Vitamin D Intervention Study In African Americans With A History Of Colon Cancer Or Colonic Adenomas (IRB 12-2172-AM003)
Aims:
Colon cancer is a leading cause of cancer-related mortality in the US.  African Americans (AA) suffer disproportionately from colon cancer. Possible causes for this discrepancy include social, cultural, and environmental factors, and differences in tumor biology and susceptibility alleles. This study proposes to measure the effects of a dietary vitamin D intervention on intermediate biomarkers in African Americans with a history of colon cancer or colonic adenomas.
Diagnosis:
Colon Cancer or Colonic Adenomas
Principal Investigator:
Michael J. Goldberg, MD
Other Investigator:
Laura Bianchi, MD
IRB Approval Number:
EH 13-195
Sponsor:
University of Chicago
Contact:
Interested patients should contact study coordinator, Boris Jancan, CCRP at 847.570.1583
Open to Enrollment:
Yes

Polyethylene Glycol for ACF Reduction and Biomarker Modulation in Individuals with Colorectal Cancer Risk (NWU 06-8-01)
Aims:
The purpose of this study is to determine whether the study medication, PEG (polyethylene glycol), can modify the risk of developing colon polyps or cancer. We will evaluate the levels of the molecules that are important in colon polyp formation and study the impact of PEG on these molecules. The study medication, PEG, is widely used as a laxative medication for people who have constipation and is available over-the-counter (without prescription). In pre-clinical (animal) models, PEG has been noted to decrease development of colon tumors. This study is designed to whether treatment with PEG will decrease the risk of colon cancer. The study medication, PEG, has not yet received approval from the Food and Drug Administration (FDA) for reducing abnormalities in the colon or the risk of colon cancer.
Diagnosis:
Colonic Adenomas
Principal Investigator:
Laura Bianchi, MD
Other Investigator:
Michael J. Goldberg, MD
IRB Approval Number:
EH 08-227
Sponsor:
National Cancer Institute
Contact:
Interested patients should contact study coordinator, Boris Jancan, CCRP at 847.570.1583
Open to Enrollment:
Yes

Spectroscopy of Blood Supply Changes in Early Precancer
Aims:
The purpose of this study is to investigate whether Light-Scattering Spectroscopy (LSS) analysis of normal colon tissue will enable us to determine the presence of colon polyps or cancers. To participate, the physician performing your colonoscopy will take six small biopsies from your colon and analyze them with LSS. LSS is a novel technology in which light is shined on tissue samples and the reflected light is analyzed. The analysis can provide information regarding the molecular composition of the cells. We have used this technology to analyze animal tissue, and we have found that in this experimental model we are able to detect which animals may develop colon cancer.
Diagnosis:
Colon Cancer, Colonic Adenomas, and Healthy Subjects
Principal Investigator:
Roy K. Hemant, MD
Other Investigators:
Michael J. Goldberg, MD and Laura Bianchi, MD
IRB Approval Number:
EH 03-306
Sponsor:
National Institute of Health
Contact:
Interested patients should contact study coordinator, Boris Jancan, CCRP at 847.570.1583
Open to Enrollment:
Yes

Spectral Markers for Early Detection of Colon Neoplasia - Renewal (CA11257)
Aims:
The purpose of this study is to help investigators develop a new method for the early detection of colon cancer. To prevent deaths from colon cancer, current efforts are focused on early detection largely through colonoscopy. However, this approach is expensive and has a number of associated complications, leading to a desire for other methods of early detection. Partial Wave Spectroscopy (PWS) is a method of examining tissue. PWS technology involves shining light on a tissue sample. When the light encounters the tissue, the structure of the internal cells causes the light to scatter in different ways. Information about the tissue can be gathered from the way that the light is scattered. This study will look for changes in tissue samples from the inside of the rectum (the last part of the large bowel). The approach is based on the theory that patients who are at risk for colon cancer have colon cells that are subtly abnormal. We believe PWS may allow us to identify these cells. We hope to identify cellular changes which may someday be useful in identifying subjects at risk of colon cancer.
Diagnosis:
Colon Cancer, Colonic Adenomas, and Healthy Subjects
Principal Investigator:
Roy K. Hemant, MD
Other Investigators:
Michael J. Goldberg, MD and Laura Bianchi, MD
IRB Approval Number: EH 09-524
Sponsor:
National Institute of Health
Contact:
Interested patients should contact study coordinator, Boris Jancan, CCRP at 847.570.1583
Open to Enrollment:
Yes

Optical Nanoscale Analysis of Buccal Cells: Transforming Lung Cancer Screening
Aims: The purpose of this study is to develop a new method for the early detection of lung cancer. This will be done by collecting samples with a brush from the cheek area inside the mouth (buccal mucosa), then testing these samples with Partial Wave Spectroscopy (PWS). PWS technology involves shining light on a tissue sample. When the light encounters the tissue, the structure of the internal cells causes the light to scatter in different ways. Information about the tissue can be gathered from the way that the light is scattered. The purpose of this test is to look for changes in the buccal mucosa. We hope to identify cell changes in the samples which may be useful in the early detection of lung cancer.
Diagnosis: Lung Cancer, Lung Solitary Nodule, Smokers, Esophageal, Pancreatic or Head and Neck Cancer, Breast Cancer, or Colon Cancer, Chronic Obstructive Pulmonary Disease (COPD) or Pulmonary Fibrosis
Principal Investigator: Roy K. Hemant, MD
Other Investigators: Michael J. Goldberg, MD and Laura Bianchi, MD
IRB Approval Number: EH 10-137
Sponsor: National Institute of Health
Contact: Interested patients should contact Boris Jancan, CCRP at 847.570.1583
Open to Enrollment: Yes

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