« Previous Page

anakinra (injectable)

anakinra (injectable)

Pronunciation: an na KIN rah

Brand: Kineret

What is the most important information I should know about anakinra?

Multum donot

You should not use this medication if you are allergic to anakinra or to other medicines that contain E. coli bacteria proteins. You also should not use anakinra if you have an active infection.

Before using anakinra, tell your doctor if you have asthma, kidney disease, a latex allergy, a weak immune system, an active or chronic infection, or signs of infection such as fever, chills, or open sores on your skin.

Multum emt

Anakinra can lower blood cells that help your body fight infections. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Stop using this medicine and call your doctor right away if you have signs of infection such as: fever, chills, flu symptoms, mouth sores, weight loss, or feeling tired or short of breath.

You may have a higher risk of infection if you are also using adalimumab (Humira), certolizumab (Cimzia), etanercept (Enbrel), golimumab (Simponi), infliximab (Remicade), adalimumab (Humira), cancer medicines, steroids, or medicines to prevent organ transplant rejection.

Multum nochild

Do not give this medication to anyone under 18 years old without medical advice.

What is anakinra?

Anakinra reduces the actions of chemicals in the body that are involved in inflammatory and immune responses.

Anakinra is used to treat the symptoms of moderate to severe rheumatoid arthritis in adults. Anakinra may also help slow the progress of the disease.

Anakinra is usually given after other arthritis medications have been tried without successful treatment of symptoms.

Anakinra may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using anakinra?

Multum donot

You should not use this medication if you are allergic to anakinra or to other medicines that contain E. coli bacteria proteins. You also should not use anakinra if you have an active infection.

To make sure anakinra is safe for you, tell your doctor if you have:

  • an active or chronic infection;
  • a history of recurrent infections;
  • fever, chills, or open sores on your skin;
  • a weak immune system (caused by disease or by using certain medicines):
  • bone marrow suppression;
  • asthma;
  • kidney disease; or
  • if you are allergic to latex.

FDA pregnancy category B. Anakinra is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Multum nobrfeed

It is not known whether anakinra passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Multum nochild

Do not give this medication to anyone under 18 years old without medical advice.

How should I use anakinra?

Anakinra is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Anakinra is usually given once per day, or once every other day. Follow your doctor's instructions. Inject your dose at the same time of day when you use the medication.

Use a different place on your stomach, thigh, buttocks, or upper arm each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row. Each injection should be given at least 1 inch away from where you last injected the medicine.

Multum donot

Do not shake the prefilled syringe or you may ruin the medicine. Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed colors, looks cloudy, or has particles in it. Call your pharmacist for new medication.

Each prefilled syringe of anakinra is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Use anakinra regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Multum emt

Anakinra can lower blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. You will need regular medical tests to be sure this medication is not causing harmful effects. Your doctor may also want to check your blood cells for several months after you stop using anakinra. Visit your doctor regularly.

Multum emt

Call your doctor if your arthritis symptoms do not improve, or if they get worse while using anakinra.

Multum refig

Store in the refrigerator, do not freeze. Protect from light.

Throw away any unused medicine after the expiration date on the label has passed.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of anakinra.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while using anakinra?

Multum donot

Do not receive a "live" vaccine while using anakinra, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, yellow fever, varicella (chickenpox), zoster (shingles), oral typhoid vaccine, and nasal flu (influenza) vaccine.

Multum emt

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What are the possible side effects of anakinra?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Serious infections may occur during treatment with anakinra. Stop using this medicine and call your doctor right away if you have signs of infection such as:

  • fever, sweating, chills, tired feeling;
  • feeling short of breath;
  • cough, sore throat;
  • sores in your mouth and throat; or
  • flu symptoms, weight loss.

Less serious side effects may include:

  • nausea, diarrhea, stomach pain;
  • headache;
  • cold symptoms such as stuffy nose, sneezing, sore throat; or
  • redness, bruising, pain, or swelling where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect anakinra?

You may have a higher risk of infection from anakinra if you are also using:

  • certolizumab (Cimzia);
  • etanercept (Enbrel);
  • golimumab (Simponi);
  • infliximab (Remicade);
  • adalimumab (Humira); or
  • cancer medicines, steroids, or medicines to prevent organ transplant rejection.

This list is not complete and other drugs may interact with anakinra. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about anakinra.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 3.01. Revision date: 10/15/2012.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

× Alternate Text