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It is not clear how zonisamide prevents
Zonisamide is used to treat partial seizures. It is used most often with other antiepileptic medicines.
When added to treatment with other antiepileptic medicines, zonisamide can reduce partial seizures in adults.1
Zonisamide may also help reduce absence seizures, myoclonic seizures, and infantile spasms.1
The most common side effects of zonisamide include:
In rare cases, zonisamide may cause a serious skin rash. Contact your doctor if you develop a rash while taking
FDA Advisory. The U.S. Food and Drug Administration (FDA) has
issued an advisory on antiepileptic drugs (AEDs) and the risk of suicide. Talk
to your doctor about these possible side effects and the warning signs of suicide in adults and in children and teens.
See Drug Reference for a full list of side effects. (Drug Reference
is not available in all systems.)
It may take time and careful, controlled adjustments by you and
your doctor to find the combination, schedule, and dosing of medicine to best
manage your epilepsy. The goal is to prevent seizures while causing as few
side effects as possible. After you and your doctor figure out the
medicine program that works best for you, make sure to follow your program
exactly as prescribed.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Drugs for epilepsy (2008). Treatment Guidelines From The Medical Letter, 6(70): 37–46.
August 28, 2013
John Pope, MD - Pediatrics
& Steven C. Schachter, MD - Neurology
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