My research interests include development of novel diagnostic assays for infectious diseases and the use of these assays for optimum patient care. Molecular methods, are significantly more sensitive and specific for early detection of infection. However, in some infections such as urinary tract infections, it is difficult to differentiate true infection from asymptomatic carriage of bacteria. As a result, patients are often treated unnecessarily with adverse events including the increase in antimicrobial resistance. Understanding the host response in pathogenesis of urinary tract infection and development of assays based on biomarkers for diagnosis is an approach that can differentiate true infection and is the focus of my research.
I also study epidemiology of multi-drug resistant bacterial infections, primarily MRSA and C. difficile. I use molecular typing methods to understand the pathogenesis and spread of these infections within the hospital.