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bicalutamide

bicalutamide

Pronunciation: bye ka LOO ta mide

Brand: Casodex

Bicalutamide 50 mg-APO

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Bicalutamide 50 mg-TEV

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What is the most important information I should know about bicalutamide?

Bicalutamide is used to treat prostate cancer.

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Bicalutamide should never be taken by a woman or a child.

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Although bicalutamide is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy.

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Bicalutamide can harm your liver. Call your doctor at once if you have nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

What is bicalutamide?

Bicalutamide is an anti-androgen. It works in the body by preventing the actions of androgens (male hormones).

Bicalutamide is used together with another hormone to treat prostate cancer.

Bicalutamide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking bicalutamide?

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You should not use this medication if you are allergic to bicalutamide.

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Bicalutamide should never be taken by a woman or a child.

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Although bicalutamide is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy.

To make sure bicalutamide is safe for you, tell your doctor if you have:

  • liver disease;
  • diabetes; or
  • any other serious illness.

How should I take bicalutamide?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

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Bicalutamide is given as part of a combination prostate cancer treatment with another medication called a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone, or LHRH. This medication prevents the testicles from producing testosterone.

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Treatment with bicalutamide and LHRH is usually started at the same time. Follow your doctor's instructions.

Bicalutamide is usually taken once per day in the morning or evening. You may take the medicine with or without food. Try to take the medication at the same time each day.

LHRH is given as an injection or a tiny implant injected through a needle under the skin around your navel. LHRH injections are given at intervals such as once every 4 weeks. Follow your doctor's instructions.

You should not stop using bicalutamide suddenly. Stopping suddenly may make your condition worse.

While using bicalutamide, you may need frequent blood tests at your doctor's office.

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Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Call your doctor for instructions if you miss an appointment for your LHRH injection.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking bicalutamide?

This medicine can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

What are the possible side effects of bicalutamide?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have:

  • chest pain, cough or trouble breathing;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • fever, chills, body aches, flu symptoms;
  • pale skin, easy bruising or bleeding;
  • blood in your urine; or
  • nausea, pain in your upper stomach, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • hot flashes;
  • breast pain or swelling;
  • weakness, dizziness;
  • back pain, pelvic pain, joint or muscle pain;
  • increased nighttime urination;
  • upset stomach, vomiting, diarrhea or constipation;
  • weight changes;
  • impotence, loss of interest in sex, or trouble having an orgasm;
  • dizziness, headache; or
  • sore throat, runny nose or other cold symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect bicalutamide?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with bicalutamide, especially:

  • buspirone;
  • sildenafil and other erectile dysfunction medicines;
  • warfarin, Coumadin;
  • an antibiotic--clarithromycin, erythromycin, telithromycin;
  • cholesterol medication--atorvastatin, lovastatin, simvastatin;
  • heart or blood pressure medication--amlodipine, diltiazem, dronedarone, eplerenone, felodipine, nifedipine, nisoldipine, quinidine, verapamil
  • HIV medication--darunavir, indinavir, lopinavir, maraviroc, saquinavir, tipranavir;
  • medicine to prevent organ transplant rejection--cyclosporine, everolimus, sirolimus, tacrolimus;
  • medicine to treat mental illness--aripiprazole, lurasidone, quetiapine;
  • a sedative--alprazolam, diazepam, midazolam, triazolam; or
  • a steroid--budesonide, fluticasone.

This list is not complete. Other drugs may interact with bicalutamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about bicalutamide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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