Larry G.Thaete, PhD
Department of Obstetrics and Gynecology
Division of Maternal-Fetal Medicine
- Graduate: PhD, Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina, Charleston, SC
- Postgraduate: Lung Cancer Cell Biology Research, University of Colorado, Boulder
Honors and Awards
- (1997) Award for Research Excellence at the 17th Annual Meeting of the Society of Perinatal Obstetricians
Current: The roles of endogenous vasoactive mediators in the pathophysiology of intrauterine growth restriction. The goal of this research is to develop a means of intervention in cases of preterm growth restriction which will allow pregnancy to continue until delivery is possible.
General: The role of endogenous vasoactive mediators in the pathobiology of adverse pregnancy outcome, mechanisms of receptor regulation and function, cell and tissue ultrastructural morphology, immunocytochemistry, and histochemistry of proteins in normal and neoplastic tissues, and interactions between normal and neoplastic cells.
Authored over 30 peer-reviewed scientific papers and has made numerous scientific presentations at national and international professional meetings. He is currently principal investigator on a grant from the National Institutes of Health and has received over $1,500,000 in sponsored funds.
Publications in Peer-Review Journals:
Thaete LG, Neerhof MG, and Caplan MS. Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat. Am J Obstet Gynecol 176:73-76, 1997.
Neerhof MG, Silver RK, Caplan MS, and Thaete LG. Endothelin-1-induced placental and fetal growth restriction in the rat. J Maternal-Fetal Med 6:125-128, 1997.
Thaete LG and Neerhof MG. Endothelin and blood pressure regulation in the female rat: Studies in normal pregnancy and with nitric oxide synthase inhibition-induced hypertension. Hypertension in Pregnancy 19:233-247, 2000.
Thaete LG, Neerhof MG, and Silver RK. Differential effects of endothelin A and B receptor antagonism on fetal growth in normal and nitric oxide-deficient rats. J Soc Gynecol Invest 8:18-23, 2001.
Madsen KM, Neerhof MG, Wessale JL, and Thaete LG. Influence of ETB receptor antagonism on pregnancy outcome in rats. J Soc Gynecol Invest 8:239-244, 2001.
Thaete LG, Neerhof MG, Jilling T, and Caplan MS. Exogenous platelet-activating factor infusion produces intrauterine growth restriction in the rat. J Soc Gynecol Invest 10:145-150, 2003.
Thaete LG, Dewey ER, and Neerhof MG. Endothelin and the regulation of uterine and placental perfusion in hypoxia-induced fetal growth restriction. J Soc Gynecol Invest 11:16-21, 2004.
Thaete LG, Kushner DM, Dewey ER, and Neerhof MG. Endothelin and the regulation of uteroplacental perfusion in nitric oxide synthase inhibition-induced fetal growth restriction. Placenta 26:242-250, 2005.
Qu X-W, Thaete LG, Rozenfeld RA, Zhu Y, De Plaen IG, Caplan MS and Hsueh W. Tetrahydropiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: role of neuronal nitric oxide synthase. Crit Care Med 33:1050-1056, 2005.
Thaete LG and Neerhof MG. Endothelin and platelet-activating factor: Significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat. Am J Obstet Gynecol 194:1377-1383, 2006.
- Thaete LG, Jilling T, Synowiec S, Khan S and Neerhof MG. Expression of endothelin 1 and its receptors in the hypoxic pregnant rat. Biol Reprod 77:526-532, 2007.
- Neerhof MG, Jilling T, Synowiec S, Khan S and Thaete LG. Altered endothelin receptor binding in response to nitric oxide synthase inhibition in the pregnant rat. Reproductive Sciences 15:366-373, 2008.
- Neerhof MG and Thaete LG. The fetal response to chronic placental insufficiency. In: Intrauterine Growth Restriction (Galan HL, ed.). Seminars in Perinatology (D’Alton ME and Gross I, eds.). New York: Elsevier, 32:201-205, 2008.
- Neerhof MG, Synowiec S, Khan S and Thaete LG. Impact of endothelin A receptor antagonist selectivity in chronic nitric oxide synthase inhibition-induced fetal growth restriction in the rat. Hypertension in Pregnancy 29:284-293, 2010.
- Neerhof MG, Synowiec S, Khan S and Thaete LG. Pathophysiology of chronic nitric oxide synthase inhibition-induced fetal growth restriction in the rat. Hypertension in Pregnancy 30:28-36, 2011.