Inherited Blood-Clotting Problems

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Topic Overview

Some people are born with an increased tendency to form blood clots. This makes them more likely to get blood clots in the legs (deep vein thrombosis) and in the lungs (pulmonary embolism). This tendency is due to inherited blood-clotting problems, which are often related to:

  • Mutated genes (such as factor V Leiden, factor II).
  • Decreased amounts of certain proteins. These may include protein C, protein S, and antithrombin III.
  • Increased levels of other substances. These may include antiphospholipid and lupus anticoagulant.

Many of these blood-clotting irregularities can be found with special tests. If your doctor suspects that you may have an inherited blood-clotting problem, discuss whether you need testing.

Related Information

References

Other Works Consulted

  • Lipe B, Ornstein DL (2011). Deficiencies of natural anticoagulants, protein C, protein S, and antithrombin. Circulation, 124(14): e365–e368.

Credits

ByHealthwise Staff
Primary Medical ReviewerE. Gregory Thompson, MD - Internal Medicine
Specialist Medical ReviewerJeffrey S. Ginsberg, MD - Hematology

Current as ofSeptember 9, 2014