Antihistamines for Morning Sickness

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Topic Overview

Certain antihistamines such as dimenhydrinate or doxylamine, taken as your doctor advises, may relieve morning sickness.footnote 1 Doxylamine (Unisom SleepTabs) is available over-the-counter. If one of these antihistamines alone does not relieve your morning sickness, you can try taking it with vitamin B6.footnote 1 Talk to your doctor about the right dose.

Note: Do not confuse Unisom SleepTabs with Unisom SleepGels, which contain a different medicine.

A prescription medicine that combines doxylamine and vitamin B6 in one medicine (called Diclegis) is also available to treat morning sickness.

Common side effects of these medicines may include:

  • Drowsiness.
  • Dry mouth, nose, or throat.
  • Stomach upset.

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  1. Kelly TF, Savides TJ (2009). Gastrointestinal disease in pregnancy. In RK Creasy et al., eds., Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice, 6th ed., pp. 1041–1057. Philadelphia: Saunders Elsevier.


ByHealthwise Staff
Primary Medical ReviewerSarah Marshall, MD - Family Medicine
Specialist Medical ReviewerKirtly Jones, MD - Obstetrics and Gynecology

Current as ofMay 22, 2015