Lu-Ping Li, PhDDepartment of Radiology
Research Assistant Professor

Contact Information

847.570.1948
847.570.2942 fax
lli2@northshore.org

Education

  • Undergraduate: Department of Automation Science and Technology, School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China
  • Medical School: Department of Aerospace Aviation Physiology, School of Aerospace Medicine, Fourth Military Medical University, Xi’an, China
  • Post-Graduate: Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
  • Fellowship: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Research Interests

My main research interest in Center for Advanced Imaging has been in studying non-invasive MRI biomarkers for early diagnosis and monitoring the progression of kidney diseases such as acute renal failure, chronic kidney disease, and nephropathy associated with hypertension, diabetes and iodinated contrast administration in both human subjects and pre-clinical models by applying functional MRI techniques, particularly blood oxygenation level dependent (BOLD) MRI to evaluate the renal hypoxia which is believed to play an important role in the pathogenesis of the above diseases and conditions. I am also interested in studies of applying other functional imaging techniques, for example diffusion to assess kidney tissue microstructure which is associated with renal fibrosis, a progressive process that ultimately leads to end-stage renal failure.

Academic and Administrative Appointments

  • Research Associate, Feinberg School of Medicine, Northwestern University
  • Research Assistant Professor, Pritzker School of Medicine, The University of Chicago

Professional Memberships/Affiliations/Activities

  • Member of International Society for Magnetic Resource in Medicine (since 1998)
  • Member of the Society of Clinical Research Associates (since 2013 )

Scholarly Work  

Publications in Peer-Review Journals: (total 31 papers related to renal MRI)

  1. Lu-Ping Li, Pippa Storey, David Kim, Wei Li, and Pottumarthi Prasad. Kidney in hypertensive rats show reduced response to nitric oxide synthase inhibition as evaluated by BOLD MRI. JMRI 17:671-675(2003).
  2. Lu-Ping Li, Pippa Storey, Linda Pierchala, Wei Li, Jason Polzin*, and Pottumarthi Prasad. Evaluation of Reproducibility of Intra-renal R2* Measurements, and DR2* Measurements following administration of Furosemide and During Waterload. JMRI. 19:610-616 (2004).
  3. Lu-Ping Li, Anthony T. Vu, Belinda S.Y. Li Eugene Dunkle and Pottumarthi V. Prasad. Evaluation of intra-renal oxygenation by BOLD MRI at 3.0T. JMRI. 20:901-904 (2004).
  4. Lu-Ping Li, Laura Fogelson, Belinda S.Y. Li, Pippa Storey, Wei Li and Pottumarthi V. Prasad. Effect of free radicals scavenger (Tempol) on renal hemodynamics evaluated by BOLD MRI: A noninvasive technique toward human study. JMRI. 21:245-248 (2005).
  5. Santosh Tumkur, Anthony T. Vu, Lu-Ping Li, Pottumarthi V. Prasad. Evaluation of Intrarenal Oxygenation at 3.0 T Using 3-Dimensional Multiple Gradient-Recalled Echo Sequence. Invest Radiol. 2006 Feb;41(2):181-184.
  6. Tumkur SM, VU AT, Lu-Ping Li, Pierchala L, Prasad PV:  Evaluation of Intra-Renal Oxygenation During Water Diuresis: A Time-Resolved Study Using BOLD MRI.  Kidney Int 2006 July; 70(1): 139-43.
  7. Lu-Ping Li, Lin Ji, Scott Lindsay and Pottumarthi V. Prasad. Evaluation of Intra-Renal Oxygenation in Mice by BOLD MRI at 3.0T Human Whole Body Scanner. JMRI. 2007 Mar;25(3):635-8.
  8. Elisabete Santos, Lu-Ping Li, Lin Ji, and Pottumarthi V. Prasad. Early changes with diabetes in renal medullary hemodynamics as evaluated by fiber-optic probes & BOLD MRI. Investigative Radiology. 2007 Mar;42(3):157-62.
  9. Lu-Ping Li, Ji Lin, Elisabete A. Santos, Eugene Dunkle, Linda Pierchala and Pottumarthi Prasad, “Effect of NOS inhibition on intra-renal oxygenation in rats and human by Oxylite/Oxyflo & BOLD MRI” . Invest Radiol. 2009 Feb: 44(2): 67-73.
  10. Lin Ji, Lu-Ping Li (co-1st author), Thomas Schnitzer, Hongyan Du, and Pottumarthi V. Prasad. Intra-Renal Oxygenation in Rat Kidneys During Water-loading: Effects of COX Inhibition & NO Donation” J. Magn. Reson. Imaging 2010;32:383–387. PMID:
  11. Pottumarthi Prasad, Lu-Ping Li, Sarah Halter, JoAnn Cabray, Minghao Ye,  and Daniel Batlle. Evaluation of renal hypoxia in diabetic mice by BOLD MRI” Invest Radiol. 2010 Dec;45(12):819-22.
  12. Pippa Storey, Lin Ji, Lu-Ping Li, Pottumarthi V. Prasad. Sensitivity of USPIO-enhanced R2 imaging to dynamic blood volume changes in the rat kidney. J Magn Reson Imaging. 2011 May;33(5):1091-9.
  13. Lu-Ping Li, Tammy Franklin, Hongyan Du, Maria Papadopulou-Rosenzweig, Joann Carbray, Richard Solomon, and Pottumarthi V. Prasad. Intra-Renal Oxygenation by BOLD MRI in Contrast Nephropathy Model: Effect of the Viscosity and Dose. J Magn Reson Imaging, 2012, 2012;36:1162–1167.
  14. Lu-Ping Li, Jing Lu, Ying Zhou, Maria Papadopoulou, Tammy Franklin, Ujala Bokhary, Richard Solomon, Anindya Sen, and Pottumarthi Prasad. Evaluation of Intra-renal Oxygenation in Iodinated Contrast Induced Acute Kidney Injury (CIAKI) Susceptible Rats by BOLD MRI. Invest Radiol 2014;49: 403-410.
  15. Lu-Ping Li, Jon Thacke, Jing Lu,Tammy Franklin, Ying Zhou, Maria Papadopoulou, Richard Solomon, and Pottumarthi V. Prasad. Efficacy of Preventive Interventions for Iodinated Contrast-Induced Acute Kidney Injury (CIAKI) Evaluated by Intra Renal Oxygenation as an Early Marker. Invest Radiol. 2014 May 27. [Epub ahead of print].

Book Chapters:

  1. Lu-Ping Li, Sarah Halter, and Pottumarthi V. Prasad, Chapter “BOLD MRI of the Kidneys” in Magnetic Resonance Imaging Clinics of North America. 16(4): 613-625, November, 2008, Published by Elsevier.  
  2. Lu-Ping Li, Pottumarthi V. Prasad, Chapter “Estimation of kidney oxygenation by BOLD-MRI”, in Oxidative Stress in Applied Basic Research and Clinical Practice ‘Renal Disorders’. Published by The Humana Press / Springer Science, Editor Toshio Miyata, MD, PhD. 2011, page: 587-609.

Peer Review Service:

  • PLOS ONE
  • International Society for Magnetic Resonance in Medicine
  • Journal of Magnetic Resonance Imaging
  • Kidney International
  • Marine Drugs

Presentations (I am the first author for 15 oral presentations):

  1. M.S.Albert, A.K.Venkatesh, Lu-Ping Li, C-L Chin. D.Balamore, F.A.Jolesz. Dynamic uptake of hyperpolarized 129Xe in the rat brian. European Radiology: Hyperpolarized gases in magnetic resonance biomedical investigations and clinical application. International workshop. Les Houches, Frances, June 21-25, 1999. B41.
  2. D.C.Bloomgarden, P.Storey, W.Li, M.Zhang, Lu-Ping Li, P.Prasad, R.Edelman. How good is qualitative analysis of 1st pass Gd-DTPA multislice myocardial perfusion imaging for clinical evaluation? Presented at North American Society of Cardiac Imaging. Nov. 6 1999.
  3. D.C.Bloomgarden, P.Storey, W.Li, M.Zhang, Lu-Ping Li, P.Prasad, R.Edelman. How good is qualitative analysis of 1st pass Gd-DTPA multislice myocardial perfusion imaging for clinical evaluation? Proc. Intl. Soc. Mag. Reson. Med. 8 (2000): 1564.
  4. D.C.Bloomgarden, P.Storey, W.Li, M.Zhang, Lu-Ping Li, P.Prasad, R.Edelman. How good is qualitative analysis of 1st pass Gd-DTPA multislice myocardial perfusion imaging for clinical evaluation? Presented at Society of Cardiovascular MR, January 21, 2000.
  5. Pippa Storey, Ming Zhang, Wei Li, Daniel Bloomgarden, Lu-Ping Li, Robert Edelman and Pottumarthi Prasad, "Compensation for coil sensitivity inhomogeneities in cardiac perfusion imaging" Proc. Intl. Soc. Mag. Reson. Med. 8 (2000): 1562.
  6. M. Zhang, Lu-Ping. Li, P. Story, W. Li, D. Bloomgarden, R.Edelman and P.Prasad. "Preliminary validation of Semi-) quantitative assessment of dynamic contrast-enhanced myocardical perfusion imaging in patients with multi-vessel coronary artery disease" Proc. Intl. Soc. Mag. Reson. Med. 8 (2000):730.
  7. Lu-Ping Li, Jason Polzin*, Linda Pierchala, Pippa Storey, Wei Li, Linda Odom# and Pottumarthi Prasad. "evaluation of reproducibility of response to waterload on intrarenal oxygenation as evaluated by BOLD MRI". Proc. Intl. Soc. Mag. Reson. Med. 10(2002) Hawaii, USA. P. 808.
  8. Lu-Ping Li, David Y. Kim†, Pippa Storey, Wei Li, and Pottumarthi V. Prasad. "Effect of hypertension on renal medullary oxygenation as evaluated by BOLD MRI" Abstract. Proc. Intl. Soc. Mag. Reson. Med. 10(2002) Hawaii, USA. P. 805.
  9. Lu-Ping Li, Pippa Storey, Wei Li and Pottumarthi V. Prasad. BOLD MRI applied to study renal medullary hypoxia. Biomedical Imaging Research Opportunities Workshop. January (2003). Hyatt Regency, Bethesda. USA.
  10. Lu-Ping Li, Tony Vu, Wei Li and Pottumarthi Prasad. Renal BOLD MRI at 3.0T. Abstract. Proc. Intl. Soc. Mag. Reson. Med. 11(2003) Toronto, Canada. P170.
  11. Lu-Ping Li, Laura Fogelson, Belinda S. Li*, Wei Li, Pippa Storey and Pottumarthi Prasad. Effect of Oxygen Free Radical Scavenger on Renal Medullary Oxygenation in Hypertensive Rats as Evaluated by BOLD MRI. Abstract. Proc. Intl. Soc. Mag. Reson. Med. 11(2003), Toronto, Canada. P49.
  12. Lu-Ping Li, Pippa Storey, Eugene Dunkle, Linda Pierchala and Pottumarthi Prasad. BOLD MRI at 3.0T: Applied to intra-renal oxygenation. Proc. of Radiological Society of North America, Chicago, 2003 (89): P298.
  13. Lu-Ping Li, Engene Dunkle, Linda Pierchala and Pottomuthi V. Prasad. Effect of Nitric Oxide Inhibitor on Intra-Renal R2* Measurements in Humans. Proc. of ISMRM 2004 (12): 565. Tokyo, Japan.
  14. Lu-Ping Li, Belinda S. Li, Eugene Dunkle, Linda Pierchala and Pottomuthi V. Prasad. Intra-Renal BOLD MRI at 3.0T: Evaluation of Voxel Size Dependence and Utility of ASSET. Proc. of ISMRM 2004 (12): 562. Tokyo, Japan.
  15. Lu-Ping Li, Eugene Dunkle, Linda Pierchala and Pottumarthi Prasad. Effect of nitric oxide inhibition on intra-renal oxygenation in humans by BOLD MRI. RSNA 2004 (384-385), Chicago.
  16. Santosh Tumkur, Anthony T. Vu, Lu-Ping Li, Pottumarthi V. Prasad. Preliminary evaluation of 3D mGRE sequence for renal BOLD MRI at 3.0T. Proc. Intl. Soc. Mag. Reson. Med. 2005 (13): 560. Miami, USA.
  17. Lu-Ping Li, Lin Ji, Elizabete Santos, Linda Pierchala, Eugene Dunkle, Laura Fogelson and Pottumarthi V. Prasad. Effect of NOS inhibition by L-NAME on intra-renal BOLD MRI: dose response in rat and human kidneys. Proc. Intl. Soc. Mag. Reson. Med. 2005 (13): 559. Miami, USA.
  18. Santosh Tumkur, Anthony T. Vu, Lu-Ping Li, Pottumarthi V. Prasad. Evaluation of Intrarenal Oxygenation at 3.0 T Using 3D mGRE sequence. RSNA 2005, Chicago.
  19. Elisabete Santos, Lu-Ping Li, Lin Ji and Pottumarthi Prasad. Renal hypoxia very early in diabetes: evaluation by BOLD MRI and Oxyliet/Oxyflo probes. Biomedical Imaging Research Opportunities IV Workshop (BIROW) 2006: February 24 - 25, 2006, Bethesda North Marriott Hotel & Conference Center, Bethesda, MD.
  20. Pippa Storey, Lin Ji, Lu-Ping Li, and Pottumarthi Prasad. Detection of blood volume changes in the rat kidney using intravascular USPIO contrast agent. Proc. of ISMRM 2006 (14): 1812. Seattle, USA. May 6-12, 2006.
  21. Elisabete Santos, Lu-Ping Li, Lin Ji and Pottumarthi Prasad. Diabetic Rat Kidneys Show Enhanced Renal Hypoxia as Evaluated by BOLD MRI and Invasive pO2 and Blood Flow Probes. Proc. of ISMRM 2006 (14): 2241. Seattle, USA. May 6-12, 2006.
  22. Lu-Ping Li, Ji Lin, Scott Lindsay and Pottumarthi V. Prasad. Evaluation of Intra-Renal Oxygenation in Mice by BOLD MRI at 3.0T Human Whole Body Scanner. Proc. of ISMRM 2006 (14): 3319. Seattle, USA. May 6-12, 2006.
  23. Santosh Tumkur, Anthony Vu, Lu-Ping Li, Linda Pierchala, Pottumarthi Prasad. Evaluation of Intra-Renal Oxygenation During Water Diuresis: A Time Resolved Study Using BOLD MRI. Proc. of ISMRM 2006 (14): 3320. Seattle, USA. May 6-12, 2006.
  24. Lu-Ping Li, Andres Carillo, Eric T. Han, Eugene Dunkle, Wi Li, Sandeep N Gupta, and Pottumarthi V. Prasad. Measurement of Filtration Fraction using 2D Look-Locker Technique in Humans at 3.0T. Proc. of ISMRM 2007 (15): 405. Berlin, Germany. May 19-25, 2007.
  25. Lin Ji , Lu-Ping Li, Schnitzer T, and Prasad PV. Comparison of effects of naproxen and naproxcinod on intra-renal oxygenation during water-loading as evaluated by BOLD MRI. Proc. of ISMRM 2007 (15): 3051. Berlin, Germany. May 19-25, 2007.
  26. Pippa Storey, Ji Lin, Lu-Ping Li, Pottumarthi Prasad. Renal R2 change and dynamic kidney size variations in response to vasoactive substances in the rat. Proc. of ISMRM 2007 (15): 3049. Berlin, Germany. May 19-25, 2007.
  27. Lu-Ping Li, JoAnn Carbray, Pottumarthi Prasad. Effect of Acute Hyperglycemia on Intra-Renal Oxygenation as Estimated by BOLD MRI in Rats. Proc. ISMRM 2008 (16): 2692. Toronto, Canada. May 3-9, 2008.
  28. Pottumarthi Prasad, A. Ivanishev, R. Greenman, Lu-Ping Li, Ying Wu, JoAnn Carbray, J. Stainsby, A. Carrillo, and R. E. Lenkinski. 23Na MRI of In vivo Rat Kidneys at 3.0 T: Preliminary Experience. Proc. ISMRM 2008 (16): 2607. Toronto, Canada. May 3-9, 2008.
  29. L-P. Li, J. Carbray, S. Halter, and P. V. Prasad, Effect of Acute Hyperglycemia with Octreotide on Intra-Renal Oxygenation as Estimated by BOLD MRI in Rats. Proc. Intl. Soc. Mag. Reson. Med. 17 (2009) 4140. Hawaii, April 18-24, 2009.
  30. L-P. Li, S. Halter, J. Cabray, and P. V. Prasad, Evaluation of intra-renal oxygenation in db/db mice by BOLD MRI. Proc. Intl. Soc. Mag. Reson. Med. 17 (2009) 4109, Hawaii, April 18-24, 2009.
  31. Lu-Ping Li, Joann Carbray, Maria Papadopulou-Rosenzweig#, Richard Solomon*, and Pottumarthi V. Prasad. "Effect of Iodixanol, a Iso-osmolar Radio-Contrast Agent on Intra-Renal Oxygenation by BOLD MRI" . Proc. Intl. Soc. Mag. Reson. Med. 18 (2010) 328.
  32. Lu-Ping Li, Ph.D., Joann Carbray, BS., and Pottumarthi V. Prasad, Ph.D. "Effect of Octreotide on Intra-Renal Oxygenation as Estimated by BOLD MRI in Rats" ISMRM 2010 annual meeting. Proc. Intl. Soc. Mag. Reson. Med. 18 (2010) 4682.
  33. Lu-Ping Li, Federico Mordini, Sarah Halter, Eugene Dunkle, JoAnn Carbray, Ewa Gliwa, Hongyan Du, and Pottumarthi Prasad. Evaluation of Intra-Renal Oxygenation by BOLD MRI During Water Diuresis: Race Differences. Proc. Intl. Soc. Mag. Reson. Med. 19 (2011) 2956.
  34. Lu-Ping Li, Tammy Franklin, Joann Carbray, Maria Papadopulou-Rosenzweig, Richard Solomon, and Pottumarthi V. Prasad. Intra-Renal Oxygenation in Radio-contrast Nephropathy Model by BOLD MRI: Effect of the Dose and Viscosity. Proc. Intl. Soc. Mag. Reson. Med. 19 (2011) 440.
  35. Lu-Ping Li, Tammy Franklin, Ujala Bokhary, Maria Papadopulou-Rosenzweig, Richard Solomon, Hongyan Du, and Pottumarthi V. Prasad. Intra-Renal Oxygenation in Radio-contrast Nephropathy Model by BOLD MRI: Comparison of Contrast Media. Contrast Media Research (CMR) at Hotel Galvez in Galveston, Texas, USA, on October 30th through November 1, 2011. http://radiology.utmb.edu/CMR/CMR_Home.asp. Presented as e-poster.
  36. Pottumarthi V. Prasad, Muhammad Haque, Lu-Ping Li, Ujala Bokhary, Rajiv Agarwal, Stuart Sprague. Blood Oxygenation Level Dependent MRI in Chronic Kidney Disease: A Preliminary Cross-Sectional Study. The American Society of Nephrology, Kidney Week 2011 Annual Meeting, Session: Chronic Kidney Disease and Its Complications, November 11, 2011, Philadelphia, PA, USA.
  37. Anindya Sen, Lu-Ping Li, Ujala Bokhary, Ioannis Koktzoglou and Pottumarthi Prasad. Histogram analysis to evaluate changes on parametric maps: preliminary application to renal BOLD MRI. Proc. Intl. Soc. Mag. Reson. Med. (2012) 4066.
  38. Pottumarthi V. Prasad, Lu-Ping Li, Muhammad Haque, Anindya Sen, Ujala Bokhary, Rajiv Agarwal1 and Stuart Sprague. Quantitative Multi-parametric MRI Evaluation of Kidneys in Subjects with CKD. Selected presenting in the combined Body/MSK Study Group Lounge in 2012 ISMRM meeting. Proc. Intl. Soc. Mag. Reson. Med. (2012) 4067.
  39. Lu-Ping Li, Hongyan Du, Tammy Franklin, Ujala Bokhary, Maria Papadopulou-Rosenzweig, Richard Solomon, and Pottumarthi V. Prasad. Intra-Renal Oxygenation in Contrast Induced Nephropathy Model by BOLD MRI: Comparison of Four Radio-Contrast Agents. Proc. Intl. Soc. Mag. Reson. Med. (2012) 4073.
  40. Lu-Ping Li, Hongyu An, Tammy Franklin, Anindya Sen, Ujala Bokhary, and Pottumarthi V. Prasad. Intra-renal oxygenation by BOLD MRI in Rat Model of Contrast Induced Nephropathy (CIN): Comparing R2* and R2'. Proc. Intl. Soc. Mag. Reson. Med. (2012): 4063.
  41. Lu-Ping Li, Jon Thacker, Tammy Franklin, Hongyan Du, Anindya Sen, Maria Papadopulou-Rosenzweig, Richard Solomon, and Pottumarthi V. Prasad. Intra-Renal Oxygenation Measurement by BOLD MRI in Contrast Induced Nephropathy Model: Effect of Interventions. 2013 ISMRM annual meeting, Salt Lake City, UT, USA. Proc. Intl. Soc. Mag. Reson. Med. 21 (2013) 4135.
  42. Lu-Ping Li, Jing Lu, Tammy Franklin, Jon Thacker, Maria Papadopulou-Rosenzweig, Richard Solomon, Ying Zhou, and Pottumarthi V. Prasad. Intra-Renal Oxygenation in Radio-contrast Nephropathy Model by BOLD MRI: Comparison of Interventions. Oral presentation at Contrast Media Research (CMR) Symposiumat at Novotel Xinqiao Hotel in Beijing, China, on November 2 through 5, 2013.
  43. Lu-Ping Li, Jing Lu, Tammy Franklin, Jon Thacker, Maria Papadopulou, Richard Solomon, Ying Zhou, and Pottumarthi V. Prasad. Change in Intra-Renal Oxygenation by BOLD MRI as Early Marker of Iodinated Contrast Induced AKI (CIAKI). CRRT 2014, the 19th International Conference - Acute Kidney Injury: Controversies, Challenges and Solutions, Advances in Critical Care. March 4-7, 2014, San Diego, California, USA. Oral presentation and poster.
  44. Lu-Ping Li, Tammy Franklin, Richard Solomon, and Pottumarthi V. Prasad. Effect of Iodinated Contrast Medium in Diabetic Rat Kidney as Evaluated by BOLD MRI. Proc. Intl. Soc. Mag. Reson. Med. 22 (2014) 3558, Milan, Italy.
  45. Lu-Ping Li, Jon Thacker, Tammy Franklin, Jing Lu, Ying Zhou, Maria Papadopulou-Rosenzweig, Richard Solomon, and Pottumarthi V. Prasad. Changes in Intra-Renal Oxygenation by BOLD MRI as an Early Marker of Iodinated Contrast Induced Acute Kidney Injury. Proc. Intl. Soc. Mag. Reson. Med. 22 (2014) 3565, Milan, Italy.
  46. Jon Thacker, Huan Tan, Lu-Ping Li, Wei Li, Stuart Sprague, Orly Kohn, Ivana Lazich, and Pottumarthi V Prasad. ASL and BOLD MRI Measurements in Human Kidneys. Proc. Intl. Soc. Mag. Reson. Med. 22 (2014) 3569, Milan, Italy.
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