Larry G.Thaete, PhDDepartment of Obstetrics and Gynecology
Division of Gynecologic Oncology
Research Scientist II


Contact Information
847.570.2372
847.570.2910 fax
lthaete@northshore.org

Education

  • Undergraduate: BS, Zoology, College of Idaho, Caldwell
  • Graduate: MS, Biological Sciences, Northern Arizona University, Flagstaff
  • Graduate: PhD, Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina, Charleston
  • Postgraduate: Lung Cancer Cell Biology Research, University of Colorado, Boulder

Academic and Administrative Appointments

  • Research Associate (Associate Professor), Obstetrics/Gynecology, Pritzker School of Medicine, University of Chicago, Chicago, IL.
  • Chair, NorthShore University HealthSystem Animal Care and Use Committee, Evanston, IL.

Honors and Awards

  • (1997) Award for Research Excellence at the 17th Annual Meeting of the Society of Perinatal Obstetricians 

Research Interests

Current:  Prevention of ovarian and endometrial cancer.

General:  The role of endogenous vasoactive mediators in the pathobiology of adverse pregnancy outcome, mechanisms of receptor regulation and function, cell and tissue ultrastructural morphology, immunocytochemistry and histochemistry of proteins in normal and neoplastic tissues, and interaction between normal and neoplastic cells.

Career Summary

Authored over 45 peer-reviewed scientific papers and has made numerous scientific presentations at national and international professional meetings.  He conducted basic science research in Maternal Fetal Medicine for 17 years, on the development of a therapeutic regimen for fetal growth restriction.  He is now conducting basic science research on the chemoprevention of ovarian and endometrial cancer, since 2011.

Professional Memberships/Affiliations/Activities

  • American Association for Cancer Research
  • Society for Reproductive Investigation
  • International Society for the Study of Hypertension in Pregnancy
  • The Histochemical Society

Scholarly Work

Publications in Peer-Review Journals:

  1. Thaete LG, Neerhof MG and Caplan MS.  Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat.  Am J Obstet Gynecol 176:73-76, 1997.
  2. Neerhof MG, Silver RK, Caplan MS and Thaete LG.  Endothelin-1-induced placental and fetal growth restriction in the rat.  J Maternal-Fetal Med 6:125-128, 1997.
  3. Thaete LG and Neerhof MG.  Endothelin and blood pressure regulation in the female rat:  Studies in normal pregnancy and with nitric oxide synthase inhibition-induced hypertension.  Hypertension in Pregnancy 19:233-247, 2000.
  4. Thaete LG, Neerhof MG and Silver RK.  Differential effects of endothelin A and B receptor antagonism on fetal growth in normal and nitric oxide-deficient rats.  J Soc Gynecol Invest 8:18-23, 2001.
  5. Madsen KM, Neerhof MG, Wessale JL and Thaete LG.  Influence of ETB receptor antagonism on pregnancy outcome in rats.  J Soc Gynecol Invest 8:239-244, 2001.
  6. Thaete LG, Neerhof MG, Jilling T and Caplan MS.  Exogenous platelet-activating factor infusion produces intrauterine growth restriction in the rat.  J Soc Gynecol Invest 10:145-150, 2003.
  7. Thaete LG, Dewey ER and Neerhof MG.  Endothelin and the regulation of uterine and placental perfusion in hypoxia-induced fetal growth restriction.  J Soc Gynecol Invest 11:16-21, 2004.
  8. Thaete LG, Kushner DM, Dewey ER and Neerhof MG.  Endothelin and the regulation of uteroplacental perfusion in nitric oxide synthase inhibition-induced fetal growth restriction.  Placenta 26:242-250, 2005.
  9. Qu X-W, Thaete LG, Rozenfeld RA, Zhu Y, De Plaen IG, Caplan MS and Hsueh W.  Tetrahydropiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: role of neuronal nitric oxide synthase.  Crit Care Med 33:1050-1056, 2005.
  10. Thaete LG and Neerhof MG.  Endothelin and platelet-activating factor: Significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat.  Am J Obstet Gynecol 194:1377-1383, 2006.
  11. Thaete LG, Jilling T, Synowiec S, Khan S and Neerhof MG.  Expression of endothelin 1 and its receptors in the hypoxic pregnant rat.  Biol Reprod 77:526-532, 2007.
  12. Neerhof MG, Jilling T, Synowiec S, Khan S and Thaete LG.  Altered endothelin receptor binding in response to nitric oxide synthase inhibition in the pregnant rat.  Reprod Sci 15:366-373, 2008.
  13. Neerhof MG, Synowiec S, Khan S and Thaete LG.  Impact of endothelin A receptor antagonist selectivity in chronic nitric oxide synthase inhibition-induced fetal growth restriction in the rat.  Hypertens Preg 29:284-293, 2010.
  14. Neerhof MG, Synowiec S, Khan S and Thaete LG.  Pathophysiology of chronic nitric oxide synthase inhibition-induced fetal growth restriction in the rat.  Hypertens Preg 30:28-36, 2011.
  15. Rodriguez GC, Turbov JM, Berchuck A, Stack MS, Hurteau JA, Thaete LG, Barry CP.  Non-steroidal anti-inflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells.  Am J Obstet Gynecol 206:253.e1-9, 2012.
  16. Thaete LG, Khan S, Synowiec S, Dayton BD, Bauch J, Neerhof MG.  Endothelin receptor antagonist has limited access to the fetal compartment during chronic maternal administration late in pregnancy.  Life Sci 91:583-586, 2012.
  17. Neerhof MG, Khan S, Synowiec S, Qu X-W, Thaete LG.  The significance of endothelin in platelet activating factor-induced fetal growth restriction.  Reprod Sci 19:1175-1180, 2012.
  18. Qu X-W, Jilling T, Neerhof MG, Luo K, Hirsch E, Thaete LG.  Unilateral uterine ischemia/reperfusion-induced bilateral fetal loss and fetal growth restriction in a murine model require intact complement component 5.  J Reprod Immunol 95:27-35, 2012.
  19. Thaete LG, Qu X-W, Jilling T, Crawford SE, Fitchev P, Hirsch E, Khan S, Neerhof MG.  Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice.  Reproduction 145:517-526, 2013.
  20. Thaete LG, Levin SI, Dudley AT.  Impact of anaesthetics and analgesics on fetal growth in the mouse.  Lab Anim 47:175-183, 2013.
  21. Lee LR, Teng P-N, Nguyen H, Hood BL, Kavandi L, Wang G, Turbov JM, Thaete LG, Hamilton CA, Maxwell GL, Rodriguez GC, Conrads TP, Syed V.  Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.  Cancer Prev Res 6:731-743, 2013.

Book Chapters:

  1. Crouch RK and Thaete LG.  Immunolocalization of CuZn SOD.  In: CRC Handbook of Methods for Oxygen Radical Research (Greenwald RA, ed.).  Boca Raton, FL: CRC Press, p. 271-275, 1985.
  2.  Thaete LG.  Techniques for the elimination of artefacts in lead and uranium staining.  In: Procedures in Electron Microscopy (Robards AW and Wilson AJ, eds.). West Sussex, England: John Wiley & Sons, Chapter 5, Module 6, p. 34-36, 1993.
  3.  Neerhof MG and Thaete LG.  The fetal response to chronic placental insufficiency.  In:  Intrauterine Growth Restriction (Galan HL, ed.).  Seminars in Perinatology (D’Alton ME and Gross I, eds.). New York: Elsevier, 32:201-205, 2008.

Peer Review Service:

Peer reviewer for various scientific journals, including:

  • American Journal of Obstetrics & Gynecology
  • Placenta
  • Reproduction
  • Reproduction, Fertility and Development
  • European Journal of Obstetrics, Gynecology and Reproductive Biology
  • International Journal of Gynecology & Obstetrics
  • Journal of Obstetrics & Gynaecology Research
  • Current Pediatric Reviews
  • Neonatology
  • American Journal of Pathology
  • American Journal of Physiology
  • Journal of Physiology and Pharmacology
  • Canadian Journal of Physiology and Pharmacology
  • American Journal of Hypertension
  • Journal of Endocrinology
  • Molecular and Cellular Endocrinology
  • Free Radical Biology & Medicine
  • African Journal of Biotechnology
  • Anesthesia & Analgesia
  • Medical Science Monitor
  • Mini-Reviews in Medicinal Chemistry

Presentations: (Selected from over 75 presentations)

  1. Thaete LG, Magnuson SR and Neerhof MG. Uterine and placental endothelin (ET-1) receptor subtypes in the rat: Relationship to fetal and placental growth and organ perfusion.  Am J Obstet Gynecol 174:384 (Abstract #266), 1996.
  2. Thaete LG, Neerhof MG, Silver RK, Caplan MS and Brodin AG. Chronic endothelin infusion in the pregnant rat: Hemodynamic, biochemical, and placental histologic effects.  Am J Obstet Gynecol 174:386 (Abstract #275), 1996.
  3. Thaete LG and Neerhof MG. Endothelin subtype A receptor antagonism normalizes hypoxia-induced intrauterine growth restriction. J Soc Gynecol Invest 3:62A (Abstract #8), 1996.
  4. Thaete LG and Neerhof MG. Endothelin at pathophysiologic serum levels produces intrauterine growth restriction in the absence of maternal hypertension in the rat.  Hypertension in Pregnancy 16:88 (presented in 1996, published in 1997).
  5. Thaete LG, Neerhof MG, Gosnell ER and Kushner DM.  Placental perfusion is decreased in a dose-dependent fashion in chronic NOS-inhibition-induced IUGR.  Am J Obstet Gynecol 176:S164 (Abstract #569), 1997.
  6. Neerhof MG and Thaete LG.  The contribution of endothelin to the regulation of maternal blood pressure in the pregnant rat: observations with and without chronic nitric oxide synthase inhibition.  J Soc Gynecol Invest 5 (Suppl.):68A (Abstract #114), 1998.
  7. Thaete LG and Neerhof MG.  Endothelin receptor antagonism in L-NAME-induced hypertension in pregnant and nonpregnant rats.  Presented at the 6th International Conference on Endothelin, Montreal, Canada, October 10-13, 1999.
  8. Thaete LG, Neerhof MG and Silver RK. Impact of endothelin antagonist receptor specificity on fetal growth in the nitric oxide synthase-inhibited rat.  J Soc Gynecol Invest 7 (Suppl.):100A (Abstract #204), 2000.
  9. Madsen KM, Neerhof MG and Thaete LG.  Differential impact on blood pressure and fetal growth of ETB receptor antagonism in the rat.  Hypertension in Pregnancy 19 (Suppl.):6 (Abstract #O11), 2000.
  10. Thaete LG and Neerhof MG.  Fetal growth restriction in the eNOS gene knockout mouse.  Hypertension in Pregnancy 19 (Suppl.):6 (Abstract #O12), 2000.
  11. Thaete LG, Chen S-J and Neerhof MG.  Endothelin and ischemia/reperfusion-induced intrauterine growth restriction in the rat.  J Soc Gynecol Invest 8 (Suppl.):263A (Abstract #737), 2001.
  12. Thaete LG, Chen S-J and Neerhof MG.  Contribution of endothelin to the regulation of uterine and placental blood flow during nitric oxide synthase inhibition in the pregnant rat.  Presented at the 7th International Conference on Endothelin, Edinburgh, Scotland, September 14-19, 2001.
  13. Thaete LG and Neerhof MG.  Platelet activating factor infusion restricts fetal and placental growth in the rat.  J Soc Gynecol Invest 9 (Suppl.):217A (Abstract #468), 2002.
  14. Thaete LG and Neerhof MG.  Impact over time of endothelin receptor antagonism on uterine and placental perfusion in the L-NAME-treated pregnant rat.  Hypertension in Pregnancy 21 (Suppl):25 (Abstract #P004), 2002.
  15. Silver RK, Thaete LG, Morgan MW, Nybom PC and the BUN Study Group.  Evaluation of maternal whole blood proteomic patterns to identify fetal trisomy 21.  J Soc Gynecol Invest 10 (Suppl):319A (Abstract #690), 2003.
  16. Thaete LG, Jilling T and Neerhof MG.  Placental but not pulmonary ET-1 gene expression is stimulated by hypoxia in the pregnant rat.  Presented at the 8th International Conference on Endothelin, Tsukuba, Japan, November 23-26, 2003.
  17. Thaete LG, Gontar S and Neerhof MG.  Phospholipase A2 expression in rat placenta and uterus: impact of NOS inhibition and endothelin receptor antagonism.  Hypertension in Pregnancy 23 (Suppl 1):105 (Abstract #P088), 2004.
  18. Thaete LG, Qu X, Gontar S and Neerhof MG.  Ischemia/reperfusion induces an endothelin-mediated increase in phospholipase A2-IIA in the rat uterus.  J Soc Gynecol Invest 12 (Suppl):275A (Abstract #599), 2005.
  19. Qu X-W, Thaete LG, Rozenfeld RA, Zhu Y, De Plaen IG, Caplan MS and Hsueh W.  Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: role of neuronal nitric oxide synthase.  Presented at the International Eicosanoids Conference, Beijing, China, July 4-6, 2005.
  20. Thaete LG, Synowiec S, Neerhof MG.  Impact of maternally administered endothelin receptor antagonism on rat pup survival and growth.  Reproductive Sciences 14 (Suppl):99A (Abstract #152), 2007.
  21. Qu X, Thaete LG, Synowiec S, Neerhof MG.  Exogenous platelet-activating factor up-regulates renal endothelin expression in the pregnant rat.  Reproductive Sciences 14 (Suppl):107A (Abstract #181), 2007.
  22. Thaete LG, Synowiec S, Neerhof MG.  Neonatal rat survival and growth following maternally administered endothelin receptor antagonism.  Presented at the 10th International Conference on Endothelin, Bergamo, Italy, September 16-19, 2007.
  23. Thaete LG, Synowiec S, Khan S, Neerhof MG.  Impact of maternally administered endothelin receptor antagonism on neonatal oxygen saturation in the rat.  Reproductive Sciences 15 (Suppl):126A (Abstract #231), 2008.
  24. Luo K, Thaete L, Neerhof M.  Differential impact of maternal and fetal nitric oxide on pregnancy outcome in eNOS-/- and eNOS+/+ pregnant mice.  Hypertension in Pregnancy 27:667, 2008.  Presented at the 16th World Congress of the International Society for the Study of Hypertension in Pregnancy, Washington, DC, September 21-24, 2008.
  25. Neerhof M, Synowiec S, Khan S, Thaete L.  Impact of endothelin A receptor antagonist selectivity in chronic nitric oxide synthase inhibition-induced fetal growth restriction.  Hypertension in Pregnancy 27:667, 2008.  Presented at the 16th World Congress of the International Society for the Study of Hypertension in Pregnancy, Washington, DC, September 21-24, 2008.
  26. Neerhof M, Synowiec S, Khan S, Thaete L.  Chronic L-NAME administration during pregnancy does not cause irreversible endothelial dysfunction/injury.  Hypertension in Pregnancy 27:669, 2008.  Presented at the 16th World Congress of the International Society for the Study of Hypertension in Pregnancy, Washington, DC, September 21-24, 2008.
  27. Neerhof M, Khan S, Thaete L.  Rebound effect of discontinuation of ETA antagonism in chronic NOS inhibition-induced fetal growth restriction in the rat.  Hypertension in Pregnancy 27:672, 2008.  Presented at the 16th World Congress of the International Society for the Study of Hypertension in Pregnancy, Washington, DC, September 21-24, 2008.
  28. Qu X, Neerhof MG, Jilling T, Thaete LG.  TLR4 signaling is central to ischemia/reperfusion-induced fetal growth restriction in the mouse.  Reproductive Sciences 16 (Suppl):332A (Abstract #910).  Presented at the 56th Annual Meeting of the Society for Gynecologic Investigation, Glasgow, Scotland, March 18-21, 2009.
  29. Thaete LG, Khan S, Neerhof MG.  Platelet-activating factor-induced fetal growth restriction in the rat is prevented by endothelin receptor A antagonism.  Reproductive Sciences 16 (Suppl):339A (Abstract #931).  Presented at the 56th Annual Meeting of the Society for Gynecologic Investigation, Glasgow, Scotland, March 18-21, 2009.
  30. Thaete LG, Khan S, Neerhof MG.  Endothelin receptor A antagonism prevents placental pathology caused by uterine ischemia/reperfusion-induced oxidative stress in the rat.  Presented at the 11th International Conference on Endothelin, Montreal, Quebec, Canada, September 9-12, 2009.
  31. Luo K, Thaete LG, Qu X, Neerhof MG.  Impact of maternal vs. fetal nitric oxide deficiency on fetal growth in eNOS gene knockout mice.  Reproductive Sciences 17 (Suppl):213A (Abstract #519).  Presented at the 57th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL , March 24-27, 2010.
  32. Thaete LG, Khan S, Synowiec S, Neerhof MG.  Maternally administered endothelin receptor antagonist has limited access to the fetal compartment. Pregnancy Hypertension 1 (Suppl. 1) S50 (Abstract P31).  Presented at the 17th World Congress of the International Society for the Study of Hypertension in Pregnancy, Melbourne, Australia, October 3-6, 2010.
  33. Qu X-W, Neerhof MG, Jilling T, Luo K, Thaete LG.  C5-deficient mice are protected against uterine ischemia/reperfusion-induced pregnancy loss and fetal growth restriction. Reproductive Sciences 18 (Suppl):220A (Abstract F-165).  Presented at the 58th Annual Meeting of the Society for Gynecologic Investigation, Miami Beach, FL , March 16-19, 2011.
  34. Qu X-W, Khan S, Jilling T, Neerhof MG, Thaete LG.  Toll-like receptor 4 and the response to uteroplacental ischemia/reperfusion.  Reproductive Sciences 18 (Suppl):338A (Abstract S-151).  Presented at the 58th Annual Meeting of the Society for Gynecologic Investigation, Miami Beach, FL , March 16-19, 2011.
  35. Luo K, Thaete LG, Qu X-W, Neerhof MG.  Endothelin receptor A antagonism prevents fetal growth restriction in pregnant eNOS-/- mice.  Presented (oral) at the 12th International Conference on Endothelin, Cambridge, UK, September 11-14, 2011.
  36. Thaete LG, Levin SI, Dudley AT.  Impact of anesthetics and analgesics at defined times during gestation on fetal growth in the mouse.  Reproductive Sciences 19 (Suppl):250A (Abstract F-080).  Presented (poster) at the 59th annual meeting of the Society for Gynecologic Investigation, San Diego, CA, March 21-24, 2012.
  37. Qu X-W, Jilling T, Neerhof MG, Hirsch E, Thaete LG.  Differential strain sensitivities to ischemia/reperfusion in two mouse models of fetal growth restriction.  Pregnancy Hypertension 2:206 (Abstract OS054).  Presented (oral) at the 18th World Congress of the International Society for the Study of Hypertension in Pregnancy, Geneva, Switzerland, July 9-12, 2012.
  38. Lee LR, Hood BL, Nguyen H, Kavandi L, Turbov JM, Thaete LG, Hamilton CA, Rodriguez GC, Maxwell GL, Conrads TP, Syed V. Calcitriol and progesterone synergistically inhibit growth in endometrial cancer cells. Proceedings of the 104th Annual Meeting of the American Association for Cancer Research 54:Abstract 1716, Washington, DC, April 6-10, 2013.
  39. Hunn J, Turbov J, Rosales R, Syed V, Hamilton CA, Maxwell GL, Thaete LG, Rodriguez GC.  Progestin and vitamin D suppress growth of ovarian cancer in vitro and in vivo.  Presented (poster) at the annual meeting of the Society of Gynecologic Oncology, Tampa, FL, March 22-25, 2014.
  40. Bokhari AA, Lee LR, Raboteau D, Hamilton CA, Maxwell GL, Turbov JM, Thaete LG, Rodriguez GC, Syed V.  Progesterone inhibits endometrial cancer growth and invasiveness by modulating the TGF-ß pathway.  Proceedings of the 105th Annual Meeting of the American Association for Cancer Research 55:Abstract 3467, San Diego, CA, April 5-9, 2014.

“Role of Endothelin in Intrauterine Growth Restriction,” PI: LG Thaete.  National Institute of Child Health and Human Development (R29 HD34777), NIH; $350,000; 2/1/98-1/31/04.

 “Impact of Endothelin in Intrauterine Growth Restriction,” PI: LG Thaete.  National Institute of Child Health and Human Development (K02 HD01484), NIH; $382,770; 6/18/01-5/31/06.

 “ET and PAF Synergism in Intrauterine Growth Restriction,” PI: LG Thaete.  National Institute of Child Health and Human Development (R01 HD042581), NIH; $832,500; 2/1/04-11/30/08.

 “Impact of Anesthesia and Analgesia on Fetal Growth in the Mouse,” PI: LG Thaete.  American College of Laboratory Animal Medicine (ACLAM) Foundation and Abbott Laboratories; $30,000; 7/2/10-12/01/11. 

Grants:

  • “Role of Endothelin in Intrauterine Growth Restriction,” PI: LG Thaete.  National Institute of Child Health and Human Development (R29 HD34777), NIH; $350,000; 2/1/98-1/31/04.
  •  “Impact of Endothelin in Intrauterine Growth Restriction,” PI: LG Thaete.  National Institute of Child Health and Human Development (K02 HD01484), NIH; $382,770; 6/18/01-5/31/06.
  •  “ET and PAF Synergism in Intrauterine Growth Restriction,” PI: LG Thaete.  National Institute of Child Health and Human Development (R01 HD042581), NIH; $832,500; 2/1/04-11/30/08.
  • “Impact of Anesthesia and Analgesia on Fetal Growth in the Mouse,” PI: LG Thaete. American College of Laboratory Animal Medicine (ACLAM) Foundation and Abbott Laboratories; $30,000; 7/2/10-12/01/11.
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