thaete L.  Rebound effect of discontinuation of ETA antagonism in chronic NOS inhibition-induced fetal growth restriction in the rat.  Hypertension in Pregnancy 27:672, 2008.  Presented at the 16th World Congress of the International Society for the Study of Hypertension in Pregnancy, Washington, DC, September 21-24, 2008.

55.    Qu X, Neerhof MG, Jilling T, Thaete LG.  TLR4 signaling is central to ischemia/reperfusion-induced fetal growth restriction in the mouse.  Reproductive Sciences 16 (Suppl):332A (Abstract #910).  Presented at the 56th Annual Meeting of the Society for Gynecologic Investigation, Glasgow, Scotland, March 18-21, 2009.

56.    Qu X, Luo K, Khan S, Neerhof MG, Thaete LG.  Uterine and placental nitric oxide synthase (NOS) activity in ischemia/reperfusion (I/R)-induced rat fetal growth restriction (FGR).  Reproductive Sciences 16 (Suppl):335A (Abstract #918).  Presented at the 56th Annual Meeting of the Society for Gynecologic Investigation, Glasgow, Scotland, March 18-21, 2009.

57.    Thaete LG, Khan S, Neerhof MG.  Rat placental vulnerability to uterine ischemia/reperfusion-induced oxidative stress.  Reproductive Sciences 16 (Suppl):338A339A (Abstract #930).  Presented at the 56th Annual Meeting of the Society for Gynecologic Investigation, Glasgow, Scotland, March 18-21, 2009.

58.    Thaete LG, Khan S, Neerhof MG.  Platelet-activating factor-induced fetal growth restriction in the rat is prevented by endothelin receptor A antagonism.  Reproductive Sciences 16 (Suppl):339A (Abstract #931).  Presented at the 56th Annual Meeting of the Society for Gynecologic Investigation, Glasgow, Scotland, March 18-21, 2009.

59.    Thaete LG, Khan S, Neerhof MG.  Endothelin receptor A antagonism prevents platelet-activating factor-induced fetal growth restriction in the rat.  Presented at the 11th International Conference on Endothelin, Montreal, Quebec, Canada, September 9-12, 2009.

60.    Qu X, Neerhof MG, Jilling T, Thaete LG.  TLR4 signaling-mediated endothelin upregulation is central to ischemia/reperfusion-induced fetal growth restriction in the mouse.  Presented at the 11th International Conference on Endothelin, Montreal, Quebec, Canada, September 9-12, 2009.

61.    Thaete LG, Khan S, Neerhof MG.  Endothelin receptor A antagonism prevents placental pathology caused by uterine ischemia/reperfusion-induced oxidative stress in the rat.  Presented at the 11th International Conference on Endothelin, Montreal, Quebec, Canada, September 9-12, 2009.

62.    Luo K, Thaete LG, Qu X, Neerhof MG.  Impact of maternal vs. fetal nitric oxide deficiency on fetal growth in eNOS gene knockout mice.  Reproductive Sciences 17 (Suppl):213A (Abstract #519).  Presented at the 57th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL , March 24-27, 2010.

63.    Luo K, Thaete LG, Qu X, Neerhof MG.  Endothelin plays a prominent role in the pathophysiology of FGR in pregnant eNOS-/- mice.  Reproductive Sciences 17 (Suppl):214A (Abstract #520).  Presented at the 57th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL , March 24-27, 2010.

64.    Thaete LG, Khan S, Neerhof MG. Endothelin expression in ischemia/reperfusion-induced fetal growth restriction in the rat. Pregnancy Hypertension1 (Suppl. 1) S50 (Abstract P30).  Presented at the 17th World Congress of the International Society for the Study of Hypertension in Pregnancy, Melbourne, Australia, October 3-6, 2010.

65.    Thaete LG, Khan S, Synowiec S, Neerhof MG.  Maternally administered endothelin receptor antagonist has limited access to the fetal compartment. Pregnancy Hypertension1 (Suppl. 1) S50 (Abstract P31).  Presented at the 17th World Congress of the International Society for the Study of Hypertension in Pregnancy, Melbourne, Australia, October 3-6, 2010.

66.    Luo K, Thaete LG, Neerhof MG.  Improved fetal weights in sequential generations in eNOS-/- mice. Pregnancy Hypertension1 (Suppl. 1) S51 (Abstract P34).  Presented at the 17th World Congress of the International Society for the Study of Hypertension in Pregnancy, Melbourne, Australia, October 3-6, 2010.

67.    Qu X-W, Neerhof MG, Jilling T, Luo K, Thaete LG.  C5-deficient mice are protected against uterine ischemia/reperfusion-induced pregnancy loss and fetal growth restriction. Reproductive Sciences 18 (Suppl):220A (Abstract F-165).  Presented at the 58th Annual Meeting of the Society for Gynecologic Investigation, Miami Beach, FL , March 16-19, 2011.

68.    Qu X-W, Khan S, Jilling T, Neerhof MG, Thaete LG.  Toll-like receptor 4 and the response to uteroplacental ischemia/reperfusion.  Reproductive Sciences 18 (Suppl):338A (Abstract S-151).  Presented at the 58th Annual Meeting of the Society for Gynecologic Investigation, Miami Beach, FL , March 16-19, 2011.

69.    Luo K, Thaete LG, Qu X-W, Neerhof MG.  Endothelin receptor A antagonism prevents fetal growth restriction in pregnant eNOS-/- mice.  Presented (oral) at the 12th International Conference on Endothelin, Cambridge, UK, September 11-14, 2011.

70.    Thaete LG, Khan S, Neerhof MG.  The timing and source of endothelin expression in ischemia/reperfusion-induced fetal growth restriction in the rat.  Presented (poster) at the 12th International Conference on Endothelin, Cambridge, UK, September 11-14, 2011.

71.    Thaete LG, Khan S, Synowiec S, Neerhof MG.  Endothelin receptor antagonist has limited access to the fetal compartment during chronic maternal administration late in pregnancy.  Presented (poster) at the 12th International Conference on Endothelin, Cambridge, UK, September 11-14, 2011.

72.    Thaete LG, Levin SI, Dudley AT.  Impact of anesthetics and analgesics at defined times during gestation on fetal growth in the mouse.  Reproductive Sciences 19 (Suppl):250A (Abstract F-080).  Presented (poster) at the 59th annual meeting of the Society for Gynecologic Investigation, San Diego, CA, March 21-24, 2012.

73.    Thaete LG, Levin SI, Dudley AT.  Anesthetics and analgesics at defined times during gestation: Impact on fetal growth in the mouse.  Presented (poster) at the 2012 American College of Laboratory Animal Medicine Forum, St. Petersburg Beach, FL, May 6-9, 2012.

74.    Qu X-W, Jilling T, Neerhof MG, Hirsch E, Thaete LG.  Differential strain sensitivities to ischemia/reperfusion in two mouse models of fetal growth restriction.  Pregnancy Hypertension 2:206 (Abstract OS054).  Presented (oral) at the 18th World Congress of the International Society for the Study of Hypertension in Pregnancy, Geneva, Switzerland, July 9-12, 2012.

75.    Lee LR, Hood BL, Nguyen H, Kavandi L, Turbov JM, Thaete LG, HamiltonCA, Rodriguez GC, Maxwell GL, Conrads TP, Syed V. Calcitriol and progesterone synergistically inhibit growth in endometrial cancer cells. Proceedings of the 104th Annual Meeting of the American Association for Cancer Research 54:Abstract 1716, Washington, DC, April 6-10, 2013.

76.    Hunn J, Turbov J, Rosales R, Syed V, Hamilton CA, Maxwell GL, Thaete LG, Rodriguez GC.  Progestin and vitamin D suppress growth of ovarian cancer in vitro and in vivo.  Gynecologic Oncology 133 (Suppl 1): 110 (Abstract 273).  Presented (poster) at the 45th annual meeting of the Society of Gynecologic Oncology, Tampa, FL, March 22-25, 2014.

77.    Bokhari AA, Lee LR, Raboteau D, Hamilton CA, Maxwell GL, Turbov JM, Thaete LG, Rodriguez GC, Syed V.  Progesterone inhibits endometrial cancer growth and invasiveness by modulating the TGF-ß pathway.  Proceedings of the 105th Annual Meeting of the American Association for Cancer Research 55:Abstract 3467, San Diego, CA, April 5-9, 2014.

78.    Rodriguez GC, Turbov J, Rosales R, Syed V, Conrads TP, Darcy KM, Maxwell GL, Hamilton CA, Thaete, LG.  Progestins inhibit calcitriol-induced CYP24A1 in endometrial and ovarian cancer cells.  Gynecologic Oncology 137 (Suppl 1): 64-65 (Abstract 149).  Presented (poster) at the 46th annual meeting of the Society of Gynecologic Oncology, Chicago, IL, March 28-31, 2015.

79.    Hunn J, Turbov J, Rosales R, Syed V, Hamilton CA, Maxwell GL, Darcy KM, Thaete LG,Rodriguez GC.  Progestins and vitamin D inhibit CYP24A1 in vivo in ovarian cancer cell xenografts.  Gynecologic Oncology 137 (Suppl 1): 204 (Abstract 507).  Presented (poster) at the 46th annual meeting of the Society of Gynecologic Oncology, Chicago, IL, March 28-31, 2015.

80.    Kim JS, Turbov J, Rosales R, Thaete LG, Rodriguez GC.  Combination metformin and simvastatin treatment synergistically inhibits endometrial cancer cell growth in vitro.  Gynecologic Oncology 141 (Suppl 1): 92-93 (Abstract 224).  Presented (poster) at the 47th annual meeting of the Society of Gynecologic Oncology, San Diego, CA, March 19-22, 2016.

81.    Conrads KA, Bateman NW, Litzi T, Turbov J, Thaete LG, Rosales R, Rodriguez GC, Hamilton CA, Maxwell GL, Conrads TP.  Identification of functional progesterone response elements in the CYP24A1 promoter.  Gynecologic Oncology (Suppl 1): (Abstract 7606).  Presented (poster) at the 48th annual meeting of the Society of Gynecologic Oncology, Washington, DC, March 11-14, 2017.

82.    Rosales R, Turbov J, Yoo J, Rodriguez G, Thaete L.  Stem cell property-suppressing microRNAs are stimulated and their target proteins inhibited by vitamin D and progesterone in ovarian cancer cells.  Proceedings of the 108th Annual Meeting of the American Association for Cancer Research (Abstract 1259), Washington, DC, April 1-5, 2017.